ID A0A4P6PH65_9BACT Unreviewed; 755 AA. AC A0A4P6PH65; DT 31-JUL-2019, integrated into UniProtKB/TrEMBL. DT 31-JUL-2019, sequence version 1. DT 18-SEP-2019, entry version 2. DE RecName: Full=5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase {ECO:0000256|HAMAP-Rule:MF_00172, ECO:0000256|SAAS:SAAS01022781}; DE EC=2.1.1.14 {ECO:0000256|HAMAP-Rule:MF_00172}; DE AltName: Full=Cobalamin-independent methionine synthase {ECO:0000256|HAMAP-Rule:MF_00172}; DE AltName: Full=Methionine synthase, vitamin-B12 independent isozyme {ECO:0000256|HAMAP-Rule:MF_00172}; GN Name=metE {ECO:0000256|HAMAP-Rule:MF_00172, GN ECO:0000313|EMBL:QBG49077.1}; GN ORFNames=EGM51_17350 {ECO:0000313|EMBL:QBG49077.1}; OS Verrucomicrobia bacterium S94. OC Bacteria; Verrucomicrobia; unclassified Verrucomicrobia. OX NCBI_TaxID=2488809 {ECO:0000313|EMBL:QBG49077.1, ECO:0000313|Proteomes:UP000289135}; RN [1] {ECO:0000313|EMBL:QBG49077.1, ECO:0000313|Proteomes:UP000289135} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=S94 {ECO:0000313|EMBL:QBG49077.1, RC ECO:0000313|Proteomes:UP000289135}; RA Baek K.; RT "Verrucomicrobia bacterium S94."; RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Catalyzes the transfer of a methyl group from 5- CC methyltetrahydrofolate to homocysteine resulting in methionine CC formation. {ECO:0000256|HAMAP-Rule:MF_00172, CC ECO:0000256|SAAS:SAAS01022789}. CC -!- CATALYTIC ACTIVITY: CC Reaction=5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine CC = L-methionine + tetrahydropteroyltri-L-glutamate; CC Xref=Rhea:RHEA:21196, ChEBI:CHEBI:57844, ChEBI:CHEBI:58140, CC ChEBI:CHEBI:58199, ChEBI:CHEBI:58207; EC=2.1.1.14; CC Evidence={ECO:0000256|HAMAP-Rule:MF_00172, CC ECO:0000256|SAAS:SAAS01121619}; CC -!- COFACTOR: CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000256|HAMAP- CC Rule:MF_00172}; CC Note=Binds 1 zinc ion per subunit. {ECO:0000256|HAMAP- CC Rule:MF_00172}; CC -!- PATHWAY: Amino-acid biosynthesis; L-methionine biosynthesis via de CC novo pathway; L-methionine from L-homocysteine (MetE route): step CC 1/1. {ECO:0000256|HAMAP-Rule:MF_00172, CC ECO:0000256|SAAS:SAAS01022790}. CC -!- SIMILARITY: Belongs to the vitamin-B12 independent methionine CC synthase family. {ECO:0000256|HAMAP-Rule:MF_00172, CC ECO:0000256|SAAS:SAAS01026235}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CP036201; QBG49077.1; -; Genomic_DNA. DR UniPathway; UPA00051; UER00082. DR Proteomes; UP000289135; Chromosome. DR Gene3D; 3.20.20.210; -; 2. DR HAMAP; MF_00172; Meth_synth; 1. DR InterPro; IPR013215; Cbl-indep_Met_Synth_N. DR InterPro; IPR006276; Cobalamin-indep_Met_synthase. DR InterPro; IPR002629; Met_Synth_C/arc. DR InterPro; IPR038071; UROD/MetE-like_sf. DR Pfam; PF08267; Meth_synt_1; 1. DR Pfam; PF01717; Meth_synt_2; 1. DR PIRSF; PIRSF000382; MeTrfase_B12_ind; 1. DR SUPFAM; SSF51726; SSF51726; 2. DR TIGRFAMs; TIGR01371; met_syn_B12ind; 1. PE 3: Inferred from homology; KW Amino-acid biosynthesis {ECO:0000256|HAMAP-Rule:MF_00172, KW ECO:0000256|SAAS:SAAS01022777}; KW Complete proteome {ECO:0000313|Proteomes:UP000289135}; KW Metal-binding {ECO:0000256|HAMAP-Rule:MF_00172, KW ECO:0000256|SAAS:SAAS01026241}; KW Methionine biosynthesis {ECO:0000256|HAMAP-Rule:MF_00172, KW ECO:0000256|SAAS:SAAS01022782}; KW Methyltransferase {ECO:0000256|HAMAP-Rule:MF_00172, KW ECO:0000256|SAAS:SAAS01022778, ECO:0000313|EMBL:QBG49077.1}; KW Repeat {ECO:0000256|HAMAP-Rule:MF_00172}; KW Transferase {ECO:0000256|HAMAP-Rule:MF_00172, KW ECO:0000256|SAAS:SAAS01022783, ECO:0000313|EMBL:QBG49077.1}; KW Zinc {ECO:0000256|HAMAP-Rule:MF_00172, ECO:0000256|SAAS:SAAS01026239}. FT DOMAIN 3 307 Meth_synt_1. {ECO:0000259|Pfam:PF08267}. FT DOMAIN 426 747 Meth_synt_2. {ECO:0000259|Pfam:PF01717}. FT METAL 641 641 Zinc. {ECO:0000256|HAMAP-Rule:MF_00172}. FT METAL 643 643 Zinc. {ECO:0000256|HAMAP-Rule:MF_00172}. FT METAL 726 726 Zinc. {ECO:0000256|HAMAP-Rule:MF_00172}. SQ SEQUENCE 755 AA; 85517 MW; C853B36E6449CCDA CRC64; MKSHILGFPR IGSQRELKFA IEAYWRRACS ESELLLRTEQ IKLQNWTVQQ KAGLDYVCTG DFSLYDHVLD VSRMIGAVPA RFQTPGLSEL DIYFNMARGN AEAGIAPMEM TKWFDTNYHY IVPEIEADMQ LAYSSDTLVR ETEAALKQGF RPKPVVVGPL TYLALAKAAE GVNKWDALDA ITGVYSTLLE KLSGLTDCIQ LDEPILCTDL PTEIRERAEQ TYAVLRSHAR HTRLLLGTYF GGLNENLDLT ARLPVDVLHI DLVRAPGQLD DVLTKWPEHK DLSLGLIDGR NIWKADLAEL LKQIVKAKPT RHTDQLWIGS SCSLLHTPVS LEPETDLLPE LKAWMAFAVE KCSEVKTLTL AAQGCNVNEE LLENKKIISS RKNSPLSLDF EVRKRVEQVD ARMCRRARPF AERKKCQQAR LNLPLLPTTT IGSFPQTKEI RNIRKAFRNG DCDQSAYTQA MQQEICSVIQ EQELAGLDVL VHGEPERNDM VEYFGQQMNG FCFSQYGWVQ SYGSRCVKPP IIYGDVSRPA PMTLDWIQYA QSQTEKPLKG MLTGPVTMLC WSFVRDDLPR AAVCRQIALA IRDEVLDLEK AGIGMIQIDE AAFREGLPIR KDEQEEYLNW AVENFRLATS GVRDETQIHT HMCYSEFNTI LQEIAAMDAD VISIEASRSD MELLQAFETF HYPNDIGPGV WDIHSPRVPS VTEIRTLIEN ALKVIPKEQL WINPDCGLKT RGWPETRQAL RNMVEATTAV RKILQ //