ID   A0A4U0YGU5_9PSED        Unreviewed;       280 AA.
AC   A0A4U0YGU5;
DT   31-JUL-2019, integrated into UniProtKB/TrEMBL.
DT   31-JUL-2019, sequence version 1.
DT   16-OCT-2019, entry version 3.
DE   RecName: Full=NADH pyrophosphatase {ECO:0000256|HAMAP-Rule:MF_00297, ECO:0000256|SAAS:SAAS00345522};
DE            EC=3.6.1.22 {ECO:0000256|HAMAP-Rule:MF_00297};
GN   Name=nudC {ECO:0000256|HAMAP-Rule:MF_00297,
GN   ECO:0000313|EMBL:TKA90308.1};
GN   ORFNames=FA869_14390 {ECO:0000313|EMBL:TKA90308.1};
OS   Pseudomonas bauzanensis.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=653930 {ECO:0000313|EMBL:TKA90308.1};
RN   [1] {ECO:0000313|EMBL:TKA90308.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=SBBB {ECO:0000313|EMBL:TKA90308.1};
RA   Bhattacharya S., Roy C., Mondal N., Sarkar J., Mandal S., Rameez M.J.,
RA   Ghosh W.;
RT   "Crypto-aerobic microbial life in anoxic (sulfidic) marine
RT   sediments.";
RL   Submitted (APR-2019) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H2O + NAD(+) = AMP + beta-nicotinamide D-ribonucleotide +
CC         2 H(+); Xref=Rhea:RHEA:11800, ChEBI:CHEBI:14649,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540,
CC         ChEBI:CHEBI:456215; EC=3.6.1.22; Evidence={ECO:0000256|HAMAP-
CC         Rule:MF_00297, ECO:0000256|SAAS:SAAS01118353};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H2O + NADH = AMP + 2 H(+) + reduced beta-nicotinamide D-
CC         ribonucleotide; Xref=Rhea:RHEA:48868, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:57945, ChEBI:CHEBI:90832,
CC         ChEBI:CHEBI:456215; EC=3.6.1.22; Evidence={ECO:0000256|HAMAP-
CC         Rule:MF_00297, ECO:0000256|SAAS:SAAS01118352};
CC   -!- COFACTOR:
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000256|SAAS:SAAS00608010};
CC   -!- SUBUNIT: Homodimer. {ECO:0000256|HAMAP-Rule:MF_00297,
CC       ECO:0000256|SAAS:SAAS00042551}.
CC   -!- SIMILARITY: Belongs to the Nudix hydrolase family. NudC subfamily.
CC       {ECO:0000256|HAMAP-Rule:MF_00297, ECO:0000256|SAAS:SAAS00541212}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:TKA90308.1}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; SWAV01000005; TKA90308.1; -; Genomic_DNA.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030145; F:manganese ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0000210; F:NAD+ diphosphatase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_00297; Nudix_NudC; 1.
DR   InterPro; IPR015375; NADH_PPase-like_N.
DR   InterPro; IPR022925; NADH_pyroPase_NudC.
DR   InterPro; IPR020476; Nudix_hydrolase.
DR   InterPro; IPR015797; NUDIX_hydrolase-like_dom_sf.
DR   InterPro; IPR020084; NUDIX_hydrolase_CS.
DR   InterPro; IPR000086; NUDIX_hydrolase_dom.
DR   InterPro; IPR015376; Znr_NADH_PPase.
DR   Pfam; PF00293; NUDIX; 1.
DR   Pfam; PF09296; NUDIX-like; 1.
DR   Pfam; PF09297; zf-NADH-PPase; 1.
DR   PRINTS; PR00502; NUDIXFAMILY.
DR   SUPFAM; SSF55811; SSF55811; 2.
DR   PROSITE; PS51462; NUDIX; 1.
DR   PROSITE; PS00893; NUDIX_BOX; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|HAMAP-Rule:MF_00297,
KW   ECO:0000256|RuleBase:RU003476, ECO:0000256|SAAS:SAAS00025287,
KW   ECO:0000313|EMBL:TKA90308.1};
KW   Magnesium {ECO:0000256|HAMAP-Rule:MF_00297,
KW   ECO:0000256|SAAS:SAAS00016165};
KW   Manganese {ECO:0000256|HAMAP-Rule:MF_00297,
KW   ECO:0000256|SAAS:SAAS00016184};
KW   Metal-binding {ECO:0000256|HAMAP-Rule:MF_00297,
KW   ECO:0000256|SAAS:SAAS00016198};
KW   NAD {ECO:0000256|HAMAP-Rule:MF_00297, ECO:0000256|SAAS:SAAS00016191};
KW   Zinc {ECO:0000256|HAMAP-Rule:MF_00297, ECO:0000256|SAAS:SAAS01085471}.
FT   DOMAIN      143    267       Nudix hydrolase. {ECO:0000259|PROSITE:
FT                                PS51462}.
FT   MOTIF       177    198       Nudix box. {ECO:0000256|HAMAP-Rule:
FT                                MF_00297}.
FT   METAL       116    116       Zinc. {ECO:0000256|HAMAP-Rule:MF_00297}.
FT   METAL       119    119       Zinc. {ECO:0000256|HAMAP-Rule:MF_00297}.
FT   METAL       134    134       Zinc. {ECO:0000256|HAMAP-Rule:MF_00297}.
FT   METAL       137    137       Zinc. {ECO:0000256|HAMAP-Rule:MF_00297}.
FT   METAL       192    192       Divalent metal cation.
FT                                {ECO:0000256|HAMAP-Rule:MF_00297}.
FT   METAL       196    196       Divalent metal cation.
FT                                {ECO:0000256|HAMAP-Rule:MF_00297}.
SQ   SEQUENCE   280 AA;  31561 MW;  481D012864C31D31 CRC64;
     MIPVQRFTRF TASLTTETHA DGWVLIRHEQ SFAMYQGNLL HDPDMARYLG DAEYQMTLGL
     VDDRPCQLVR VKEQIDLPGL SWHGLRSLLG QVDDSTFRLL GVAQQLDIWH DTHRFCGRCG
     QPTQVRPDER AMECSGCGNR QYPKLAPCII VLITRGEEVL LARSANFRAG FFSTLAGFIE
     PGESAEEALR REVMEEVGVT VDHIEYLGSQ NWPFPNSLML GFHASYVDGE IVPQPGEIEE
     AHWWNIHQLP AIPPQGTISR WLIDCYLARL AGQPQPPVPA
//