ID A0A4U1ETG1_MONMO Unreviewed; 158 AA. AC A0A4U1ETG1; DT 31-JUL-2019, integrated into UniProtKB/TrEMBL. DT 31-JUL-2019, sequence version 1. DT 07-OCT-2020, entry version 7. DE RecName: Full=RNA-binding protein 8A {ECO:0000256|RuleBase:RU361239}; GN ORFNames=EI555_021055 {ECO:0000313|EMBL:TKC39975.1}; OS Monodon monoceros (Narwhal) (Ceratodon monodon). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti; OC Monodontidae; Monodon. OX NCBI_TaxID=40151 {ECO:0000313|EMBL:TKC39975.1, ECO:0000313|Proteomes:UP000308365}; RN [1] {ECO:0000313|Proteomes:UP000308365} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=31054839; DOI=10.1016/j.isci.2019.03.023; RA Westbury M.V., Petersen B., Garde E., Heide-Jorgensen M.P., Lorenzen E.D.; RT "Narwhal Genome Reveals Long-Term Low Genetic Diversity despite Current RT Large Abundance Size."; RL IScience 15:592-599(2019). CC -!- FUNCTION: Core component of the splicing-dependent multiprotein exon CC junction complex (EJC) deposited at splice junctions on mRNAs. CC {ECO:0000256|RuleBase:RU361239}. CC -!- SUBUNIT: Heterodimer with MAGOH. Part of the mRNA splicing-dependent CC exon junction complex (EJC) complex; the core complex contains CASC3, CC EIF4A3, MAGOH and RBM8A. {ECO:0000256|RuleBase:RU361239}. CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496, CC ECO:0000256|RuleBase:RU361239}. Nucleus speckle CC {ECO:0000256|ARBA:ARBA00004324, ECO:0000256|RuleBase:RU361239}. Nucleus CC {ECO:0000256|RuleBase:RU361239}. CC -!- SIMILARITY: Belongs to the RBM8A family. CC {ECO:0000256|ARBA:ARBA00007987, ECO:0000256|RuleBase:RU361239}. CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ CC whole genome shotgun (WGS) entry which is preliminary data. CC {ECO:0000313|EMBL:TKC39975.1}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; RWIC01000816; TKC39975.1; -; Genomic_DNA. DR Proteomes; UP000308365; Unassembled WGS sequence. DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. DR GO; GO:0016607; C:nuclear speck; IEA:UniProtKB-SubCell. DR GO; GO:0005681; C:spliceosomal complex; IEA:UniProtKB-KW. DR GO; GO:0003729; F:mRNA binding; IEA:InterPro. DR GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW. DR GO; GO:0051028; P:mRNA transport; IEA:UniProtKB-KW. DR GO; GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; IEA:UniProtKB-KW. DR GO; GO:0008380; P:RNA splicing; IEA:UniProtKB-KW. DR CDD; cd12324; RRM_RBM8; 1. DR Gene3D; 3.30.70.330; -; 1. DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf. DR InterPro; IPR035979; RBD_domain_sf. DR InterPro; IPR008111; RNA-bd_8. DR InterPro; IPR000504; RRM_dom. DR InterPro; IPR033744; RRM_RBM8. DR Pfam; PF00076; RRM_1; 1. DR PRINTS; PR01738; RNABINDINGM8. DR SMART; SM00360; RRM; 1. DR SUPFAM; SSF54928; SSF54928; 1. DR PROSITE; PS50102; RRM; 1. PE 3: Inferred from homology; KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|RuleBase:RU361239}; KW mRNA processing {ECO:0000256|ARBA:ARBA00022664, KW ECO:0000256|RuleBase:RU361239}; KW mRNA splicing {ECO:0000256|ARBA:ARBA00023187, KW ECO:0000256|RuleBase:RU361239}; KW mRNA transport {ECO:0000256|RuleBase:RU361239}; KW Nonsense-mediated mRNA decay {ECO:0000256|ARBA:ARBA00023161}; KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU361239}; KW Reference proteome {ECO:0000313|Proteomes:UP000308365}; KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|PROSITE- KW ProRule:PRU00176, ECO:0000256|RuleBase:RU361239}; KW Spliceosome {ECO:0000256|ARBA:ARBA00022728}; KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU361239}. FT DOMAIN 57..135 FT /note="RRM" FT /evidence="ECO:0000259|PROSITE:PS50102" FT REGION 1..54 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 135..158 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 20..49 FT /note="Polyampholyte" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 140..158 FT /note="Basic" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 158 AA; 18217 MW; 392A814BF0747CA1 CRC64; MDEDGDESIH KLKEKAKKRK GRGFGSEEGS RARMREDYDS VEQDGDEPGP QRSVEGWILF VTGVHEEATE EDIHDKFAEY GEIKNIHLNL DRRTGYLKGY TLVEYETYKE AQAAMEGLNG QDLMGQPISV DWCFVRGPPK GKRRGGRRRS RSPDRRRR //