ID A0A4D7K596_9BACT Unreviewed; 245 AA. AC A0A4D7K596; DT 31-JUL-2019, integrated into UniProtKB/TrEMBL. DT 31-JUL-2019, sequence version 1. DT 18-SEP-2019, entry version 2. DE RecName: Full=1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase {ECO:0000256|HAMAP-Rule:MF_01014, ECO:0000256|RuleBase:RU003658, ECO:0000256|SAAS:SAAS00727989}; DE EC=5.3.1.16 {ECO:0000256|HAMAP-Rule:MF_01014, ECO:0000256|RuleBase:RU003658, ECO:0000256|SAAS:SAAS00015920}; DE AltName: Full=Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase {ECO:0000256|HAMAP-Rule:MF_01014}; GN Name=hisA {ECO:0000256|HAMAP-Rule:MF_01014, GN ECO:0000313|EMBL:QCK16004.1}; GN ORFNames=DCC35_15285 {ECO:0000313|EMBL:QCK16004.1}; OS Fabibacter pacificus. OC Bacteria; Bacteroidetes; Cytophagia; Cytophagales; Flammeovirgaceae; OC Fabibacter. OX NCBI_TaxID=1267423 {ECO:0000313|EMBL:QCK16004.1, ECO:0000313|Proteomes:UP000298616}; RN [1] {ECO:0000313|EMBL:QCK16004.1, ECO:0000313|Proteomes:UP000298616} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=9dcg1 {ECO:0000313|EMBL:QCK16004.1, RC ECO:0000313|Proteomes:UP000298616}; RA Merlino G.; RT "Complete genome uncultured novel isolate."; RL Submitted (APR-2018) to the EMBL/GenBank/DDBJ databases. CC -!- CATALYTIC ACTIVITY: CC Reaction=1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D- CC ribosylamino)methylideneamino]imidazole-4-carboxamide = 5-[(5- CC phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho- CC beta-D-ribosyl)imidazole-4-carboxamide; Xref=Rhea:RHEA:15469, CC ChEBI:CHEBI:58435, ChEBI:CHEBI:58525; EC=5.3.1.16; CC Evidence={ECO:0000256|HAMAP-Rule:MF_01014, CC ECO:0000256|RuleBase:RU003658, ECO:0000256|SAAS:SAAS01118349}; CC -!- PATHWAY: Amino-acid biosynthesis; L-histidine biosynthesis; L- CC histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 4/9. CC {ECO:0000256|HAMAP-Rule:MF_01014, ECO:0000256|RuleBase:RU003658, CC ECO:0000256|SAAS:SAAS00015865}. CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_01014, CC ECO:0000256|RuleBase:RU003658, ECO:0000256|SAAS:SAAS00345444}. CC -!- SIMILARITY: Belongs to the HisA/HisF family. {ECO:0000256|HAMAP- CC Rule:MF_01014, ECO:0000256|RuleBase:RU003657, CC ECO:0000256|SAAS:SAAS00541187}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CP028923; QCK16004.1; -; Genomic_DNA. DR UniPathway; UPA00031; UER00009. DR Proteomes; UP000298616; Chromosome. DR CDD; cd04732; HisA; 1. DR Gene3D; 3.20.20.70; -; 1. DR HAMAP; MF_01014; HisA; 1. DR InterPro; IPR013785; Aldolase_TIM. DR InterPro; IPR006062; His_biosynth. DR InterPro; IPR006063; HisA. DR InterPro; IPR023016; Isoase_HisA. DR InterPro; IPR011060; RibuloseP-bd_barrel. DR Pfam; PF00977; His_biosynth; 1. DR SUPFAM; SSF51366; SSF51366; 1. DR TIGRFAMs; TIGR00007; TIGR00007; 1. PE 3: Inferred from homology; KW Amino-acid biosynthesis {ECO:0000256|HAMAP-Rule:MF_01014, KW ECO:0000256|RuleBase:RU003657, ECO:0000256|SAAS:SAAS00015854}; KW Complete proteome {ECO:0000313|Proteomes:UP000298616}; KW Cytoplasm {ECO:0000256|HAMAP-Rule:MF_01014, KW ECO:0000256|RuleBase:RU003658, ECO:0000256|SAAS:SAAS00423700}; KW Histidine biosynthesis {ECO:0000256|HAMAP-Rule:MF_01014, KW ECO:0000256|RuleBase:RU003657, ECO:0000256|SAAS:SAAS00423728}; KW Isomerase {ECO:0000256|HAMAP-Rule:MF_01014, KW ECO:0000256|RuleBase:RU003658, ECO:0000256|SAAS:SAAS00423732, KW ECO:0000313|EMBL:QCK16004.1}. FT ACT_SITE 10 10 Proton acceptor. {ECO:0000256|HAMAP-Rule: FT MF_01014}. FT ACT_SITE 132 132 Proton donor. {ECO:0000256|HAMAP-Rule: FT MF_01014}. SQ SEQUENCE 245 AA; 26983 MW; 8D5BA4289010F8DE CRC64; METRLIPAID IIEGKCVRLT QGDYGKKTVY NEDPVEVARE FLDNGLKNLH LVDLDGARNK QIVNLKVLEK IASLDGLHVD FGGGIKRDQD ATDAFNAGAD QITGGSIAAK EPETFLRWLE KYGSKKIILG ADARDKMIAT SGWEEKSELE VTDFINDYEK KGVEYVICTD VAKDGLLQGP SFDLYKEIMT KTSKTRLIAS GGVSGIDDIK DLIAMEVEGI IIGKAIYENK VSLKQLSQII LEQNA //