ID A0A4P2VFJ5_9POLY Unreviewed; 799 AA. AC A0A4P2VFJ5; A0A4P2VJ04; DT 31-JUL-2019, integrated into UniProtKB/TrEMBL. DT 22-APR-2020, sequence version 2. DT 03-AUG-2022, entry version 15. DE RecName: Full=Large T antigen {ECO:0000256|ARBA:ARBA00018805}; GN Name=LTAg {ECO:0000313|EMBL:BBG62133.2}; OS Rhinolophus affinis polyomavirus 1. OC Viruses; Monodnaviria; Shotokuvirae; Cossaviricota; Papovaviricetes; OC Sepolyvirales; Polyomaviridae; unclassified Polyomaviridae. OX NCBI_TaxID=2447809 {ECO:0000313|EMBL:BBG62133.2}; RN [1] {ECO:0000313|EMBL:BBG62133.2} RP NUCLEOTIDE SEQUENCE. RC STRAIN=PyV22-DXC12 {ECO:0000313|EMBL:BBG62133.2}, PyVB-FN02C RC {ECO:0000313|EMBL:BBG62006.2}, and PyVB-FN04C RC {ECO:0000313|EMBL:BBG62011.2}; RA Tan Z., Gonzalez G., Xu L., Zhang P., Zhu A., He B., Carr M., Tu C.; RT "Extensive diversity of polyomaviruses in Chinese bats and evidence of RT intra- and inter-genera host-switching in their hosts."; RL Submitted (SEP-2018) to the EMBL/GenBank/DDBJ databases. CC -!- SUBCELLULAR LOCATION: Host nucleus {ECO:0000256|ARBA:ARBA00004147}. CC Nucleus {ECO:0000256|ARBA:ARBA00004123}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; LC426678; BBG62006.2; -; Genomic_DNA. DR EMBL; LC426679; BBG62011.2; -; Genomic_DNA. DR EMBL; LC426701; BBG62133.2; -; Genomic_DNA. DR GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell. DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW. DR GO; GO:0003688; F:DNA replication origin binding; IEA:InterPro. DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW. DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. DR GO; GO:0006260; P:DNA replication; IEA:InterPro. DR GO; GO:0039645; P:modulation by virus of host G1/S transition checkpoint; IEA:UniProtKB-KW. DR GO; GO:0039576; P:suppression by virus of host JAK-STAT cascade via inhibition of JAK1 activity; IEA:UniProtKB-KW. DR GO; GO:0039502; P:suppression by virus of host type I interferon-mediated signaling pathway; IEA:UniProtKB-KW. DR CDD; cd06257; DnaJ; 1. DR Gene3D; 1.10.10.510; -; 1. DR Gene3D; 1.10.287.110; -; 1. DR Gene3D; 1.20.120.1860; -; 1. DR Gene3D; 3.40.50.300; -; 1. DR InterPro; IPR001623; DnaJ_domain. DR InterPro; IPR014015; Helicase_SF3_DNA-vir. DR InterPro; IPR036869; J_dom_sf. DR InterPro; IPR010932; Lg_T_Ag_Polyomavir_C. DR InterPro; IPR027417; P-loop_NTPase. DR InterPro; IPR003354; Papo_T_antigen. DR InterPro; IPR036092; Papo_T_antigensf. DR InterPro; IPR003133; T_Ag_DNA-bd. DR InterPro; IPR017910; Znf_lg_T-Ag_D1-typ. DR InterPro; IPR037102; Znf_lg_T-Ag_D1_dom_sf. DR Pfam; PF02380; Papo_T_antigen; 1. DR Pfam; PF06431; Polyoma_lg_T_C; 1. DR Pfam; PF02217; T_Ag_DNA_bind; 1. DR SMART; SM00271; DnaJ; 1. DR SUPFAM; SSF161240; SSF161240; 1. DR SUPFAM; SSF46565; SSF46565; 1. DR SUPFAM; SSF52540; SSF52540; 1. DR PROSITE; PS50076; DNAJ_2; 1. DR PROSITE; PS51206; SF3_HELICASE_1; 1. DR PROSITE; PS51287; T_AG_OBD; 1. DR