ID   A0A4P6PH65_9BACT        Unreviewed;       755 AA.
AC   A0A4P6PH65;
DT   31-JUL-2019, integrated into UniProtKB/TrEMBL.
DT   31-JUL-2019, sequence version 1.
DT   18-SEP-2019, entry version 2.
DE   RecName: Full=5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase {ECO:0000256|HAMAP-Rule:MF_00172, ECO:0000256|SAAS:SAAS01022781};
DE            EC=2.1.1.14 {ECO:0000256|HAMAP-Rule:MF_00172};
DE   AltName: Full=Cobalamin-independent methionine synthase {ECO:0000256|HAMAP-Rule:MF_00172};
DE   AltName: Full=Methionine synthase, vitamin-B12 independent isozyme {ECO:0000256|HAMAP-Rule:MF_00172};
GN   Name=metE {ECO:0000256|HAMAP-Rule:MF_00172,
GN   ECO:0000313|EMBL:QBG49077.1};
GN   ORFNames=EGM51_17350 {ECO:0000313|EMBL:QBG49077.1};
OS   Verrucomicrobia bacterium S94.
OC   Bacteria; Verrucomicrobia; unclassified Verrucomicrobia.
OX   NCBI_TaxID=2488809 {ECO:0000313|EMBL:QBG49077.1, ECO:0000313|Proteomes:UP000289135};
RN   [1] {ECO:0000313|EMBL:QBG49077.1, ECO:0000313|Proteomes:UP000289135}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=S94 {ECO:0000313|EMBL:QBG49077.1,
RC   ECO:0000313|Proteomes:UP000289135};
RA   Baek K.;
RT   "Verrucomicrobia bacterium S94.";
RL   Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Catalyzes the transfer of a methyl group from 5-
CC       methyltetrahydrofolate to homocysteine resulting in methionine
CC       formation. {ECO:0000256|HAMAP-Rule:MF_00172,
CC       ECO:0000256|SAAS:SAAS01022789}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine
CC         = L-methionine + tetrahydropteroyltri-L-glutamate;
CC         Xref=Rhea:RHEA:21196, ChEBI:CHEBI:57844, ChEBI:CHEBI:58140,
CC         ChEBI:CHEBI:58199, ChEBI:CHEBI:58207; EC=2.1.1.14;
CC         Evidence={ECO:0000256|HAMAP-Rule:MF_00172,
CC         ECO:0000256|SAAS:SAAS01121619};
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000256|HAMAP-
CC         Rule:MF_00172};
CC       Note=Binds 1 zinc ion per subunit. {ECO:0000256|HAMAP-
CC       Rule:MF_00172};
CC   -!- PATHWAY: Amino-acid biosynthesis; L-methionine biosynthesis via de
CC       novo pathway; L-methionine from L-homocysteine (MetE route): step
CC       1/1. {ECO:0000256|HAMAP-Rule:MF_00172,
CC       ECO:0000256|SAAS:SAAS01022790}.
CC   -!- SIMILARITY: Belongs to the vitamin-B12 independent methionine
CC       synthase family. {ECO:0000256|HAMAP-Rule:MF_00172,
CC       ECO:0000256|SAAS:SAAS01026235}.
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DR   EMBL; CP036201; QBG49077.1; -; Genomic_DNA.
DR   UniPathway; UPA00051; UER00082.
DR   Proteomes; UP000289135; Chromosome.
DR   Gene3D; 3.20.20.210; -; 2.
DR   HAMAP; MF_00172; Meth_synth; 1.
DR   InterPro; IPR013215; Cbl-indep_Met_Synth_N.
DR   InterPro; IPR006276; Cobalamin-indep_Met_synthase.
DR   InterPro; IPR002629; Met_Synth_C/arc.
DR   InterPro; IPR038071; UROD/MetE-like_sf.
DR   Pfam; PF08267; Meth_synt_1; 1.
DR   Pfam; PF01717; Meth_synt_2; 1.
