ID   A0A452U4K9_URSMA        Unreviewed;       356 AA.
AC   A0A452U4K9;
DT   08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT   08-MAY-2019, sequence version 1.
DT   08-NOV-2023, entry version 22.
DE   RecName: Full=Beta-nerve growth factor {ECO:0000256|ARBA:ARBA00019522};
GN   Name=NGF {ECO:0000313|Ensembl:ENSUMAP00000015649};
OS   Ursus maritimus (Polar bear) (Thalarctos maritimus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX   NCBI_TaxID=29073 {ECO:0000313|Ensembl:ENSUMAP00000015649};
RN   [1] {ECO:0000313|Ensembl:ENSUMAP00000015649}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (MAR-2019) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC   -!- SIMILARITY: Belongs to the NGF-beta family.
CC       {ECO:0000256|ARBA:ARBA00010783}.
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DR   Ensembl; ENSUMAT00000018527.1; ENSUMAP00000015649.1; ENSUMAG00000011483.1.
DR   OMA; GRQRECE; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005102; F:signaling receptor binding; IEA:InterPro.
DR   Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR   InterPro; IPR029034; Cystine-knot_cytokine.
DR   InterPro; IPR020408; Nerve_growth_factor-like.
DR   InterPro; IPR002072; Nerve_growth_factor-rel.
DR   InterPro; IPR020425; Nerve_growth_factor_bsu.
DR   InterPro; IPR020437; Nerve_growth_factor_bsu_mml.
DR   InterPro; IPR019846; Nerve_growth_factor_CS.
DR   PANTHER; PTHR11589:SF10; BETA-NERVE GROWTH FACTOR; 1.
DR   PANTHER; PTHR11589; NERVE GROWTH FACTOR NGF -RELATED; 1.
DR   Pfam; PF00243; NGF; 1.
DR   PRINTS; PR01925; MAMLNGFBETA.
DR   PRINTS; PR00268; NGF.
DR   PRINTS; PR01913; NGFBETA.
DR   SMART; SM00140; NGF; 1.
DR   SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR   PROSITE; PS00248; NGF_1; 1.
DR   PROSITE; PS50270; NGF_2; 1.
PE   3: Inferred from homology;
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Secreted {ECO:0000256|ARBA:ARBA00022525};
KW   Signal {ECO:0000256|ARBA:ARBA00022729}.
FT   DOMAIN          216..305
FT                   /note="Nerve growth factor-related"
FT                   /evidence="ECO:0000259|SMART:SM00140"
FT   REGION          320..351
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        333..349
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   356 AA;  38791 MW;  2A7C92F71D96F969 CRC64;
     MYEMVFYCMS MNGNINRLHL APSAPGLVFT PKKPTGRESH PSPEVLARGR AVQGAGWHAA
     PKLSSASGPN NGFSKGAAFC PGHTEVHSVM SMLFHTLITA LLIGIQAEPH PESHVPAGHA
     IPQAHWTKLQ HSLDTALRRA RSAPAGAIAA RVAGQTRNIT VDPKLFKKRR LRSPRVLFST
     HPPPVATDTQ DLDLEAGSAS VNRTHRSKRS SSHPVFHRGE FSVCDSVSVW VGDKTTATDI
     KGKEVMVLGE VNINNSVFKQ YFFETKCRDP TPVDSGCRGI DSKHWNSYCT TTHTFVXXXX
     XXXXXXXXXX XXXXXXXXXX XXXXXXXPDL QDGPHPPRAP PPHPPGPLPT STCKLF
//