ID A0A3S2UJT0_9GAMM Unreviewed; 188 AA. AC A0A3S2UJT0; DT 10-APR-2019, integrated into UniProtKB/TrEMBL. DT 10-APR-2019, sequence version 1. DT 22-FEB-2023, entry version 12. DE RecName: Full=dTDP-4-dehydrorhamnose 3,5-epimerase {ECO:0000256|ARBA:ARBA00019595, ECO:0000256|RuleBase:RU364069}; DE EC=5.1.3.13 {ECO:0000256|ARBA:ARBA00012098, ECO:0000256|RuleBase:RU364069}; DE AltName: Full=Thymidine diphospho-4-keto-rhamnose 3,5-epimerase {ECO:0000256|RuleBase:RU364069}; GN Name=rfbC {ECO:0000313|EMBL:RVT46901.1}; GN ORFNames=EMM73_06870 {ECO:0000313|EMBL:RVT46901.1}; OS Rheinheimera sp. YQF-1. OC Bacteria; Proteobacteria; Gammaproteobacteria; Chromatiales; Chromatiaceae; OC Rheinheimera. OX NCBI_TaxID=2499626 {ECO:0000313|EMBL:RVT46901.1, ECO:0000313|Proteomes:UP000286988}; RN [1] {ECO:0000313|EMBL:RVT46901.1, ECO:0000313|Proteomes:UP000286988} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=yqf_1 {ECO:0000313|Proteomes:UP000286988}; RA Yu Q., Qi Y., Pu J.; RT "Draft genome analysis of Rheinheimera sp. isolated from a coastal RT wetland."; RL Submitted (JAN-2019) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Catalyzes the epimerization of the C3' and C5'positions of CC dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose. CC {ECO:0000256|ARBA:ARBA00001997, ECO:0000256|RuleBase:RU364069}. CC -!- CATALYTIC ACTIVITY: CC Reaction=dTDP-4-dehydro-6-deoxy-alpha-D-glucose = dTDP-4-dehydro-beta- CC L-rhamnose; Xref=Rhea:RHEA:16969, ChEBI:CHEBI:57649, CC ChEBI:CHEBI:62830; EC=5.1.3.13; CC Evidence={ECO:0000256|ARBA:ARBA00001298, CC ECO:0000256|RuleBase:RU364069}; CC -!- PATHWAY: Carbohydrate biosynthesis; dTDP-L-rhamnose biosynthesis. CC {ECO:0000256|RuleBase:RU364069}. CC -!- SUBUNIT: Homodimer. {ECO:0000256|RuleBase:RU364069}. CC -!- SIMILARITY: Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family. CC {ECO:0000256|RuleBase:RU364069}. CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ CC whole genome shotgun (WGS) entry which is preliminary data. CC {ECO:0000313|EMBL:RVT46901.1}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; RZUF01000008; RVT46901.1; -; Genomic_DNA. DR AlphaFoldDB; A0A3S2UJT0; -. DR EnsemblBacteria; RVT46901; RVT46901; EMM73_06870. DR OrthoDB; 9800680at2; -. DR UniPathway; UPA00124; -. DR Proteomes; UP000286988; Unassembled WGS sequence. DR GO; GO:0008830; F:dTDP-4-dehydrorhamnose 3,5-epimerase activity; IEA:UniProtKB-UniRule. DR GO; GO:0019305; P:dTDP-rhamnose biosynthetic process; IEA:UniProtKB-UniRule. DR CDD; cd00438; cupin_RmlC; 1. DR Gene3D; 2.60.120.10; Jelly Rolls; 1. DR InterPro; IPR000888; dTDP_sugar_isom. DR InterPro; IPR014710; RmlC-like_jellyroll. DR InterPro; IPR011051; RmlC_Cupin_sf. DR PANTHER; PTHR21047; DTDP-6-DEOXY-D-GLUCOSE-3,5 EPIMERASE; 1. DR PANTHER; PTHR21047:SF2; L-RHAMNOSE BIOSYNTHETIC PATHWAY; 1. DR Pfam; PF00908; dTDP_sugar_isom; 1. DR SUPFAM; SSF51182; RmlC-like cupins; 1. DR TIGRFAMs; TIGR01221; rmlC; 1. PE 3: Inferred from homology; KW Isomerase {ECO:0000256|RuleBase:RU364069, ECO:0000313|EMBL:RVT46901.1}. FT ACT_SITE 62 FT /note="Proton acceptor" FT /evidence="ECO:0000256|PIRSR:PIRSR600888-1" FT ACT_SITE 131 FT /note="Proton donor" FT /evidence="ECO:0000256|PIRSR:PIRSR600888-1" FT SITE 137 FT /note="Participates in a stacking interaction with the FT thymidine ring of dTDP-4-oxo-6-deoxyglucose" FT /evidence="ECO:0000256|PIRSR:PIRSR600888-3" SQ SEQUENCE 188 AA; 21334 MW; 2375E12E07F02E35 CRC64; MVQITALPLP GLLLLQPKVY EDERGYFFEV NRSAELEQIL GHIDFVQESQ SGSVHHVLRG LHYQLERPQA KLIRVLSGQI FDVVVDLRLQ SASFGQWYGL ELCAEKRHQL FIPAGFAHGF LTLSQYAEVA YKTDQYYDPS SERAIKWDDR QLAINWPLQK PPLVSAKDAA AQSFASADVY PTMGLEQI //