ID A0A481WBD3_HEV Unreviewed; 197 AA. AC A0A481WBD3; DT 05-JUN-2019, integrated into UniProtKB/TrEMBL. DT 05-JUN-2019, sequence version 1. DT 31-JUL-2019, entry version 3. DE RecName: Full=Protein ORF2 {ECO:0000256|RuleBase:RU363023}; DE Flags: Fragment; OS Hepatitis E virus (HEV). OC Viruses; Riboviria; Hepeviridae; Orthohepevirus; Orthohepevirus A. OX NCBI_TaxID=12461 {ECO:0000313|EMBL:QBJ06504.1}; OH NCBI_TaxID=9606; Homo sapiens (Human). RN [1] {ECO:0000313|EMBL:QBJ06504.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=P005-SG-1209 {ECO:0000313|EMBL:QBJ06504.1}; RX PubMed=28834649; DOI=.1111/liv.13557; RA Fraga M., Doerig C., Moulin H., Bihl F., Brunner F., Mullhaupt B., RA Ripellino P., Semela D., Stickel F., Terziroli Beretta-Piccoli B., RA Aubert V., Telenti A., Greub G., Sahli R., Moradpour D.; RT "Hepatitis E virus as a cause of acute hepatitis acquired in RT Switzerland."; RL Liver Int. 38:619-626(2018). RN [2] {ECO:0000313|EMBL:QBJ06504.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=P005-SG-1209 {ECO:0000313|EMBL:QBJ06504.1}; RX PubMed=30803864; RA Sahli R., Fraga M., Semela D., Moradpour D., Gouttenoire J.; RT "Rabbit HEV in immunosuppressed patients with hepatitis E acquired in RT Switzerland."; RL J. Hepatol. 70:1023-1025(2019). CC -!- FUNCTION: Major viral capsid protein that encapsidates the viral CC genome. Binds to the 5' end of the genomic RNA. CC {ECO:0000256|RuleBase:RU363023}. CC -!- SUBUNIT: Self-assembles to form the capsid. CC {ECO:0000256|RuleBase:RU363023}. CC -!- SUBCELLULAR LOCATION: Host cell surface CC {ECO:0000256|RuleBase:RU363023}. Host cytoplasm CC {ECO:0000256|RuleBase:RU363023}. Virion CC {ECO:0000256|RuleBase:RU363023}. CC -!- SIMILARITY: Belongs to the hepevirus capsid protein family. CC {ECO:0000256|RuleBase:RU363023}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; MK342959; QBJ06504.1; -; Genomic_RNA. DR GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell. DR GO; GO:0044228; C:host cell surface; IEA:UniProtKB-SubCell. DR GO; GO:0019028; C:viral capsid; IEA:UniProtKB-KW. DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW. DR Gene3D; 2.60.120.20; -; 1. DR InterPro; IPR004261; SP2. DR InterPro; IPR029053; Viral_coat. DR Pfam; PF03014; SP2; 1. PE 3: Inferred from homology; KW Capsid protein {ECO:0000256|RuleBase:RU363023}; KW Host cytoplasm {ECO:0000256|RuleBase:RU363023}; KW RNA-binding {ECO:0000256|RuleBase:RU363023}; KW Virion {ECO:0000256|RuleBase:RU363023}. FT NON_TER 1 1 {ECO:0000313|EMBL:QBJ06504.1}. FT NON_TER 197 197 {ECO:0000313|EMBL:QBJ06504.1}. SQ SEQUENCE 197 AA; 21285 MW; A1D4AA27D261A979 CRC64; VRATIRYRPL VPNAVGGYAI SISFWPQTTT TPTSVDMNSI TSTDVRILVQ PGIASELVIP SERLHYRNQG WRSVETSGVA EEEATSGLVM LCIHGSPVNS YTNTPYTGAL GLLDFALELE FRNLTPGNTN TRVSRYTSTA RHRLRRGADG TAELTTTAAT RFMKDLHFTG TNGVGEVGRG IALTLFNLAD TLLGGLP //