ID   A0A410CPM9_MACNP        Unreviewed;       652 AA.
AC   A0A410CPM9;
DT   08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT   08-MAY-2019, sequence version 1.
DT   02-OCT-2024, entry version 14.
DE   RecName: Full=Long-chain-fatty-acid--CoA ligase {ECO:0000256|ARBA:ARBA00041297};
OS   Macrobrachium nipponense (Oriental river shrimp) (Palaemon nipponensis).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Crustacea; Multicrustacea;
OC   Malacostraca; Eumalacostraca; Eucarida; Decapoda; Pleocyemata; Caridea;
OC   Palaemonoidea; Palaemonidae; Macrobrachium.
OX   NCBI_TaxID=159736 {ECO:0000313|EMBL:QAA06940.1};
RN   [1] {ECO:0000313|EMBL:QAA06940.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Ding Z.;
RT   "Dietary carbohydrate/lipid ratios affect growth, oxidative status and mRNA
RT   expression of lipid metabolism and immuno-related genes in juvenile
RT   oriental river prawn, Macrobrachium nipponense.";
RL   Submitted (APR-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + CoA + tetracosanoate = AMP + diphosphate +
CC         tetracosanoyl-CoA; Xref=Rhea:RHEA:33639, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:31014, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287,
CC         ChEBI:CHEBI:65052, ChEBI:CHEBI:456215;
CC         Evidence={ECO:0000256|ARBA:ARBA00036436};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:33640;
CC         Evidence={ECO:0000256|ARBA:ARBA00036436};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a very long-chain fatty acid + ATP + CoA = a very long-chain
CC         fatty acyl-CoA + AMP + diphosphate; Xref=Rhea:RHEA:54536,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287,
CC         ChEBI:CHEBI:58950, ChEBI:CHEBI:138261, ChEBI:CHEBI:456215;
CC         Evidence={ECO:0000256|ARBA:ARBA00036527};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:54537;
CC         Evidence={ECO:0000256|ARBA:ARBA00036527};
CC   -!- SIMILARITY: Belongs to the ATP-dependent AMP-binding enzyme family.
CC       {ECO:0000256|ARBA:ARBA00006432}.
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DR   EMBL; MH243322; QAA06940.1; -; mRNA.
DR   AlphaFoldDB; A0A410CPM9; -.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:TreeGrafter.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005324; F:long-chain fatty acid transmembrane transporter activity; IEA:TreeGrafter.
DR   GO; GO:0004467; F:long-chain fatty acid-CoA ligase activity; IEA:TreeGrafter.
DR   GO; GO:0070328; P:triglyceride homeostasis; IEA:TreeGrafter.
DR   Gene3D; 3.30.300.30; -; 1.
DR   Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR   InterPro; IPR045851; AMP-bd_C_sf.
DR   InterPro; IPR020845; AMP-binding_CS.
DR   InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR   InterPro; IPR042099; ANL_N_sf.
DR   PANTHER; PTHR43107:SF15; FATTY ACID TRANSPORT PROTEIN 3, ISOFORM A; 1.
DR   PANTHER; PTHR43107; LONG-CHAIN FATTY ACID TRANSPORT PROTEIN; 1.
DR   Pfam; PF00501; AMP-binding; 1.
DR   SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR   PROSITE; PS00455; AMP_BINDING; 1.
PE   2: Evidence at transcript level;
KW   Ligase {ECO:0000256|ARBA:ARBA00022598}; Membrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        37..58
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          94..455
FT                   /note="AMP-dependent synthetase/ligase"
FT                   /evidence="ECO:0000259|Pfam:PF00501"
SQ   SEQUENCE   652 AA;  72276 MW;  B4F0D742D91276F9 CRC64;
     MLKTAAIVGV TSALWAAGQH GLSLCGFLIP KLSGLHLAVL AAGVYLTTGG VHTLWLVYHT
     LPRDLKAGIR FLKVKAKLKL ALFHNLTVPK VFMENVRKNP NKVAFIYEGQ EWTFTQVDEY
     SNRIGNFMIE QGFKHGDSIA LYMYNRPEYV CTWLGCAKVG IVPALINFNL QNVSLVHSIK
     VADCKAVICG IELQASIKEV LEELNLPVFI SGCGNTAPVI KGTTNLDPLL CASNPTPPHQ
     IDSVKPNDRL IYIYTSGTTG LPKAAVIKHI RFMFFVTATH YMLGLSEDEI IYNPLPLYHT
     AGGMVGIGQV LLFNNTAVIR QKFSVSQYWV EAKKYGCTVG QYVGEICRYL LSAPPKPEDT
     QHKVRVMFGN GVRQQIWEQF TSRFNMPRIA EFYGATEGIA NIVNLEGKPG SCGFLSLLFP
     DAVRCYLIKV DEETGEPVRD ANGLCIKCKP GEPGEFVGII KRSDPLRDFQ GYADKKATQK
     KLVENVLRKG DIAFKSGDIL VQDEFGYMYF KDRTGDTFRW RGENVSSTEV EGIVSKIADH
     KDAVVYGVEV PGCEGRAGMA AIVDPNNELD IKEFSEGIKK PLPVYARPLF LRLISEIDVT
     GTFKLKKLAL QKEGFNPSLV RGNLYYLDNK LGQYVELTPE LYSQIEGGKA GL
//