ID A0A498U6I0_MOUSE Unreviewed; 287 AA. AC A0A498U6I0; DT 05-JUN-2019, integrated into UniProtKB/TrEMBL. DT 05-JUN-2019, sequence version 1. DT 07-APR-2021, entry version 12. DE SubName: Full=H-2 class II histocompatibility antigen, I-A beta chain {ECO:0000313|Ensembl:ENSMUSP00000074143}; DE Flags: Fragment; GN Name=H2-Eb1 {ECO:0000313|Ensembl:ENSMUSP00000074143, GN ECO:0000313|MGI:MGI:95901}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000074143, ECO:0000313|Proteomes:UP000000589}; RN [1] {ECO:0000313|Ensembl:ENSMUSP00000074143, ECO:0000313|Proteomes:UP000000589} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000074143, RC ECO:0000313|Proteomes:UP000000589}; RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112; RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S., RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., RA Eichler E.E., Ponting C.P.; RT "Lineage-specific biology revealed by a finished genome assembly of the RT mouse."; RL PLoS Biol. 7:E1000112-E1000112(2009). RN [2] {ECO:0000313|Ensembl:ENSMUSP00000074143} RP IDENTIFICATION. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000074143}; RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single- CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}. CC -!- SIMILARITY: Belongs to the MHC class II family. CC {ECO:0000256|ARBA:ARBA00007394}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CR974422; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR SMR; A0A498U6I0; -. DR Ensembl; ENSMUST00000074557; ENSMUSP00000074143; ENSMUSG00000060586. DR MGI; MGI:95901; H2-Eb1. DR GeneTree; ENSGT00940000155371; -. DR TreeFam; TF336626; -. DR ChiTaRS; H2-Eb1; mouse. DR Proteomes; UP000000589; Chromosome 17. DR ExpressionAtlas; A0A498U6I0; baseline and differential. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042613; C:MHC class II protein complex; IEA:UniProtKB-KW. DR GO; GO:0002250; P:adaptive immune response; IEA:UniProtKB-KW. DR GO; GO:0002504; P:antigen processing and presentation of peptide or polysaccharide antigen via MHC class II; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.10.320.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR014745; MHC_II_a/b_N. DR InterPro; IPR000353; MHC_II_b_N. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00969; MHC_II_beta; 1. DR SMART; SM00407; IGc1; 1. DR SMART; SM00921; MHC_II_beta; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 1: Evidence at protein level; KW Adaptive immunity {ECO:0000256|ARBA:ARBA00023130}; KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180}; KW Immunity {ECO:0000256|ARBA:ARBA00022859}; KW Membrane {ECO:0000256|ARBA:ARBA00023136}; KW MHC II {ECO:0000256|ARBA:ARBA00023182}; KW Proteomics identification {ECO:0007829|EPD:A0A498U6I0, KW ECO:0007829|MaxQB:A0A498U6I0}; KW Reference proteome {ECO:0000313|Proteomes:UP000000589}; KW Transmembrane {ECO:0000256|ARBA:ARBA00022692}; KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}. FT DOMAIN 103..193 FT /note="Ig-like" FT /evidence="ECO:0000259|PROSITE:PS50835" FT NON_TER 1 FT /evidence="ECO:0000313|Ensembl:ENSMUSP00000074143" SQ SEQUENCE 287 AA; 33037 MW; F5036C3CDFFF5338 CRC64; PPVALVRDSR PWFLEYCKSE CHFYNGTQRV RLLERYFYNL EENLRFDSDV GEFRAVTELG RPDAENWNSQ PEFLEQKRAE VDTVCRHNYE ISDKFLVRRR VEPTVTVYPT KTQPLEHHNL LVCSVSDFYP GNIEVRWFRN GKEEKTGIVS TGLVRNGDWT FQTLVMLETV PQSGEVYTCQ VEHPSLTDPV TVEWRMLTAR SSRTRFFLGL KAPSLRGSGV EMGFGLKPSK PLASFLRSTI HICTEQDVEW SWGLRAGPAL PGSGAVHLLQ EPERTVWTSA NRTPELR //