DR   PIRSF; PIRSF000382; MeTrfase_B12_ind; 1.
DR   SUPFAM; SSF51726; SSF51726; 2.
DR   TIGRFAMs; TIGR01371; met_syn_B12ind; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis {ECO:0000256|HAMAP-Rule:MF_00172,
KW   ECO:0000256|SAAS:SAAS01022777};
KW   Complete proteome {ECO:0000313|Proteomes:UP000289135};
KW   Metal-binding {ECO:0000256|HAMAP-Rule:MF_00172,
KW   ECO:0000256|SAAS:SAAS01026241};
KW   Methionine biosynthesis {ECO:0000256|HAMAP-Rule:MF_00172,
KW   ECO:0000256|SAAS:SAAS01022782};
KW   Methyltransferase {ECO:0000256|HAMAP-Rule:MF_00172,
KW   ECO:0000256|SAAS:SAAS01022778, ECO:0000313|EMBL:QBG49077.1};
KW   Repeat {ECO:0000256|HAMAP-Rule:MF_00172};
KW   Transferase {ECO:0000256|HAMAP-Rule:MF_00172,
KW   ECO:0000256|SAAS:SAAS01022783, ECO:0000313|EMBL:QBG49077.1};
KW   Zinc {ECO:0000256|HAMAP-Rule:MF_00172, ECO:0000256|SAAS:SAAS01026239}.
FT   DOMAIN        3    307       Meth_synt_1. {ECO:0000259|Pfam:PF08267}.
FT   DOMAIN      426    747       Meth_synt_2. {ECO:0000259|Pfam:PF01717}.
FT   METAL       641    641       Zinc. {ECO:0000256|HAMAP-Rule:MF_00172}.
FT   METAL       643    643       Zinc. {ECO:0000256|HAMAP-Rule:MF_00172}.
FT   METAL       726    726       Zinc. {ECO:0000256|HAMAP-Rule:MF_00172}.
SQ   SEQUENCE   755 AA;  85517 MW;  C853B36E6449CCDA CRC64;
     MKSHILGFPR IGSQRELKFA IEAYWRRACS ESELLLRTEQ IKLQNWTVQQ KAGLDYVCTG
     DFSLYDHVLD VSRMIGAVPA RFQTPGLSEL DIYFNMARGN AEAGIAPMEM TKWFDTNYHY
     IVPEIEADMQ LAYSSDTLVR ETEAALKQGF RPKPVVVGPL TYLALAKAAE GVNKWDALDA
     ITGVYSTLLE KLSGLTDCIQ LDEPILCTDL PTEIRERAEQ TYAVLRSHAR HTRLLLGTYF
     GGLNENLDLT ARLPVDVLHI DLVRAPGQLD DVLTKWPEHK DLSLGLIDGR NIWKADLAEL
     LKQIVKAKPT RHTDQLWIGS SCSLLHTPVS LEPETDLLPE LKAWMAFAVE KCSEVKTLTL
     AAQGCNVNEE LLENKKIISS RKNSPLSLDF EVRKRVEQVD ARMCRRARPF AERKKCQQAR
     LNLPLLPTTT IGSFPQTKEI RNIRKAFRNG DCDQSAYTQA MQQEICSVIQ EQELAGLDVL
     VHGEPERNDM VEYFGQQMNG FCFSQYGWVQ SYGSRCVKPP IIYGDVSRPA PMTLDWIQYA
     QSQTEKPLKG MLTGPVTMLC WSFVRDDLPR AAVCRQIALA IRDEVLDLEK AGIGMIQIDE
     AAFREGLPIR KDEQEEYLNW AVENFRLATS GVRDETQIHT HMCYSEFNTI LQEIAAMDAD
     VISIEASRSD MELLQAFETF HYPNDIGPGV WDIHSPRVPS VTEIRTLIEN ALKVIPKEQL
     WINPDCGLKT RGWPETRQAL RNMVEATTAV RKILQ
//