ID A0A482KE01_HUMAN Unreviewed; 64 AA. AC A0A482KE01; DT 05-JUN-2019, integrated into UniProtKB/TrEMBL. DT 05-JUN-2019, sequence version 1. DT 07-APR-2021, entry version 10. DE RecName: Full=Methylenetetrahydrofolate reductase (NAD(P)H) {ECO:0000256|ARBA:ARBA00012871}; DE EC=1.5.1.20 {ECO:0000256|ARBA:ARBA00012871}; DE Flags: Fragment; GN Name=MTHFR {ECO:0000313|EMBL:QBQ03487.1}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606 {ECO:0000313|EMBL:QBQ03487.1}; RN [1] {ECO:0000313|EMBL:QBQ03487.1} RP NUCLEOTIDE SEQUENCE. RA Halder P.; RL Submitted (MAR-2019) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|EMBL:QBQ03487.1} RP NUCLEOTIDE SEQUENCE. RA Pal U., Ray A., Ghosh S.; RT "MTHFR gene polymorphism associated with Down syndrome birth risk in Indian RT population."; RL Submitted (APR-2019) to the EMBL/GenBank/DDBJ databases. CC -!- CATALYTIC ACTIVITY: CC Reaction=(6S)-5-methyl-5,6,7,8-tetrahydrofolate + NAD(+) = (6R)-5,10- CC methylene-5,6,7,8-tetrahydrofolate + H(+) + NADH; CC Xref=Rhea:RHEA:19821, ChEBI:CHEBI:15378, ChEBI:CHEBI:15636, CC ChEBI:CHEBI:18608, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.5.1.20; CC Evidence={ECO:0000256|ARBA:ARBA00001287}; CC -!- CATALYTIC ACTIVITY: CC Reaction=(6S)-5-methyl-5,6,7,8-tetrahydrofolate + NADP(+) = (6R)-5,10- CC methylene-5,6,7,8-tetrahydrofolate + H(+) + NADPH; CC Xref=Rhea:RHEA:19817, ChEBI:CHEBI:15378, ChEBI:CHEBI:15636, CC ChEBI:CHEBI:18608, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.5.1.20; CC Evidence={ECO:0000256|ARBA:ARBA00000431}; CC -!- COFACTOR: CC Name=FAD; Xref=ChEBI:CHEBI:57692; CC Evidence={ECO:0000256|ARBA:ARBA00001974}; CC -!- PATHWAY: One-carbon metabolism; tetrahydrofolate interconversion. CC {ECO:0000256|ARBA:ARBA00004777, ECO:0000256|RuleBase:RU004254}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; MK599407; QBQ03487.1; -; Genomic_DNA. DR PeptideAtlas; A0A482KE01; -. DR UniPathway; UPA00193; -. DR ChiTaRS; MTHFR; human. DR GO; GO:0106312; F:methylenetetrahydrofolate reductase NADH activity; IEA:RHEA. DR GO; GO:0106313; F:methylenetetrahydrofolate reductase NADPH activity; IEA:RHEA. DR GO; GO:0006555; P:methionine metabolic process; IEA:InterPro. DR GO; GO:0035999; P:tetrahydrofolate interconversion; IEA:UniProtKB-UniPathway. DR InterPro; IPR029041; FAD-linked_oxidoreductase-like. DR InterPro; IPR003171; Mehydrof_redctse-like. DR Pfam; PF02219; MTHFR; 1. DR SUPFAM; SSF51730; SSF51730; 1. PE 4: Predicted; KW FAD {ECO:0000256|ARBA:ARBA00022827}; KW Flavoprotein {ECO:0000256|ARBA:ARBA00022630}; KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002, KW ECO:0000313|EMBL:QBQ03487.1}. FT NON_TER 1 FT /evidence="ECO:0000313|EMBL:QBQ03487.1" FT NON_TER 64 FT /evidence="ECO:0000313|EMBL:QBQ03487.1" SQ SEQUENCE 64 AA; 7120 MW; 0391F919BBED3CCF CRC64; YPKGHPEAGS FEADLKHLKE KVSAGADFII TQLFFEVDTF FRFVKACTDM GITCPIVPGI FPIQ //