ID A0A4T1ZUW9_9PSED Unreviewed; 275 AA. AC A0A4T1ZUW9; DT 31-JUL-2019, integrated into UniProtKB/TrEMBL. DT 31-JUL-2019, sequence version 1. DT 16-OCT-2019, entry version 3. DE RecName: Full=NADH pyrophosphatase {ECO:0000256|HAMAP-Rule:MF_00297, ECO:0000256|SAAS:SAAS00345522}; DE EC=3.6.1.22 {ECO:0000256|HAMAP-Rule:MF_00297}; GN Name=nudC {ECO:0000256|HAMAP-Rule:MF_00297}; GN ORFNames=D8779_11205 {ECO:0000313|EMBL:TIH08085.1}; OS Pseudomonas sp. CCM 8849. OC Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales; OC Pseudomonadaceae; Pseudomonas. OX NCBI_TaxID=2448482 {ECO:0000313|EMBL:TIH08085.1}; RN [1] {ECO:0000313|EMBL:TIH08085.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=CCM 8849 {ECO:0000313|EMBL:TIH08085.1}; RA Novakova D., Svec P., Kralova S., Kristofova L., Zeman M., RA Pantucek R., Maslanova I., Sedlacek I.; RT "Pseudomonas leptonychotis sp. nov., isolated from Weddell seals in RT Antarctica."; RL Submitted (OCT-2018) to the EMBL/GenBank/DDBJ databases. CC -!- CATALYTIC ACTIVITY: CC Reaction=H2O + NAD(+) = AMP + beta-nicotinamide D-ribonucleotide + CC 2 H(+); Xref=Rhea:RHEA:11800, ChEBI:CHEBI:14649, CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540, CC ChEBI:CHEBI:456215; EC=3.6.1.22; Evidence={ECO:0000256|HAMAP- CC Rule:MF_00297, ECO:0000256|SAAS:SAAS01118353}; CC -!- CATALYTIC ACTIVITY: CC Reaction=H2O + NADH = AMP + 2 H(+) + reduced beta-nicotinamide D- CC ribonucleotide; Xref=Rhea:RHEA:48868, ChEBI:CHEBI:15377, CC ChEBI:CHEBI:15378, ChEBI:CHEBI:57945, ChEBI:CHEBI:90832, CC ChEBI:CHEBI:456215; EC=3.6.1.22; Evidence={ECO:0000256|HAMAP- CC Rule:MF_00297, ECO:0000256|SAAS:SAAS01118352}; CC -!- COFACTOR: CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035; CC Evidence={ECO:0000256|SAAS:SAAS00608010}; CC -!- SUBUNIT: Homodimer. {ECO:0000256|HAMAP-Rule:MF_00297, CC ECO:0000256|SAAS:SAAS00042551}. CC -!- SIMILARITY: Belongs to the Nudix hydrolase family. NudC subfamily. CC {ECO:0000256|HAMAP-Rule:MF_00297, ECO:0000256|SAAS:SAAS00541212}. CC -!- CAUTION: The sequence shown here is derived from an CC EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is CC preliminary data. {ECO:0000313|EMBL:TIH08085.1}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; RFLV01000002; TIH08085.1; -; Genomic_DNA. DR GO; GO:0000287; F:magnesium ion binding; IEA:UniProtKB-UniRule. DR GO; GO:0030145; F:manganese ion binding; IEA:UniProtKB-UniRule. DR GO; GO:0000210; F:NAD+ diphosphatase activity; IEA:UniProtKB-UniRule. DR GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule. DR HAMAP; MF_00297; Nudix_NudC; 1. DR InterPro; IPR015375; NADH_PPase-like_N. DR InterPro; IPR022925; NADH_pyroPase_NudC. DR InterPro; IPR015797; NUDIX_hydrolase-like_dom_sf. DR InterPro; IPR020084; NUDIX_hydrolase_CS. DR InterPro; IPR000086; NUDIX_hydrolase_dom. DR InterPro; IPR015376; Znr_NADH_PPase. DR Pfam; PF00293; NUDIX; 1. DR Pfam; PF09296; NUDIX-like; 1. DR Pfam; PF09297; zf-NADH-PPase; 1. DR SUPFAM; SSF55811; SSF55811; 2. DR PROSITE; PS51462; NUDIX; 1. DR PROSITE; PS00893; NUDIX_BOX; 1. PE 3: Inferred from homology; KW Hydrolase {ECO:0000256|HAMAP-Rule:MF_00297, KW ECO:0000256|SAAS:SAAS00437314, ECO:0000313|EMBL:TIH08085.1}; KW Magnesium {ECO:0000256|HAMAP-Rule:MF_00297, KW ECO:0000256|SAAS:SAAS00016165}; KW Manganese {ECO:0000256|HAMAP-Rule:MF_00297, KW ECO:0000256|SAAS:SAAS00016184}; KW Metal-binding {ECO:0000256|HAMAP-Rule:MF_00297, KW ECO:0000256|SAAS:SAAS00016198}; KW NAD {ECO:0000256|HAMAP-Rule:MF_00297, ECO:0000256|SAAS:SAAS00016191}; KW Zinc {ECO:0000256|HAMAP-Rule:MF_00297, ECO:0000256|SAAS:SAAS01085471}. FT DOMAIN 138 261 Nudix hydrolase. {ECO:0000259|PROSITE: FT PS51462}. FT MOTIF 172 193 Nudix box. {ECO:0000256|HAMAP-Rule: FT MF_00297}. FT METAL 111 111 Zinc. {ECO:0000256|HAMAP-Rule:MF_00297}. FT METAL 114 114 Zinc. {ECO:0000256|HAMAP-Rule:MF_00297}. FT METAL 129 129 Zinc. {ECO:0000256|HAMAP-Rule:MF_00297}. FT METAL 132 132 Zinc. {ECO:0000256|HAMAP-Rule:MF_00297}. FT METAL 187 187 Divalent metal cation. FT {ECO:0000256|HAMAP-Rule:MF_00297}. FT METAL 191 191 Divalent metal cation. FT {ECO:0000256|HAMAP-Rule:MF_00297}. SQ SEQUENCE 275 AA; 31015 MW; 5051099A42DB561B CRC64; MQRWQPTLLD SQLPGGWVVA HFKQHFLADS NGVLFPREWL KQQDLPIVAE HGLGHFDGDA IYLLELSQPF DMQGCAWQSL RQFMLQGDAD TFKLLSYATQ IGTWASQHRF CGSCGETMQH IPGERAMHCV RCELQHYPRL SPSMIVLVTR GDEVLLARSP RFVSGVYSTL AGFVEAGESV EHCVAREVRE EVGVEIKNLQ YLGSQGWPFP HSLMLGFHAE YDSGDIVMQA DEIEDAQWFN VHDLPPLPAT RSIARHLIDV YVARRLGHPE PVLPG //