ID A0A4R5N4G5_9LACO Unreviewed; 243 AA. AC A0A4R5N4G5; DT 31-JUL-2019, integrated into UniProtKB/TrEMBL. DT 31-JUL-2019, sequence version 1. DT 14-DEC-2022, entry version 8. DE RecName: Full=Isoprenyl transferase {ECO:0000256|HAMAP-Rule:MF_01139}; DE EC=2.5.1.- {ECO:0000256|HAMAP-Rule:MF_01139}; GN ORFNames=C5L19_001106 {ECO:0000313|EMBL:TDG64357.1}; OS Lactobacillus delbrueckii subsp. jakobsenii. OC Bacteria; Firmicutes; Bacilli; Lactobacillales; Lactobacillaceae; OC Lactobacillus. OX NCBI_TaxID=1537158 {ECO:0000313|EMBL:TDG64357.1, ECO:0000313|Proteomes:UP000295697}; RN [1] {ECO:0000313|EMBL:TDG64357.1, ECO:0000313|Proteomes:UP000295697} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=DSM 26046 {ECO:0000313|EMBL:TDG64357.1, RC ECO:0000313|Proteomes:UP000295697}; RX PubMed=30830251; DOI=.1007/s00253-019-09701-6; RA Buron-Moles G., Chailyan A., Dolejs I., Forster J., Miks M.H.; RT "Uncovering carbohydrate metabolism through a genotype-phenotype RT association study of 56 lactic acid bacteria genomes."; RL Appl. Microbiol. Biotechnol. 103:3135-3152(2019). CC -!- FUNCTION: Catalyzes the condensation of isopentenyl diphosphate (IPP) CC with allylic pyrophosphates generating different type of terpenoids. CC {ECO:0000256|HAMAP-Rule:MF_01139}. CC -!- COFACTOR: CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420; CC Evidence={ECO:0000256|HAMAP-Rule:MF_01139}; CC Note=Binds 2 magnesium ions per subunit. {ECO:0000256|HAMAP- CC Rule:MF_01139}; CC -!- SUBUNIT: Homodimer. {ECO:0000256|HAMAP-Rule:MF_01139}. CC -!- SIMILARITY: Belongs to the UPP synthase family. {ECO:0000256|HAMAP- CC Rule:MF_01139}. CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ CC whole genome shotgun (WGS) entry which is preliminary data. CC {ECO:0000313|EMBL:TDG64357.1}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; PUFG01000025; TDG64357.1; -; Genomic_DNA. DR RefSeq; WP_035176398.1; NZ_PUFG01000025.1. DR AlphaFoldDB; A0A4R5N4G5; -. DR GeneID; 69669171; -. DR Proteomes; UP000295697; Unassembled WGS sequence. DR GO; GO:0000287; F:magnesium ion binding; IEA:UniProtKB-UniRule. DR GO; GO:0004659; F:prenyltransferase activity; IEA:UniProtKB-UniRule. DR CDD; cd00475; Cis_IPPS; 1. DR Gene3D; 3.40.1180.10; -; 1. DR HAMAP; MF_01139; ISPT; 1. DR InterPro; IPR001441; UPP_synth-like. DR InterPro; IPR018520; UPP_synth-like_CS. DR InterPro; IPR036424; UPP_synth-like_sf. DR PANTHER; PTHR10291; DEHYDRODOLICHYL DIPHOSPHATE SYNTHASE FAMILY MEMBER; 1. DR Pfam; PF01255; Prenyltransf; 1. DR SUPFAM; SSF64005; Undecaprenyl diphosphate synthase; 1. DR TIGRFAMs; TIGR00055; uppS; 1. DR PROSITE; PS01066; UPP_SYNTHASE; 1. PE 3: Inferred from homology; KW Magnesium {ECO:0000256|HAMAP-Rule:MF_01139}; KW Metal-binding {ECO:0000256|HAMAP-Rule:MF_01139}; KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|HAMAP- KW Rule:MF_01139}. FT ACT_SITE 15 FT /evidence="ECO:0000256|HAMAP-Rule:MF_01139" FT ACT_SITE 63 FT /note="Proton acceptor" FT /evidence="ECO:0000256|HAMAP-Rule:MF_01139" FT BINDING 15 FT /ligand="Mg(2+)" FT /ligand_id="ChEBI:CHEBI:18420" FT /evidence="ECO:0000256|HAMAP-Rule:MF_01139" FT BINDING 16..19 FT /ligand="substrate" FT /evidence="ECO:0000256|HAMAP-Rule:MF_01139" FT BINDING 20 FT /ligand="substrate" FT /evidence="ECO:0000256|HAMAP-Rule:MF_01139" FT BINDING 28 FT /ligand="substrate" FT /evidence="ECO:0000256|HAMAP-Rule:MF_01139" FT BINDING 32 FT /ligand="substrate" FT /evidence="ECO:0000256|HAMAP-Rule:MF_01139" FT BINDING 60..62 FT /ligand="substrate" FT /evidence="ECO:0000256|HAMAP-Rule:MF_01139" FT BINDING 64 FT /ligand="substrate" FT /evidence="ECO:0000256|HAMAP-Rule:MF_01139" FT BINDING 66 FT /ligand="substrate" FT /evidence="ECO:0000256|HAMAP-Rule:MF_01139" FT BINDING 186 FT /ligand="substrate" FT /evidence="ECO:0000256|HAMAP-Rule:MF_01139" FT BINDING 192..194 FT /ligand="substrate" FT /evidence="ECO:0000256|HAMAP-Rule:MF_01139" FT BINDING 205 FT /ligand="Mg(2+)" FT /ligand_id="ChEBI:CHEBI:18420" FT /evidence="ECO:0000256|HAMAP-Rule:MF_01139" SQ SEQUENCE 243 AA; 27660 MW; 1ABD64535C1D207C CRC64; MDKNKQLNHL AIIMDGNGRW AKKRKMPRFM GHKAGMDNVE KIALAADELG IKVLTLYAFS TENWARPKDE VNYLMNLPVK FFDKFMPRLQ AHNVKVNIMG YLDALPKSTR EVVERAMAET AANTGLVLNF AFNYGSRKEI VSAVQALVKE AASGEITPEE ITEDMVSAKL MTAKFAPYSD PDLLIRTSGE QRISNFLLWQ IAYSELAFTD KAWPDFDEND LAEMVKIYQH RDRRFGKLDE TDG //