ID   A0A3S2P2X3_ORYJA        Unreviewed;      1015 AA.
AC   A0A3S2P2X3;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   07-APR-2021, entry version 11.
DE   RecName: Full=Poly [ADP-ribose] polymerase {ECO:0000256|PIRNR:PIRNR000489, ECO:0000256|RuleBase:RU362114};
DE            EC=2.4.2.30 {ECO:0000256|PIRNR:PIRNR000489};
GN   ORFNames=OJAV_G00229600 {ECO:0000313|EMBL:RVE55796.1};
OS   Oryzias javanicus (Javanese ricefish) (Aplocheilus javanicus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC   Oryzias.
OX   NCBI_TaxID=123683 {ECO:0000313|EMBL:RVE55796.1, ECO:0000313|Proteomes:UP000283210};
RN   [1] {ECO:0000313|EMBL:RVE55796.1, ECO:0000313|Proteomes:UP000283210}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RS831 {ECO:0000313|EMBL:RVE55796.1};
RC   TISSUE=Whole body {ECO:0000313|EMBL:RVE55796.1};
RA   Lopez-Roques C., Donnadieu C., Bouchez O., Klopp C., Cabau C., Zahm M.;
RL   Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:RVE55796.1, ECO:0000313|Proteomes:UP000283210}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RS831 {ECO:0000313|EMBL:RVE55796.1};
RC   TISSUE=Whole body {ECO:0000313|EMBL:RVE55796.1};
RA   Herpin A., Takehana Y., Naruse K., Ansai S., Kawaguchi M.;
RT   "A chromosome length genome reference of the Java medaka (oryzias
RT   javanicus).";
RL   Submitted (JAN-2019) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Poly-ADP-ribosyltransferase that mediates poly-ADP-
CC       ribosylation of proteins and plays a key role in DNA repair.
CC       {ECO:0000256|PIRNR:PIRNR000489}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=L-aspartyl-[protein] + NAD(+) = 4-O-(ADP-D-ribosyl)-L-
CC         aspartyl-[protein] + nicotinamide; Xref=Rhea:RHEA:54424, Rhea:RHEA-
CC         COMP:9867, Rhea:RHEA-COMP:13832, ChEBI:CHEBI:17154,
CC         ChEBI:CHEBI:29961, ChEBI:CHEBI:57540, ChEBI:CHEBI:138102;
CC         Evidence={ECO:0000256|PIRNR:PIRNR000489};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=L-glutamyl-[protein] + NAD(+) = 5-O-(ADP-D-ribosyl)-L-
CC         glutamyl-[protein] + nicotinamide; Xref=Rhea:RHEA:58224, Rhea:RHEA-
CC         COMP:10208, Rhea:RHEA-COMP:15089, ChEBI:CHEBI:17154,
CC         ChEBI:CHEBI:29973, ChEBI:CHEBI:57540, ChEBI:CHEBI:142540;
CC         Evidence={ECO:0000256|PIRNR:PIRNR000489};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=NAD(+) + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-
CC         ribosyl)(n+1)-acceptor.; EC=2.4.2.30;
CC         Evidence={ECO:0000256|ARBA:ARBA00001645,
CC         ECO:0000256|PIRNR:PIRNR000489};
CC   -!- SUBCELLULAR LOCATION: Chromosome {ECO:0000256|PIRNR:PIRNR000489}.
CC       Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PIRNR:PIRNR000489}.
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DR   EMBL; CM012460; RVE55796.1; -; Genomic_DNA.
DR   Ensembl; ENSOJAT00000036795; ENSOJAP00000034543; ENSOJAG00000017082.
DR   Proteomes; UP000283210; Chromosome 24.
DR   GO; GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0051287; F:NAD binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003950; F:NAD+ ADP-ribosyltransferase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0006471; P:protein ADP-ribosylation; IEA:InterPro.
DR   Gene3D; 1.20.142.10; -; 1.
DR   Gene3D; 2.20.140.10; -; 1.
DR   Gene3D; 2.20.25.630; -; 1.
DR   Gene3D; 3.30.1740.10; -; 2.
DR   Gene3D; 3.40.50.10190; -; 1.
DR   InterPro; IPR001357; BRCT_dom.
DR   InterPro; IPR036420; BRCT_dom_sf.
DR   InterPro; IPR012982; PADR1.
DR   InterPro; IPR038650; PADR1_dom_sf.
DR   InterPro; IPR008288; PARP.
DR   InterPro; IPR012317; Poly(ADP-ribose)pol_cat_dom.
DR   InterPro; IPR004102; Poly(ADP-ribose)pol_reg_dom.
DR   InterPro; IPR036616; Poly(ADP-ribose)pol_reg_dom_sf.
DR   InterPro; IPR036930; WGR_dom_sf.
DR   InterPro; IPR008893; WGR_domain.
DR   InterPro; IPR001510; Znf_PARP.
DR   InterPro; IPR036957; Znf_PARP_sf.
DR   Pfam; PF00533; BRCT; 1.
DR   Pfam; PF08063; PADR1; 1.
DR   Pfam; PF00644; PARP; 1.
