ID A0A4U1ETG1_MONMO Unreviewed; 158 AA. AC A0A4U1ETG1; DT 31-JUL-2019, integrated into UniProtKB/TrEMBL. DT 31-JUL-2019, sequence version 1. DT 16-OCT-2019, entry version 3. DE RecName: Full=RNA-binding protein 8A {ECO:0000256|RuleBase:RU361239}; GN ORFNames=EI555_021055 {ECO:0000313|EMBL:TKC39975.1}; OS Monodon monoceros (Narwhal) (Ceratodon monodon). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Cetacea; OC Odontoceti; Monodontidae; Monodon. OX NCBI_TaxID=40151 {ECO:0000313|EMBL:TKC39975.1}; RN [1] {ECO:0000313|EMBL:TKC39975.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=MVW {ECO:0000313|EMBL:TKC39975.1}; RC TISSUE=Liver {ECO:0000313|EMBL:TKC39975.1}; RA Westbury M.V., Petersen B., Garde E., Heide-Jorgensen M.P., RA Lorenzen E.D.; RT "Narwhal Genome Reveals Long-Term Low Genetic Diversity despite RT Current Large Abundance Size."; RL IScience 0:0-0(2019). CC -!- FUNCTION: Core component of the splicing-dependent multiprotein CC exon junction complex (EJC) deposited at splice junctions on CC mRNAs. {ECO:0000256|RuleBase:RU361239}. CC -!- SUBUNIT: Heterodimer with MAGOH. Part of the mRNA splicing- CC dependent exon junction complex (EJC) complex; the core complex CC contains CASC3, EIF4A3, MAGOH and RBM8A. CC {ECO:0000256|RuleBase:RU361239}. CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU361239}. CC Nucleus speckle {ECO:0000256|RuleBase:RU361239}. Cytoplasm CC {ECO:0000256|RuleBase:RU361239}. CC -!- SIMILARITY: Belongs to the RBM8A family. CC {ECO:0000256|RuleBase:RU361239}. CC -!- CAUTION: The sequence shown here is derived from an CC EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is CC preliminary data. {ECO:0000313|EMBL:TKC39975.1}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; RWIC01000816; TKC39975.1; -; Genomic_DNA. DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. DR GO; GO:0016607; C:nuclear speck; IEA:UniProtKB-SubCell. DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule. DR GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW. DR GO; GO:0051028; P:mRNA transport; IEA:UniProtKB-KW. DR GO; GO:0008380; P:RNA splicing; IEA:UniProtKB-KW. DR CDD; cd12324; RRM_RBM8; 1. DR Gene3D; 3.30.70.330; -; 1. DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf. DR InterPro; IPR035979; RBD_domain_sf. DR InterPro; IPR008111; RNA-bd_8. DR InterPro; IPR000504; RRM_dom. DR InterPro; IPR033744; RRM_RBM8. DR Pfam; PF00076; RRM_1; 1. DR PRINTS; PR01738; RNABINDINGM8. DR SMART; SM00360; RRM; 1. DR SUPFAM; SSF54928; SSF54928; 1. DR PROSITE; PS50102; RRM; 1. PE 3: Inferred from homology; KW Cytoplasm {ECO:0000256|RuleBase:RU361239}; KW mRNA processing {ECO:0000256|RuleBase:RU361239}; KW mRNA splicing {ECO:0000256|RuleBase:RU361239}; KW mRNA transport {ECO:0000256|RuleBase:RU361239}; KW Nucleus {ECO:0000256|RuleBase:RU361239}; KW RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00176, KW ECO:0000256|RuleBase:RU361239}; KW Transport {ECO:0000256|RuleBase:RU361239}. FT DOMAIN 57 135 RRM. {ECO:0000259|PROSITE:PS50102}. FT REGION 1 54 Disordered. {ECO:0000256|SAM:MobiDB- FT lite}. FT REGION 135 158 Disordered. {ECO:0000256|SAM:MobiDB- FT lite}. FT COMPBIAS 20 49 Polyampholyte. {ECO:0000256|SAM:MobiDB- FT lite}. FT COMPBIAS 140 158 Basic. {ECO:0000256|SAM:MobiDB-lite}. SQ SEQUENCE 158 AA; 18217 MW; 392A814BF0747CA1 CRC64; MDEDGDESIH KLKEKAKKRK GRGFGSEEGS RARMREDYDS VEQDGDEPGP QRSVEGWILF VTGVHEEATE EDIHDKFAEY GEIKNIHLNL DRRTGYLKGY TLVEYETYKE AQAAMEGLNG QDLMGQPISV DWCFVRGPPK GKRRGGRRRS RSPDRRRR //