PROSITE; PS51341; ZF_LTAG_D1; 1. PE 4: Predicted; KW ATP-binding {ECO:0000256|ARBA:ARBA00022840}; KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE- KW ProRule:PRU00620}; Early protein {ECO:0000256|ARBA:ARBA00022518}; KW G1/S host cell cycle checkpoint dysregulation by virus KW {ECO:0000256|ARBA:ARBA00023309}; KW Host nucleus {ECO:0000256|ARBA:ARBA00022562}; KW Host-virus interaction {ECO:0000256|ARBA:ARBA00022581}; KW Hydrolase {ECO:0000256|ARBA:ARBA00022801}; KW Inhibition of host innate immune response by virus KW {ECO:0000256|ARBA:ARBA00022632}; KW Inhibition of host interferon signaling pathway by virus KW {ECO:0000256|ARBA:ARBA00022830}; KW Inhibition of host JAK1 by virus {ECO:0000256|ARBA:ARBA00023318}; KW Metal-binding {ECO:0000256|ARBA:ARBA00022723}; KW Modulation of host cell cycle by virus {ECO:0000256|ARBA:ARBA00022504}; KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}; KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553}; KW Viral immunoevasion {ECO:0000256|ARBA:ARBA00023280}; KW Zinc {ECO:0000256|ARBA:ARBA00022833}; KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE- KW ProRule:PRU00671}. FT DOMAIN 12..77 FT /note="J" FT /evidence="ECO:0000259|PROSITE:PS50076" FT DOMAIN 284..398 FT /note="T-ag OBD" FT /evidence="ECO:0000259|PROSITE:PS51287" FT DOMAIN 405..497 FT /note="T-ag D1-type" FT /evidence="ECO:0000259|PROSITE:PS51341" FT DOMAIN 537..697 FT /note="SF3 helicase" FT /evidence="ECO:0000259|PROSITE:PS51206" FT DNA_BIND 284..398 FT /note="T-ag OBD" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00620" FT REGION 232..277 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 769..799 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 232..250 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 251..269 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 769..784 FT /note="Acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 785..799 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 799 AA; 92638 MW; 51160A2873A2175B CRC64; MDKFLSRQEM TELMELLQVP MHCYGNLPMM KINYKKMCKS YHPDKGGDEN KMKRLNELWQ KLQDNVCSAR QEYPRDQVNF WFWEDDFPTC GEYLGPKFAS KLCKAYPECV KYPKQDCGCL VCLLDKQHHI YKEVRQKRCL VWGECFCYSC YLNWFGFPNT TECFNWWGNI IHATDLQLLN VIGSQHWGNL YLQPSSQGTS SPRPPPYGSS SWEQWWHDFN KEWDDLFCDE SISSSDEDDH PRRRSSRNSP EPDGRNCPGS SQGSFATPPK PKKQKTFHVP KDFPRELDSF LSNAVYSNKT VCSFLIYTTK EKADFLYNQL EKFKPEFKSK HSYEDAALVF IMTPSKHRVS AIKNFCATHC TVSFLLCKAV IKPVDCYRAL CSEPFSLVEE NKPGIYEFQF EEEKQPSVDW NKIAEFAELN RLDDPLVIMG FYLDFASDPG LCIKCNKQTL KMHFKYHDKH HKNAMLFKDS KAQKNICQQA ADVVIAKRRV KVIECTRKEL LSERFQLHFE KLADIFSDTQ LHYYMAGVAW YTCLFEHIDE IVFKILKLLV ENVPKKRNIL FRGPINSGKT TLAAAILDLV GGKTLNVNCP AEKLPFELGC AIDQFAVVFE DVKGQIALNK NLQPGQGVCN LDNLRDYLDG SVKVNLEKKH VNKKSQIFPP CITTMNDYML PQTLYARYAY IVNFSPKDHL KKSLEANDDL MTKRVLQSGI TILLMMVYYL PTSSFTEDIQ ETVTNWKQTI DKYVGYGKLL DMQGNILQGR DPLEGILYDY EDEEQEEEEQ QEQNTENTND SGINTQQTV //