ID A0A4P2VFJ5_9POLY Unreviewed; 799 AA. AC A0A4P2VFJ5; A0A4P2VJ04; DT 31-JUL-2019, integrated into UniProtKB/TrEMBL. DT 22-APR-2020, sequence version 2. DT 22-APR-2020, entry version 6. DE SubName: Full=Large T antigen {ECO:0000313|EMBL:BBG62133.2}; GN Name=LTAg {ECO:0000313|EMBL:BBG62133.2}; OS Rhinolophus affinis polyomavirus 1. OC Viruses; Polyomaviridae; unclassified Polyomaviridae. OX NCBI_TaxID=2447809 {ECO:0000313|EMBL:BBG62133.2}; RN [1] {ECO:0000313|EMBL:BBG62133.2} RP NUCLEOTIDE SEQUENCE. RC STRAIN=PyV22-DXC12 {ECO:0000313|EMBL:BBG62133.2}, PyVB-FN02C RC {ECO:0000313|EMBL:BBG62006.2}, and PyVB-FN04C RC {ECO:0000313|EMBL:BBG62011.2}; RA Tan Z., Gonzalez G., Xu L., Zhang P., Zhu A., He B., Carr M., Tu C.; RT "Extensive diversity of polyomaviruses in Chinese bats and evidence of RT intra- and inter-genera host-switching in their hosts."; RL Submitted (SEP-2018) to the EMBL/GenBank/DDBJ databases. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; LC426678; BBG62006.2; -; Genomic_DNA. DR EMBL; LC426679; BBG62011.2; -; Genomic_DNA. DR EMBL; LC426701; BBG62133.2; -; Genomic_DNA. DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW. DR GO; GO:0003688; F:DNA replication origin binding; IEA:InterPro. DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW. DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW. DR CDD; cd06257; DnaJ; 1. DR Gene3D; 1.10.287.110; -; 1. DR Gene3D; 1.20.120.1860; -; 1. DR InterPro; IPR001623; DnaJ_domain. DR InterPro; IPR014015; Helicase_SF3_DNA-vir. DR InterPro; IPR036869; J_dom_sf. DR InterPro; IPR016392; Lg_T_Ag_polyomavir. DR InterPro; IPR010932; Lg_T_Ag_Polyomavir_C. DR InterPro; IPR027417; P-loop_NTPase. DR InterPro; IPR003354; Papo_T_antigen. DR InterPro; IPR036092; Papo_T_antigensf. DR InterPro; IPR003133; T_Ag_DNA-bd. DR InterPro; IPR017910; Znf_lg_T-Ag_D1-typ. DR Pfam; PF02380; Papo_T_antigen; 1. DR Pfam; PF06431; Polyoma_lg_T_C; 1. DR Pfam; PF02217; T_Ag_DNA_bind; 1. DR PIRSF; PIRSF003368; Large_T_antigen_polyomaV; 1. DR SMART; SM00271; DnaJ; 1. DR SUPFAM; SSF161240; SSF161240; 1. DR SUPFAM; SSF46565; SSF46565; 1. DR SUPFAM; SSF52540; SSF52540; 1. DR PROSITE; PS50076; DNAJ_2; 1. DR PROSITE; PS51206; SF3_HELICASE_1; 1. DR PROSITE; PS51287; T_AG_OBD; 1. DR PROSITE; PS51341; ZF_LTAG_D1; 1. PE 4: Predicted; KW ATP-binding {ECO:0000256|SAAS:SAAS01105244}; KW DNA replication {ECO:0000256|SAAS:SAAS01105238}; KW DNA-binding {ECO:0000256|PROSITE-ProRule:PRU00620}; KW Hydrolase {ECO:0000256|SAAS:SAAS00150732}; KW Nucleotide-binding {ECO:0000256|SAAS:SAAS01105243}. FT DOMAIN 12..77 FT /note="J" FT /evidence="ECO:0000259|PROSITE:PS50076" FT DOMAIN 180..294 FT /note="T-ag OBD" FT /evidence="ECO:0000259|PROSITE:PS51287" FT DOMAIN 301..393 FT /note="T-ag D1-type" FT /evidence="ECO:0000259|PROSITE:PS51341" FT DOMAIN 433..593 FT /note="SF3 helicase" FT /evidence="ECO:0000259|PROSITE:PS51206" FT DNA_BIND 180..294 FT /note="T-ag OBD" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00620" FT REGION 133..173 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 665..695 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 147..165 FT /note="Polar" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 665..680 FT /note="Acidic" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 681..695 FT /note="Polar" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 799 AA; 92638 MW; 51160A2873A2175B CRC64; MDKFLSRQEM TELMELLQVP MHCYGNLPMM KINYKKMCKS YHPDKGGDEN KMKRLNELWQ KLQDNVCSAR QEYPRDQVNF WFWEDDFPTC GEYLGPKFAS KLCKAYPECV KYPKQDCGCL VCLLDKQHHI YKEVRQKRCL VWGECFCYSC YLNWFGFPNT TECFNWWGNI IHATDLQLLN VIGSQHWGNL YLQPSSQGTS SPRPPPYGSS SWEQWWHDFN KEWDDLFCDE SISSSDEDDH PRRRSSRNSP EPDGRNCPGS SQGSFATPPK PKKQKTFHVP KDFPRELDSF LSNAVYSNKT VCSFLIYTTK EKADFLYNQL EKFKPEFKSK HSYEDAALVF IMTPSKHRVS AIKNFCATHC TVSFLLCKAV IKPVDCYRAL CSEPFSLVEE NKPGIYEFQF EEEKQPSVDW NKIAEFAELN RLDDPLVIMG FYLDFASDPG LCIKCNKQTL KMHFKYHDKH HKNAMLFKDS KAQKNICQQA ADVVIAKRRV KVIECTRKEL LSERFQLHFE KLADIFSDTQ LHYYMAGVAW YTCLFEHIDE IVFKILKLLV ENVPKKRNIL FRGPINSGKT TLAAAILDLV GGKTLNVNCP AEKLPFELGC AIDQFAVVFE DVKGQIALNK NLQPGQGVCN LDNLRDYLDG SVKVNLEKKH VNKKSQIFPP CITTMNDYML PQTLYARYAY IVNFSPKDHL KKSLEANDDL MTKRVLQSGI TILLMMVYYL PTSSFTEDIQ ETVTNWKQTI DKYVGYGKLL DMQGNILQGR DPLEGILYDY EDEEQEEEEQ QEQNTENTND SGINTQQTV //