ID A0A3R1BC11_ECOLX Unreviewed; 337 AA. AC A0A3R1BC11; DT 10-APR-2019, integrated into UniProtKB/TrEMBL. DT 10-APR-2019, sequence version 1. DT 07-OCT-2020, entry version 9. DE RecName: Full=N(1)-alpha-phosphoribosyltransferase {ECO:0000256|ARBA:ARBA00020318}; DE EC=2.4.2.21 {ECO:0000256|ARBA:ARBA00011991}; DE AltName: Full=Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase {ECO:0000256|ARBA:ARBA00015486}; DE Flags: Fragment; GN Name=cobT {ECO:0000313|EMBL:MMM60711.1}; GN ORFNames=D4U49_27250 {ECO:0000313|EMBL:EAB7206097.1}, D7Y10_26305 GN {ECO:0000313|EMBL:MMI30873.1}, D9L99_26125 GN {ECO:0000313|EMBL:MMM60711.1}, DLX38_25530 GN {ECO:0000313|EMBL:EAA0955231.1}, DM272_26300 GN {ECO:0000313|EMBL:EAA1960783.1}, DOM23_25370 GN {ECO:0000313|EMBL:EAA3231622.1}; OS Escherichia coli. OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; OC Enterobacteriaceae; Escherichia. OX NCBI_TaxID=562 {ECO:0000313|EMBL:MMM60711.1, ECO:0000313|Proteomes:UP000275882}; RN [1] {ECO:0000313|EMBL:EAA1960783.1, ECO:0000313|Proteomes:UP000376288, ECO:0000313|Proteomes:UP000406666} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=316340 {ECO:0000313|EMBL:EAA1960783.1, RC ECO:0000313|Proteomes:UP000376288}, 342603 RC {ECO:0000313|EMBL:EAA0955231.1, ECO:0000313|Proteomes:UP000366423}, RC 432167 {ECO:0000313|EMBL:EAA3231622.1, RC ECO:0000313|Proteomes:UP000406666}, and 587367 RC {ECO:0000313|EMBL:EAB7206097.1, ECO:0000313|Proteomes:UP000343782}; RA Ashton P.M., Dallman T., Nair S., De Pinna E., Peters T., Grant K.; RL Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|EMBL:MMM60711.1, ECO:0000313|Proteomes:UP000275882} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=PNUSAE018855 {ECO:0000313|EMBL:MMI30873.1, RC ECO:0000313|Proteomes:UP000268916}, and PNUSAE019090 RC {ECO:0000313|EMBL:MMM60711.1, ECO:0000313|Proteomes:UP000275882}; RG PulseNet: The National Subtyping Network for Foodborne Disease Surveillance; RA Tarr C.L., Trees E., Katz L.S., Carleton-Romer H.A., Stroika S., RA Kucerova Z., Roache K.F., Sabol A.L., Besser J., Gerner-Smidt P.; RL Submitted (OCT-2018) to the EMBL/GenBank/DDBJ databases. CC -!- CATALYTIC ACTIVITY: CC Reaction=5,6-dimethylbenzimidazole + nicotinate beta-D-ribonucleotide = CC alpha-ribazole 5'-phosphate + H(+) + nicotinate; CC Xref=Rhea:RHEA:11196, ChEBI:CHEBI:15378, ChEBI:CHEBI:15890, CC ChEBI:CHEBI:32544, ChEBI:CHEBI:57502, ChEBI:CHEBI:57918; EC=2.4.2.21; CC Evidence={ECO:0000256|ARBA:ARBA00001058}; CC -!- PATHWAY: Nucleoside biosynthesis; alpha-ribazole biosynthesis; alpha- CC ribazole from 5,6-dimethylbenzimidazole: step 1/2. CC {ECO:0000256|ARBA:ARBA00005049}. CC -!- SIMILARITY: Belongs to the CobT family. CC {ECO:0000256|ARBA:ARBA00007110}. CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ CC whole genome shotgun (WGS) entry which is preliminary data. CC {ECO:0000313|EMBL:MMM60711.1}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AAAAKE010000222; EAA0955231.1; -; Genomic_DNA. DR EMBL; AAAASZ010000157; EAA1960783.1; -; Genomic_DNA. DR EMBL; AAABCK010000170; EAA3231622.1; -; Genomic_DNA. DR EMBL; AAAFOP010000187; EAB7206097.1; -; Genomic_DNA. DR EMBL; RVTH01000157; MMI30873.1; -; Genomic_DNA. DR EMBL; RVWF01000171; MMM60711.1; -; Genomic_DNA. DR UniPathway; UPA00061; UER00516. DR Proteomes; UP000268916; Unassembled WGS sequence. DR Proteomes; UP000275882; Unassembled WGS sequence. DR Proteomes; UP000343782; Unassembled WGS sequence. DR Proteomes; UP000366423; Unassembled WGS sequence. DR Proteomes; UP000376288; Unassembled WGS sequence. DR Proteomes; UP000406666; Unassembled WGS sequence. DR GO; GO:0008939; F:nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity; IEA:UniProtKB-EC. DR GO; GO:0009236; P:cobalamin biosynthetic process; IEA:UniProtKB-KW. DR GO; GO:0009163; P:nucleoside biosynthetic process; IEA:InterPro. DR CDD; cd02439; DMB-PRT_CobT; 1. DR Gene3D; 1.10.1610.10; -; 1. DR Gene3D; 3.40.50.10210; -; 1. DR HAMAP; MF_00230; CobT; 1. DR InterPro; IPR003200; Nict_dMeBzImd_PRibTrfase-like. DR InterPro; IPR023195; Nict_dMeBzImd_PRibTrfase_N. DR InterPro; IPR017846; Nict_dMeBzImd_PRibTrfase_pro. DR InterPro; IPR036087; Nict_dMeBzImd_PRibTrfase_sf. DR Pfam; PF02277; DBI_PRT; 1. DR SUPFAM; SSF52733; SSF52733; 1. DR TIGRFAMs; TIGR03160; cobT_DBIPRT; 1. PE 3: Inferred from homology; KW Cobalamin biosynthesis {ECO:0000256|ARBA:ARBA00022573}; KW Glycosyltransferase {ECO:0000256|ARBA:ARBA00022676, KW ECO:0000313|EMBL:MMM60711.1}; KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:MMM60711.1}. FT DOMAIN 11..337 FT /note="DBI_PRT" FT /evidence="ECO:0000259|Pfam:PF02277" FT NON_TER 337 FT /evidence="ECO:0000313|EMBL:MMM60711.1" SQ SEQUENCE 337 AA; 34714 MW; C6E54BEA6F64C2D3 CRC64; MQTLADLLNT IPAIDPAAMS RAQRHIDGLL KPVGSLGRLE ALAIQLAGMP GLNGIPHVGK KAVLVMCADH GVWEEGVAIS PKEVTAIQAE NMTRGTTGVC VLAAQAGANV HVVDVGIDSA EPIPGLINMR VARGSGNIAS APAMSRRQAE KLLLDVICYT RELAKNGVTL FGVGELGMAN TTPAAAIVST ITGRDPEEVV GIGANLPTDK LANKIDVVRR AITLNQPNPQ DGVDVLAKVG GFDLVGMAGV MLGAASCGLP VLLDGFLSYA AALAACQMSP AIKPYLIPSH LSAEKGARIA LSHLGLEPYL NMEMRLGEGS GAALAMPIIE AACAIYN //