ID A0A4V0IJ47_CAEEL Unreviewed; 834 AA. AC A0A4V0IJ47; DT 31-JUL-2019, integrated into UniProtKB/TrEMBL. DT 31-JUL-2019, sequence version 1. DT 29-MAY-2024, entry version 20. DE SubName: Full=Degenerin deg-1 {ECO:0000313|EMBL:VTW47533.1}; GN Name=deg-1 {ECO:0000313|EMBL:VTW47533.1, GN ECO:0000313|WormBase:C47C12.6e}; GN ORFNames=C47C12.6 {ECO:0000313|WormBase:C47C12.6e}, CELE_C47C12.6 GN {ECO:0000313|EMBL:VTW47533.1}; OS Caenorhabditis elegans. OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; OC Caenorhabditis. OX NCBI_TaxID=6239 {ECO:0000313|EMBL:VTW47533.1, ECO:0000313|Proteomes:UP000001940}; RN [1] {ECO:0000313|EMBL:VTW47533.1, ECO:0000313|Proteomes:UP000001940} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Bristol N2 {ECO:0000313|EMBL:VTW47533.1, RC ECO:0000313|Proteomes:UP000001940}; RX PubMed=9851916; DOI=10.1126/science.282.5396.2012; RG The C. elegans sequencing consortium; RA Sulson J.E., Waterston R.; RT "Genome sequence of the nematode C. elegans: a platform for investigating RT biology."; RL Science 282:2012-2018(1998). CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi- CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. CC -!- SIMILARITY: Belongs to the amiloride-sensitive sodium channel (TC CC 1.A.6) family. {ECO:0000256|ARBA:ARBA00007193, CC ECO:0000256|RuleBase:RU000679}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; BX284606; VTW47533.1; -; Genomic_DNA. DR AlphaFoldDB; A0A4V0IJ47; -. DR SMR; A0A4V0IJ47; -. DR EnsemblMetazoa; C47C12.6e.1; C47C12.6e.1; WBGene00000950. DR AGR; WB:WBGene00000950; -. DR WormBase; C47C12.6e; CE53486; WBGene00000950; deg-1. DR OrthoDB; 3075301at2759; -. DR Proteomes; UP000001940; Chromosome X. DR ExpressionAtlas; A0A4V0IJ47; baseline and differential. DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell. DR GO; GO:0015280; F:ligand-gated sodium channel activity; IEA:TreeGrafter. DR Gene3D; 2.60.470.10; Acid-sensing ion channels like domains; 1. DR Gene3D; 1.10.287.770; YojJ-like; 1. DR InterPro; IPR004726; Deg-1. DR InterPro; IPR001873; ENaC. DR InterPro; IPR020903; ENaC_CS. DR NCBIfam; TIGR00867; deg-1; 1. DR PANTHER; PTHR11690; AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED; 1. DR PANTHER; PTHR11690:SF276; DEGENERIN DEG-1; 1. DR Pfam; PF00858; ASC; 1. DR PRINTS; PR01078; AMINACHANNEL. DR PROSITE; PS01206; ASC; 1. PE 1: Evidence at protein level; KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180}; KW Ion channel {ECO:0000256|RuleBase:RU000679}; KW Ion transport {ECO:0000256|RuleBase:RU000679}; KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius}; KW Proteomics identification {ECO:0007829|EPD:A0A4V0IJ47}; KW Reference proteome {ECO:0000313|Proteomes:UP000001940}; KW Sodium {ECO:0000256|ARBA:ARBA00023053}; KW Sodium channel {ECO:0000256|ARBA:ARBA00022461, KW ECO:0000256|RuleBase:RU000679}; KW Sodium transport {ECO:0000256|ARBA:ARBA00023201, KW ECO:0000256|RuleBase:RU000679}; KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, KW ECO:0000256|RuleBase:RU000679}; KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|RuleBase:RU000679}. FT TRANSMEM 78..96 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 769..795 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT REGION 154..180 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 201..220 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 344..437 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 154..174 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 834 AA; 93964 MW; BDB1FA9D951076D3 CRC64; MSNHHSKTKK TSMLGREDYI YSHDITNKNK KEKLNGASKN NDYNQDDDDE TMKSKMMDFC DKTTAHGAKR VLIARNSFSK LMWGLIIFSF LLMFAYQASK LIFKFSAHEK ITDISLKFDD VEFPAITFCN LNPYKKSLVM MVPSIRDTMD VYDNAKTHSK SEGEKKKPKV SRKQHSDASQ QMVRELFAKE IEEGMVELKK SNKTLQSQNK SGRRRSQRSI ENRRYEAIEA HCKCVGNIGM ECIRFESPPR DPSSKCICTY DRDMEVAWPC FNISVWYDHE CPLCHDDGYC ESTLPSGTTS SDKWPCMCRN RGDTSERDDT PYCIGKAGVG KIEIRKLWLE NNMTTTSTTT TTTTTPPPTT TSTTTTTTTT PPPTTTVSTS TSTTSTTTTT TTTTTPRPTT TEKTTTTPRP TTSTTSTTTT THPPTTTTTP YPTRPNQRAI VSNPETIKAM GFQGMTDGVA MLTRAKENLM FTMAALSDKQ RIALSQSKHE FIEMCSFNGK ECDIDEDFRL HVDPEFGNCF TFNYDVNNNY TSSRAGPMYG IRVLLFVNTS DYMSTSESSG VRLAIHPPTE YPFPDTFGYS APVGFASSFG IKKKVMQRLP APYGECVETK KVVDRNYIYA GYDYHPEGCH RSCFQNGLID DCSCGDPRFP VPEGYRHCSA FNATARTCLE KNIGSVGDFH HITQKMDKCV CKQSCEEIIH EVTFSCSKWP SGATDLGDCD GMTESECEQY YRLNAAMIEV FYEQLNYELL QESEAYGLVN LIADFGGHLG LWLGFSVITV MEVCVLLVDM ISLFFKSRHE EKLLRQSTKR KDVPEDKRQI TVGSGRKSDA FVSI //