ID A0A4P2VFJ5_9POLY Unreviewed; 799 AA. AC A0A4P2VFJ5; A0A4P2VJ04; DT 31-JUL-2019, integrated into UniProtKB/TrEMBL. DT 22-APR-2020, sequence version 2. DT 12-AUG-2020, entry version 8. DE RecName: Full=Large T antigen {ECO:0000256|ARBA:ARBA00018805}; GN Name=LTAg {ECO:0000313|EMBL:BBG62133.2}; OS Rhinolophus affinis polyomavirus 1. OC Viruses; Monodnaviria; Shotokuvirae; Cossaviricota; Papovaviricetes; OC Sepolyvirales; Polyomaviridae; unclassified Polyomaviridae. OX NCBI_TaxID=2447809 {ECO:0000313|EMBL:BBG62133.2}; RN [1] {ECO:0000313|EMBL:BBG62133.2} RP NUCLEOTIDE SEQUENCE. RC STRAIN=PyV22-DXC12 {ECO:0000313|EMBL:BBG62133.2}, PyVB-FN02C RC {ECO:0000313|EMBL:BBG62006.2}, and PyVB-FN04C RC {ECO:0000313|EMBL:BBG62011.2}; RA Tan Z., Gonzalez G., Xu L., Zhang P., Zhu A., He B., Carr M., Tu C.; RT "Extensive diversity of polyomaviruses in Chinese bats and evidence of RT intra- and inter-genera host-switching in their hosts."; RL Submitted (SEP-2018) to the EMBL/GenBank/DDBJ databases. CC -!- SUBCELLULAR LOCATION: Host nucleus {ECO:0000256|ARBA:ARBA00004147}. CC Nucleus {ECO:0000256|ARBA:ARBA00004123}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; LC426678; BBG62006.2; -; Genomic_DNA. DR EMBL; LC426679; BBG62011.2; -; Genomic_DNA. DR EMBL; LC426701; BBG62133.2; -; Genomic_DNA. DR GO; GO:0005524; F:ATP binding; IEA:InterPro. DR GO; GO:0003688; F:DNA replication origin binding; IEA:InterPro. DR GO; GO:0006260; P:DNA replication; IEA:InterPro. DR CDD; cd06257; DnaJ; 1. DR Gene3D; 1.10.287.110; -; 1. DR Gene3D; 1.20.120.1860; -; 1. DR InterPro; IPR001623; DnaJ_domain. DR InterPro; IPR036869; J_dom_sf. DR InterPro; IPR010932; Lg_T_Ag_Polyomavir_C. DR InterPro; IPR027417; P-loop_NTPase. DR InterPro; IPR003354; Papo_T_antigen. DR InterPro; IPR036092; Papo_T_antigensf. DR InterPro; IPR003133; T_Ag_DNA-bd. DR Pfam; PF02380; Papo_T_antigen; 1. DR Pfam; PF06431; Polyoma_lg_T_C; 1. DR Pfam; PF02217; T_Ag_DNA_bind; 1. DR SMART; SM00271; DnaJ; 1. DR SUPFAM; SSF161240; SSF161240; 1. DR SUPFAM; SSF46565; SSF46565; 1. DR SUPFAM; SSF52540; SSF52540; 1. PE 4: Predicted; KW ATP-binding {ECO:0000256|ARBA:ARBA00022840}; KW Early protein {ECO:0000256|ARBA:ARBA00022518}; KW G1/S host cell cycle checkpoint dysregulation by virus KW {ECO:0000256|ARBA:ARBA00023309}; KW Host nucleus {ECO:0000256|ARBA:ARBA00022562}; KW Host-virus interaction {ECO:0000256|ARBA:ARBA00022581}; KW Hydrolase {ECO:0000256|ARBA:ARBA00022801}; KW Inhibition of host innate immune response by virus KW {ECO:0000256|ARBA:ARBA00022632}; KW Inhibition of host interferon signaling pathway by virus KW {ECO:0000256|ARBA:ARBA00022830}; KW Inhibition of host JAK1 by virus {ECO:0000256|ARBA:ARBA00023318}; KW Modulation of host cell cycle by virus {ECO:0000256|ARBA:ARBA00022504}; KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022840}; KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553}; KW Viral immunoevasion {ECO:0000256|ARBA:ARBA00023280}. FT DOMAIN 11..67 FT /note="J" FT /evidence="ECO:0000259|SMART:SM00271" FT REGION 232..277 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 769..799 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 232..250 FT /note="Polyampholyte" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 251..269 FT /note="Polar" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 769..784 FT /note="Acidic" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 785..799 FT /note="Polar" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 799 AA; 92638 MW; 51160A2873A2175B CRC64; MDKFLSRQEM TELMELLQVP MHCYGNLPMM KINYKKMCKS YHPDKGGDEN KMKRLNELWQ KLQDNVCSAR QEYPRDQVNF WFWEDDFPTC GEYLGPKFAS KLCKAYPECV KYPKQDCGCL VCLLDKQHHI YKEVRQKRCL VWGECFCYSC YLNWFGFPNT TECFNWWGNI IHATDLQLLN VIGSQHWGNL YLQPSSQGTS SPRPPPYGSS SWEQWWHDFN KEWDDLFCDE SISSSDEDDH PRRRSSRNSP EPDGRNCPGS SQGSFATPPK PKKQKTFHVP KDFPRELDSF LSNAVYSNKT VCSFLIYTTK EKADFLYNQL EKFKPEFKSK HSYEDAALVF IMTPSKHRVS AIKNFCATHC TVSFLLCKAV IKPVDCYRAL CSEPFSLVEE NKPGIYEFQF EEEKQPSVDW NKIAEFAELN RLDDPLVIMG FYLDFASDPG LCIKCNKQTL KMHFKYHDKH HKNAMLFKDS KAQKNICQQA ADVVIAKRRV KVIECTRKEL LSERFQLHFE KLADIFSDTQ LHYYMAGVAW YTCLFEHIDE IVFKILKLLV ENVPKKRNIL FRGPINSGKT TLAAAILDLV GGKTLNVNCP AEKLPFELGC AIDQFAVVFE DVKGQIALNK NLQPGQGVCN LDNLRDYLDG SVKVNLEKKH VNKKSQIFPP CITTMNDYML PQTLYARYAY IVNFSPKDHL KKSLEANDDL MTKRVLQSGI TILLMMVYYL PTSSFTEDIQ ETVTNWKQTI DKYVGYGKLL DMQGNILQGR DPLEGILYDY EDEEQEEEEQ QEQNTENTND SGINTQQTV //