ID A0A452R2A2_URSAM Unreviewed; 772 AA. AC A0A452R2A2; DT 08-MAY-2019, integrated into UniProtKB/TrEMBL. DT 08-MAY-2019, sequence version 1. DT 29-MAY-2024, entry version 23. DE SubName: Full=Leucine rich repeat and fibronectin type III domain containing 1 {ECO:0000313|Ensembl:ENSUAMP00000012316.1}; GN Name=LRFN1 {ECO:0000313|Ensembl:ENSUAMP00000012316.1}; OS Ursus americanus (American black bear) (Euarctos americanus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus. OX NCBI_TaxID=9643 {ECO:0000313|Ensembl:ENSUAMP00000012316.1, ECO:0000313|Proteomes:UP000291022}; RN [1] {ECO:0000313|Proteomes:UP000291022} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Korstanje R., Srivastava A., Sarsani V.K., Sheehan S.M., Seger R.L., RA Barter M.E., Lindqvist C., Brody L.C., Mullikin J.C.; RT "De novo assembly and RNA-Seq shows season-dependent expression and editing RT in black bear kidneys."; RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSUAMP00000012316.1} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2023) to UniProtKB. CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single- CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}. Synapse CC {ECO:0000256|ARBA:ARBA00034103}. CC -!- SIMILARITY: Belongs to the LRFN family. CC {ECO:0000256|ARBA:ARBA00038433}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR AlphaFoldDB; A0A452R2A2; -. DR STRING; 9643.ENSUAMP00000012316; -. DR Ensembl; ENSUAMT00000013841.1; ENSUAMP00000012316.1; ENSUAMG00000009991.1. DR GeneTree; ENSGT00940000160922; -. DR OMA; APVEVCI; -. DR Proteomes; UP000291022; Unassembled WGS sequence. DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell. DR GO; GO:0045202; C:synapse; IEA:UniProtKB-SubCell. DR CDD; cd00063; FN3; 1. DR Gene3D; 2.60.40.10; Immunoglobulins; 2. DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2. DR InterPro; IPR000483; Cys-rich_flank_reg_C. DR InterPro; IPR003961; FN3_dom. DR InterPro; IPR036116; FN3_sf. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR013098; Ig_I-set. DR InterPro; IPR003599; Ig_sub. DR InterPro; IPR003598; Ig_sub2. DR InterPro; IPR001611; Leu-rich_rpt. DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp. DR InterPro; IPR032675; LRR_dom_sf. DR PANTHER; PTHR45842:SF7; LEUCINE-RICH REPEAT AND FIBRONECTIN TYPE III DOMAIN-CONTAINING PROTEIN 1; 1. DR PANTHER; PTHR45842; SYNAPTIC ADHESION-LIKE MOLECULE SALM; 1. DR Pfam; PF00041; fn3; 1. DR Pfam; PF07679; I-set; 1. DR Pfam; PF13855; LRR_8; 2. DR SMART; SM00409; IG; 1. DR SMART; SM00408; IGc2; 1. DR SMART; SM00369; LRR_TYP; 6. DR SMART; SM00082; LRRCT; 1. DR SUPFAM; SSF49265; Fibronectin type III; 1. DR SUPFAM; SSF48726; Immunoglobulin; 1. DR SUPFAM; SSF52058; L domain-like; 1. DR PROSITE; PS50853; FN3; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS51450; LRR; 1. PE 3: Inferred from homology; KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157}; KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319}; KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000291022}; KW Repeat {ECO:0000256|ARBA:ARBA00022737}; KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1..31 FT /evidence="ECO:0000256|SAM:SignalP" FT CHAIN 32..772 FT /evidence="ECO:0000256|SAM:SignalP" FT /id="PRO_5019272170" FT TRANSMEM 531..559 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT DOMAIN 299..386 FT /note="Ig-like" FT /evidence="ECO:0000259|PROSITE:PS50835" FT DOMAIN 424..520 FT /note="Fibronectin type-III" FT /evidence="ECO:0000259|PROSITE:PS50853" FT REGION 397..424 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 568..602 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 657..684 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 718..748 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 772 AA; 82180 MW; 3E8B1BC3C5B38067 CRC64; MAPGPFSSAL LSPSPAALPF LLLLWAGASR GQPCPGRCIC QNVAPTLTML CAKTGLLFVP PAIDRRVVEL RLTDNFIAAV RRRDFANMTS LVHLTLSRNT IGQVAAGAFA DLRALRALHL DSNRLAEVRG DQLRGLGNLR HLILGNNQIR RVESAAFDAF LSTVEDLDLS YNNLEALPWE AVGQMVNLNT LTLDHNLIDH IAEGTFVQLH KLVRLDMTSN RLHKLPPDGL FLRSQGSGPK PPTPLTVSFG GNPLHCNCEL LWLRRLTRED DLETCATPEH LTDRYFWSIP EEEFLCEPPL ITRQAGGRAL VVEGQAVSLR CRAVGDPEPV VHWVAPDGRL LGNSTRTRVR GDGTLDVTIT TLRDSGTFTC IASNAAGEAT APVEVCVVPL PLMAPPPAAP PPLTEPGSSD IATPGRPGAN ESAAERRLVA AELTSNSVLI RWPAQRPVPG IRMYQVQYNS SADDSLVYRM IPSTSQTFLV NDLAAGRAYD LCVLAVYDDG ATALPATRVV GCVQFTTAGD PAPCRPLRAH FLGGTMIIAI GGVIVASVLV FIVLLMIRYK VYGDGDGRRV KGTSRSPPRV SHVCSQTNGA GAPQAPPPPA QDRYEALREV ASPAAAAAAV AVEAKATAAE TASAEPETVL GRSLGGSATS LCLLPSEETS GEESWAAAGP RRSRSGALGP PASAPPTLAL VPGAAPARPR PQQRYSFDGD YGALFQSHSY PRRARRTKRH RSTPHLDGAG GGAAGEDGDL GLGSARARLA FTSTEWMLES TV //