DR   Pfam; PF02877; PARP_reg; 1.
DR   Pfam; PF05406; WGR; 1.
DR   Pfam; PF00645; zf-PARP; 2.
DR   PIRSF; PIRSF000489; NAD_ADPRT; 1.
DR   SMART; SM00292; BRCT; 1.
DR   SMART; SM01335; PADR1; 1.
DR   SMART; SM00773; WGR; 1.
DR   SMART; SM01336; zf-PARP; 2.
DR   SUPFAM; SSF142921; SSF142921; 1.
DR   SUPFAM; SSF47587; SSF47587; 1.
DR   SUPFAM; SSF52113; SSF52113; 1.
DR   PROSITE; PS50172; BRCT; 1.
DR   PROSITE; PS51060; PARP_ALPHA_HD; 1.
DR   PROSITE; PS51059; PARP_CATALYTIC; 1.
DR   PROSITE; PS00347; PARP_ZN_FINGER_1; 1.
DR   PROSITE; PS50064; PARP_ZN_FINGER_2; 2.
PE   4: Predicted;
KW   ADP-ribosylation {ECO:0000256|ARBA:ARBA00022765};
KW   Chromosome {ECO:0000256|PIRNR:PIRNR000489};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PIRNR:PIRNR000489};
KW   Glycosyltransferase {ECO:0000256|ARBA:ARBA00022676,
KW   ECO:0000256|PIRNR:PIRNR000489};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW   ECO:0000256|PIRNR:PIRNR000489};
KW   NAD {ECO:0000256|ARBA:ARBA00023027, ECO:0000256|PIRNR:PIRNR000489};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PIRNR:PIRNR000489};
KW   Reference proteome {ECO:0000313|Proteomes:UP000283210};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PIRNR:PIRNR000489};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|PIRNR:PIRNR000489};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT   DOMAIN          10..92
FT                   /note="PARP-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50064"
FT   DOMAIN          114..204
FT                   /note="PARP-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50064"
FT   DOMAIN          388..464
FT                   /note="BRCT"
FT                   /evidence="ECO:0000259|PROSITE:PS50172"
FT   DOMAIN          663..780
FT                   /note="PARP alpha-helical"
FT                   /evidence="ECO:0000259|PROSITE:PS51060"
FT   DOMAIN          789..1015
FT                   /note="PARP catalytic"
FT                   /evidence="ECO:0000259|PROSITE:PS51059"
FT   REGION          199..225
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          357..393
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          495..527
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          401..421
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        509..523
FT                   /note="Polyampholyte"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1015 AA;  112866 MW;  6F252885537EE33E CRC64;
     MADSQNDKLF RAEYAKSGQA SCKKCKEKIA KESLRMAIVV QSPMFDGKVP HWHHFSCFWQ
     RASVQSTADV GGFSDLRWAD QEAVKKAIES GGVAGTGKGN SGSAAKGEKT LNDFAVEYAK
     SNRSTCKGCQ QKIEKDQIRV SKKVVDPEKP QLGLIDRWYH TACFVSSREE LAFKPNYSAA
     QLKGFNALRA EDKEELKKRL PAVKTEGKRP GDELDGVSKK LKQEEEEENK KLVENLKNQS
     QLIWGIKDKL RKHCSTNDMK ELLIANAQDV PSGESNVVDR VADGMAFGAL EACKECQGQL
     VFKGDAYYCT GDISAWTKCV FKTTTPPRKD WIIPKEFHEV PFLKKFKFKR QDRVYPKEAP
     TQTVTTAKGE PLASGSGALK EPLPEGAPSD KPLTGMKLLA VGKLSKNKEE LKTEVEEMGG
     KITGTANKAS LCLSTKKEVE KMGKKMEEIR DAGVRVVSED FLRDIKSSGK ALQELVSLHA
     ISTWGAEVKV EPQAPAAASK SGALAAKSTG RVKEEEGGNK SKKMKLTVKG GAAVDPDSGL
     ENSAHVLEQS GKMYSATLGL VDIVRGTNSY YKLQLLEDDL HKRYWVFRSW GRVGTTIGGN
     KLDKFHDKNS ALDNFLSVYK EKTGNEWGSS NFIKYPTKFY PLEIDYGQDE EAVKRLTASA
     GTKSKLAKPV QELIKMIFDV ESMKKAMVEF EIDLQKMPLG KLSKRQIQSA YALLTEVQQA
     VSDCVPEAQI LDLSNRFYTL IPHDFGMKKP PLLNSLDYIQ AKVEMLDNLL DIEVAYSLLR
     GGAQDNEHDP IDINYEKLKT KIEVVDKSSQ EAEVITQYVK NTHAATHNTY TLEVQEIFKI
     GREGERQRFR PFEELHNRQL LWHGSRTTNY AGIMSQGLRI APPEAPVTGY MFGKGVYFAD
     MVSKSANYCH TSQSDPVGLL LLAEVALGNM HELKKASHIT KLPKGKHSVK GLGRTAPDPN
     ATVTLDGVQV PLGKGVQTNI DDTSLLYNEY IVYDVAQINL KYLLKIKFNY QTSLW
//