ID A0A498U6I0_MOUSE Unreviewed; 287 AA. AC A0A498U6I0; DT 05-JUN-2019, integrated into UniProtKB/TrEMBL. DT 05-JUN-2019, sequence version 1. DT 27-NOV-2024, entry version 29. DE SubName: Full=Histocompatibility 2, class II antigen E beta {ECO:0000313|Ensembl:ENSMUSP00000074143.10}; DE Flags: Fragment; GN Name=H2-Eb1 {ECO:0000313|Ensembl:ENSMUSP00000074143.10, GN ECO:0000313|MGI:MGI:95901}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000074143.10, ECO:0000313|Proteomes:UP000000589}; RN [1] {ECO:0000313|Ensembl:ENSMUSP00000074143.10, ECO:0000313|Proteomes:UP000000589} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000074143.10, RC ECO:0000313|Proteomes:UP000000589}; RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112; RG Mouse Genome Sequencing Consortium; RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S., RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., RA Eichler E.E., Ponting C.P.; RT "Lineage-specific biology revealed by a finished genome assembly of the RT mouse."; RL PLoS Biol. 7:E1000112-E1000112(2009). RN [2] {ECO:0000313|Ensembl:ENSMUSP00000074143.10} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000074143.10}; RX PubMed=21750661; RA Church D.M., Schneider V.A., Graves T., Auger K., Cunningham F., Bouk N., RA Chen H.C., Agarwala R., McLaren W.M., Ritchie G.R., Albracht D., RA Kremitzki M., Rock S., Kotkiewicz H., Kremitzki C., Wollam A., Trani L., RA Fulton L., Fulton R., Matthews L., Whitehead S., Chow W., Torrance J., RA Dunn M., Harden G., Threadgold G., Wood J., Collins J., Heath P., RA Griffiths G., Pelan S., Grafham D., Eichler E.E., Weinstock G., RA Mardis E.R., Wilson R.K., Howe K., Flicek P., Hubbard T.; RT "Modernizing reference genome assemblies."; RL PLoS Biol. 9:e1001091-e1001091(2011). RN [3] {ECO:0000313|Ensembl:ENSMUSP00000074143.10} RP IDENTIFICATION. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000074143.10}; RG Ensembl; RL Submitted (AUG-2024) to UniProtKB. CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single- CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}. CC -!- SIMILARITY: Belongs to the MHC class II family. CC {ECO:0000256|ARBA:ARBA00007394}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR AlphaFoldDB; A0A498U6I0; -. DR SMR; A0A498U6I0; -. DR Ensembl; ENSMUST00000074557.11; ENSMUSP00000074143.10; ENSMUSG00000060586.12. DR AGR; MGI:95901; -. DR MGI; MGI:95901; H2-Eb1. DR VEuPathDB; HostDB:ENSMUSG00000060586; -. DR GeneTree; ENSGT00940000155371; -. DR TreeFam; TF336626; -. DR ChiTaRS; H2-Eb1; mouse. DR Proteomes; UP000000589; Chromosome 17. DR Bgee; ENSMUSG00000060586; Expressed in mesenteric lymph node and 149 other cell types or tissues. DR ExpressionAtlas; A0A498U6I0; baseline and differential. DR GO; GO:0042613; C:MHC class II protein complex; IEA:UniProtKB-KW. DR GO; GO:0002250; P:adaptive immune response; IEA:UniProtKB-KW. DR GO; GO:0019886; P:antigen processing and presentation of exogenous peptide antigen via MHC class II; IEA:UniProt. DR FunFam; 2.60.40.10:FF:000116; HLA class II histocompatibility antigen, DRB1-1 beta chain; 1. DR FunFam; 3.10.320.10:FF:000001; HLA class II histocompatibility antigen, DRB1-1 beta chain; 1. DR Gene3D; 2.60.40.10; Immunoglobulins; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR050160; MHC/Immunoglobulin. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR014745; MHC_II_a/b_N. DR InterPro; IPR000353; MHC_II_b_N. DR PANTHER; PTHR19944:SF99; HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, DR BETA 3 CHAIN; 1. DR PANTHER; PTHR19944; MHC CLASS II-RELATED; 1. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00969; MHC_II_beta; 1. DR SMART; SM00407; IGc1; 1. DR SMART; SM00921; MHC_II_beta; 1. DR SUPFAM; SSF48726; Immunoglobulin; 1. DR SUPFAM; SSF54452; MHC antigen-recognition domain; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 1: Evidence at protein level; KW Adaptive immunity {ECO:0000256|ARBA:ARBA00023130}; KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180}; KW Immunity {ECO:0000256|ARBA:ARBA00022859}; KW Membrane {ECO:0000256|ARBA:ARBA00023136}; KW MHC II {ECO:0000256|ARBA:ARBA00023182}; KW Proteomics identification {ECO:0007829|PeptideAtlas:A0A498U6I0}; KW Reference proteome {ECO:0000313|Proteomes:UP000000589}; KW Transmembrane {ECO:0000256|ARBA:ARBA00022692}; KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}. FT DOMAIN 103..193 FT /note="Ig-like" FT /evidence="ECO:0000259|PROSITE:PS50835" FT NON_TER 1 FT /evidence="ECO:0000313|Ensembl:ENSMUSP00000074143.10" SQ SEQUENCE 287 AA; 33037 MW; F5036C3CDFFF5338 CRC64; PPVALVRDSR PWFLEYCKSE CHFYNGTQRV RLLERYFYNL EENLRFDSDV GEFRAVTELG RPDAENWNSQ PEFLEQKRAE VDTVCRHNYE ISDKFLVRRR VEPTVTVYPT KTQPLEHHNL LVCSVSDFYP GNIEVRWFRN GKEEKTGIVS TGLVRNGDWT FQTLVMLETV PQSGEVYTCQ VEHPSLTDPV TVEWRMLTAR SSRTRFFLGL KAPSLRGSGV EMGFGLKPSK PLASFLRSTI HICTEQDVEW SWGLRAGPAL PGSGAVHLLQ EPERTVWTSA NRTPELR //