ID   A0A411GXB1_9AVES        Unreviewed;       325 AA.
AC   A0A411GXB1;
DT   08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT   08-MAY-2019, sequence version 1.
DT   24-JAN-2024, entry version 18.
DE   RecName: Full=NADH-ubiquinone oxidoreductase chain 1 {ECO:0000256|ARBA:ARBA00021009, ECO:0000256|RuleBase:RU000473};
DE            EC=7.1.1.2 {ECO:0000256|ARBA:ARBA00012944, ECO:0000256|RuleBase:RU000473};
GN   Name=ND1 {ECO:0000313|EMBL:QBB10640.1};
OS   Megadyptes waitaha (Waitaha penguin).
OG   Mitochondrion {ECO:0000313|EMBL:QBB10640.1}.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Sphenisciformes; Spheniscidae; Megadyptes.
OX   NCBI_TaxID=577682 {ECO:0000313|EMBL:QBB10640.1};
RN   [1] {ECO:0000313|EMBL:QBB10640.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Cole T.L., Ksepka D.T., Mitchell K.J., Tennyson A.J.D., Thomas D.B.,
RA   Pan H., Zhang G., Rawlence N.J., Wood J.R., Bover P., Bouzat J.L.,
RA   Cooper A., Fiddaman S., Hart T., Miller G., Ryan P.G., Shepherd L.D.,
RA   Wilmshurst J.M., Waters J.M.;
RT   "Mitogenomes uncover extinct penguin taxa and reveal island formation as a
RT   key driver of speciation.";
RL   Mol. Biol. Evol. 0:0-0(2019).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC         NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC         COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC         ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC         Evidence={ECO:0000256|ARBA:ARBA00000766,
CC         ECO:0000256|RuleBase:RU000473};
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. Mitochondrion
CC       inner membrane {ECO:0000256|RuleBase:RU000471}; Multi-pass membrane
CC       protein {ECO:0000256|RuleBase:RU000471}.
CC   -!- SIMILARITY: Belongs to the complex I subunit 1 family.
CC       {ECO:0000256|ARBA:ARBA00010535, ECO:0000256|RuleBase:RU000471}.
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DR   EMBL; MK290257; QBB10640.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A411GXB1; -.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR   GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC.
DR   HAMAP; MF_01350; NDH1_NuoH; 1.
DR   InterPro; IPR001694; NADH_UbQ_OxRdtase_su1/FPO.
DR   InterPro; IPR018086; NADH_UbQ_OxRdtase_su1_CS.
DR   PANTHER; PTHR11432; NADH DEHYDROGENASE SUBUNIT 1; 1.
DR   PANTHER; PTHR11432:SF3; NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 1; 1.
DR   Pfam; PF00146; NADHdh; 1.
DR   PROSITE; PS00667; COMPLEX1_ND1_1; 1.
DR   PROSITE; PS00668; COMPLEX1_ND1_2; 1.
PE   3: Inferred from homology;
KW   Electron transport {ECO:0000256|ARBA:ARBA00022982};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Mitochondrion {ECO:0000256|RuleBase:RU000473, ECO:0000313|EMBL:QBB10640.1};
KW   NAD {ECO:0000256|RuleBase:RU000471};
KW   Respiratory chain {ECO:0000256|ARBA:ARBA00022660};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU000471};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022660};
KW   Ubiquinone {ECO:0000256|RuleBase:RU000473}.
FT   TRANSMEM        6..29
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        76..96
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        108..128
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        149..167
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        179..198
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        227..249
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        261..280
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        300..321
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
SQ   SEQUENCE   325 AA;  36178 MW;  D6F505641DCECFF9 CRC64;
     MIWYPILTHL TMSLSYAIPI LIAVAYLTLV ERKILSYMQA RKGPNIVGPF GLLQPVADGV
     KLFIKEPIRP STSSPLLFIT TPVLALLLAI TIWIPLPLPF PLTDLNLGLL FLLAMSSLAV
     YSILWSGWAS NSKYALIGAL RAVAQTISYE VTLAIILLSI IVLSGNYTLT TLTTAQEPLY
     LIFSSWPLAM MWYISTLAET NRAPFDLTEG ESELVSGFNV EYAAGPFALF FLAEYANIML
     MNTLTTILFL NPSSLNPSPE LFPMILATKV LLLSSGFLWI RASYPRFRYD QLMHLLWKNF
     LPLTLALCLW HTSMPICYAG LPPCS
//