ID A0A481WBD3_HEV Unreviewed; 197 AA. AC A0A481WBD3; DT 05-JUN-2019, integrated into UniProtKB/TrEMBL. DT 05-JUN-2019, sequence version 1. DT 27-MAR-2024, entry version 17. DE SubName: Full=Capsid protein {ECO:0000313|EMBL:QBJ06504.1}; DE Flags: Fragment; OS Hepatitis E virus (HEV). OC Viruses; Riboviria; Orthornavirae; Kitrinoviricota; Alsuviricetes; OC Hepelivirales; Hepeviridae; Orthohepevirinae; Paslahepevirus. OX NCBI_TaxID=1678143 {ECO:0000313|EMBL:QBJ06504.1}; OH NCBI_TaxID=69079; Bandicota bengalensis (lesser bandicoot rat). OH NCBI_TaxID=9481; Callithrix. OH NCBI_TaxID=9536; Cercopithecus hamlyni (Owl-faced monkey) (Hamlyn's monkey). OH NCBI_TaxID=9534; Chlorocebus aethiops (Green monkey) (Cercopithecus aethiops). OH NCBI_TaxID=9031; Gallus gallus (Chicken). OH NCBI_TaxID=9606; Homo sapiens (Human). OH NCBI_TaxID=9539; Macaca (macaques). OH NCBI_TaxID=10090; Mus musculus (Mouse). OH NCBI_TaxID=9598; Pan troglodytes (Chimpanzee). OH NCBI_TaxID=9520; Saimiri (squirrel monkeys). OH NCBI_TaxID=9823; Sus scrofa (Pig). RN [1] {ECO:0000313|EMBL:QBJ06504.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=P005-SG-1209 {ECO:0000313|EMBL:QBJ06504.1}; RX PubMed=28834649; DOI=.1111/liv.13557; RA Fraga M., Doerig C., Moulin H., Bihl F., Brunner F., Mullhaupt B., RA Ripellino P., Semela D., Stickel F., Terziroli Beretta-Piccoli B., RA Aubert V., Telenti A., Greub G., Sahli R., Moradpour D.; RT "Hepatitis E virus as a cause of acute hepatitis acquired in Switzerland."; RL Liver Int. 38:619-626(2018). RN [2] {ECO:0000313|EMBL:QBJ06504.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=P005-SG-1209 {ECO:0000313|EMBL:QBJ06504.1}; RX PubMed=30803864; RA Sahli R., Fraga M., Semela D., Moradpour D., Gouttenoire J.; RT "Rabbit HEV in immunosuppressed patients with hepatitis E acquired in RT Switzerland."; RL J. Hepatol. 70:1023-1025(2019). CC -!- SUBCELLULAR LOCATION: Cell surface {ECO:0000256|ARBA:ARBA00004241}. CC Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00004240}. Host Golgi CC apparatus {ECO:0000256|ARBA:ARBA00004136}. Host cell surface CC {ECO:0000256|ARBA:ARBA00004426}. Host endoplasmic reticulum CC {ECO:0000256|ARBA:ARBA00004354}. Virion CC {ECO:0000256|ARBA:ARBA00004328}. CC -!- SIMILARITY: Belongs to the hepevirus capsid protein family. CC {ECO:0000256|ARBA:ARBA00008877}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; MK342959; QBJ06504.1; -; Genomic_RNA. DR GO; GO:0044165; C:host cell endoplasmic reticulum; IEA:UniProtKB-SubCell. DR GO; GO:0044177; C:host cell Golgi apparatus; IEA:UniProtKB-SubCell. DR GO; GO:0044228; C:host cell surface; IEA:UniProtKB-SubCell. DR GO; GO:0019028; C:viral capsid; IEA:UniProtKB-KW. DR GO; GO:0003723; F:RNA binding; IEA:InterPro. DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro. DR Gene3D; 2.40.30.190; -; 1. DR Gene3D; 2.60.120.20; -; 1. DR InterPro; IPR048802; SP2_M. DR InterPro; IPR004261; SP2_N. DR InterPro; IPR029053; Viral_coat. DR Pfam; PF03014; SP2; 1. DR Pfam; PF20751; SP2_M; 1. PE 3: Inferred from homology; KW Capsid protein {ECO:0000256|ARBA:ARBA00022561}; KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180}; KW Host endoplasmic reticulum {ECO:0000256|ARBA:ARBA00023184}; KW Host Golgi apparatus {ECO:0000256|ARBA:ARBA00022812}; KW Virion {ECO:0000256|ARBA:ARBA00022844}. FT DOMAIN 2..124 FT /note="Hepatitis E virus structural protein 2 N-terminal" FT /evidence="ECO:0000259|Pfam:PF03014" FT DOMAIN 127..197 FT /note="Structural protein 2 second" FT /evidence="ECO:0000259|Pfam:PF20751" FT NON_TER 1 FT /evidence="ECO:0000313|EMBL:QBJ06504.1" FT NON_TER 197 FT /evidence="ECO:0000313|EMBL:QBJ06504.1" SQ SEQUENCE 197 AA; 21285 MW; A1D4AA27D261A979 CRC64; VRATIRYRPL VPNAVGGYAI SISFWPQTTT TPTSVDMNSI TSTDVRILVQ PGIASELVIP SERLHYRNQG WRSVETSGVA EEEATSGLVM LCIHGSPVNS YTNTPYTGAL GLLDFALELE FRNLTPGNTN TRVSRYTSTA RHRLRRGADG TAELTTTAAT RFMKDLHFTG TNGVGEVGRG IALTLFNLAD TLLGGLP //