ID A0A493T008_ANAPP Unreviewed; 488 AA. AC A0A493T008; DT 05-JUN-2019, integrated into UniProtKB/TrEMBL. DT 05-JUN-2019, sequence version 1. DT 18-SEP-2019, entry version 4. DE RecName: Full=Aldehyde dehydrogenase {ECO:0000256|PIRNR:PIRNR036492}; OS Anas platyrhynchos platyrhynchos (Northern mallard). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Neognathae; Galloanserae; Anseriformes; Anatidae; OC Anatinae; Anas. OX NCBI_TaxID=8840 {ECO:0000313|Ensembl:ENSAPLP00000019234, ECO:0000313|Proteomes:UP000016666}; RN [1] {ECO:0000313|Ensembl:ENSAPLP00000019234, ECO:0000313|Proteomes:UP000016666} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Hou Z.-C., Zhou Z.-K., Zhu F., Hou S.-S.; RT "A new Pekin duck reference genome."; RL Submitted (OCT-2017) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSAPLP00000019234} RP IDENTIFICATION. RG Ensembl; RL Submitted (APR-2019) to UniProtKB. CC -!- SIMILARITY: Belongs to the aldehyde dehydrogenase family. CC {ECO:0000256|PIRNR:PIRNR036492, ECO:0000256|RuleBase:RU003345}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR Ensembl; ENSAPLT00000026106; ENSAPLP00000019234; ENSAPLG00000002714. DR GeneTree; ENSGT00940000157944; -. DR Proteomes; UP000016666; Chromosome 20. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0016620; F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor; IEA:InterPro. DR GO; GO:0006081; P:cellular aldehyde metabolic process; IEA:InterPro. DR Gene3D; 3.40.309.10; -; 1. DR Gene3D; 3.40.605.10; -; 1. DR InterPro; IPR016161; Ald_DH/histidinol_DH. DR InterPro; IPR016163; Ald_DH_C. DR InterPro; IPR016160; Ald_DH_CS_CYS. DR InterPro; IPR029510; Ald_DH_CS_GLU. DR InterPro; IPR016162; Ald_DH_N. DR InterPro; IPR015590; Aldehyde_DH_dom. DR InterPro; IPR012394; Aldehyde_DH_NAD(P). DR Pfam; PF00171; Aldedh; 1. DR PIRSF; PIRSF036492; ALDH; 1. DR SUPFAM; SSF53720; SSF53720; 1. DR PROSITE; PS00070; ALDEHYDE_DEHYDR_CYS; 1. DR PROSITE; PS00687; ALDEHYDE_DEHYDR_GLU; 1. PE 3: Inferred from homology; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Complete proteome {ECO:0000313|Proteomes:UP000016666}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Oxidoreductase {ECO:0000256|PIRNR:PIRNR036492, KW ECO:0000256|RuleBase:RU003345}; KW Reference proteome {ECO:0000313|Proteomes:UP000016666}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 465 487 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 3 425 Aldedh. {ECO:0000259|Pfam:PF00171}. FT COILED 23 50 {ECO:0000256|SAM:Coils}. FT ACT_SITE 210 210 {ECO:0000256|PIRSR:PIRSR036492-1, FT ECO:0000256|PROSITE-ProRule:PRU10007}. FT ACT_SITE 244 244 {ECO:0000256|PIRSR:PIRSR036492-1, FT ECO:0000256|PROSITE-ProRule:PRU10008}. SQ SEQUENCE 488 AA; 54249 MW; F0E9B29C0215E36D CRC64; MERMQQVVGR ARAAFSSGRC RSLEFRLQQL KNLERMVREK EKEILAALQS DLHKCGHNAY SHEVMGVLGE LAQAMENLPS WAAPQPVKKN LLTMRDEAYI YPEPLGVVLV IGAWNYPFML VVQPLIGAIA AGNAVVVKPS EVSEHTSQLL ADLLPQYLDE ELYPVVTGGV PETTELLKQR FDHILYTGNT AVGKIVMAAA AKHLTPVTLE LGGKSPCYID KDCDLAVACR RITWGKYMNC GQTCIAPDYI LCEPSIQSQV VENIKATLQE FYGEDVKKSP DYERIVNKRH FRRIVSLLEG QKIAHGGETD EASCFIAPTI LTDVSAESKV MEEEIFGPVL PIVSVKGVDE AIEFINSREK PLALYVFSND KKLIKRVISE TSSGGMTAND VLMHSTVLDL PFGGVGNSGM GAYHGKHSFE TFSHHRACLI KDLKMEGMNK LRYPPGSQKK LDWAKFFILK RFDKVRYGLI FLALLGVVAA VMIKVMFP //