ID A0A3R1BC11_ECOLX Unreviewed; 337 AA. AC A0A3R1BC11; DT 10-APR-2019, integrated into UniProtKB/TrEMBL. DT 10-APR-2019, sequence version 1. DT 03-JUL-2019, entry version 4. DE RecName: Full=Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase {ECO:0000256|SAAS:SAAS00726629}; DE EC=2.4.2.21 {ECO:0000256|SAAS:SAAS00726625}; DE Flags: Fragment; GN Name=cobT {ECO:0000313|EMBL:MMM60711.1}; GN ORFNames=D7Y10_26305 {ECO:0000313|EMBL:MMI30873.1}, D9L99_26125 GN {ECO:0000313|EMBL:MMM60711.1}; OS Escherichia coli. OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; OC Enterobacteriaceae; Escherichia. OX NCBI_TaxID=562 {ECO:0000313|EMBL:MMM60711.1, ECO:0000313|Proteomes:UP000275882}; RN [1] {ECO:0000313|EMBL:MMM60711.1, ECO:0000313|Proteomes:UP000275882} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=PNUSAE018855 {ECO:0000313|EMBL:MMI30873.1, RC ECO:0000313|Proteomes:UP000268916}, and PNUSAE019090 RC {ECO:0000313|EMBL:MMM60711.1, ECO:0000313|Proteomes:UP000275882}; RG PulseNet: The National Subtyping Network for Foodborne Disease Surveillance; RA Tarr C.L., Trees E., Katz L.S., Carleton-Romer H.A., Stroika S., RA Kucerova Z., Roache K.F., Sabol A.L., Besser J., Gerner-Smidt P.; RL Submitted (OCT-2018) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Catalyzes the synthesis of alpha-ribazole-5'-phosphate CC from nicotinate mononucleotide (NAMN) and 5,6- CC dimethylbenzimidazole (DMB). {ECO:0000256|SAAS:SAAS00726623}. CC -!- CATALYTIC ACTIVITY: CC Reaction=5,6-dimethylbenzimidazole + nicotinate beta-D- CC ribonucleotide = alpha-ribazole 5'-phosphate + H(+) + CC nicotinate; Xref=Rhea:RHEA:11196, ChEBI:CHEBI:15378, CC ChEBI:CHEBI:15890, ChEBI:CHEBI:32544, ChEBI:CHEBI:57502, CC ChEBI:CHEBI:57918; EC=2.4.2.21; CC Evidence={ECO:0000256|SAAS:SAAS01116081}; CC -!- PATHWAY: Nucleoside biosynthesis; alpha-ribazole biosynthesis; CC alpha-ribazole from 5,6-dimethylbenzimidazole: step 1/2. CC {ECO:0000256|SAAS:SAAS00726628}. CC -!- SIMILARITY: Belongs to the CobT family. CC {ECO:0000256|SAAS:SAAS00726624}. CC -!- CAUTION: The sequence shown here is derived from an CC EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is CC preliminary data. {ECO:0000313|EMBL:MMM60711.1}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; RVTH01000157; MMI30873.1; -; Genomic_DNA. DR EMBL; RVWF01000171; MMM60711.1; -; Genomic_DNA. DR UniPathway; UPA00061; UER00516. DR Proteomes; UP000268916; Unassembled WGS sequence. DR Proteomes; UP000275882; Unassembled WGS sequence. DR GO; GO:0008939; F:nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity; IEA:UniProtKB-EC. DR GO; GO:0009236; P:cobalamin biosynthetic process; IEA:UniProtKB-KW. DR GO; GO:0009163; P:nucleoside biosynthetic process; IEA:InterPro. DR CDD; cd02439; DMB-PRT_CobT; 1. DR Gene3D; 1.10.1610.10; -; 1. DR HAMAP; MF_00230; CobT; 1. DR InterPro; IPR003200; Nict_dMeBzImd_PRibTrfase-like. DR InterPro; IPR023195; Nict_dMeBzImd_PRibTrfase_N. DR InterPro; IPR017846; Nict_dMeBzImd_PRibTrfase_pro. DR InterPro; IPR036087; Nict_dMeBzImd_PRibTrfase_sf. DR Pfam; PF02277; DBI_PRT; 1. DR SUPFAM; SSF52733; SSF52733; 1. DR TIGRFAMs; TIGR03160; cobT_DBIPRT; 1. PE 3: Inferred from homology; KW Cobalamin biosynthesis {ECO:0000256|SAAS:SAAS00726630}; KW Complete proteome {ECO:0000313|Proteomes:UP000268916, KW ECO:0000313|Proteomes:UP000275882}; KW Glycosyltransferase {ECO:0000256|SAAS:SAAS00726626, KW ECO:0000313|EMBL:MMM60711.1}; KW Transferase {ECO:0000256|SAAS:SAAS00726622, KW ECO:0000313|EMBL:MMM60711.1}. FT DOMAIN 11 337 DBI_PRT. {ECO:0000259|Pfam:PF02277}. FT NON_TER 337 337 {ECO:0000313|EMBL:MMM60711.1}. SQ SEQUENCE 337 AA; 34714 MW; C6E54BEA6F64C2D3 CRC64; MQTLADLLNT IPAIDPAAMS RAQRHIDGLL KPVGSLGRLE ALAIQLAGMP GLNGIPHVGK KAVLVMCADH GVWEEGVAIS PKEVTAIQAE NMTRGTTGVC VLAAQAGANV HVVDVGIDSA EPIPGLINMR VARGSGNIAS APAMSRRQAE KLLLDVICYT RELAKNGVTL FGVGELGMAN TTPAAAIVST ITGRDPEEVV GIGANLPTDK LANKIDVVRR AITLNQPNPQ DGVDVLAKVG GFDLVGMAGV MLGAASCGLP VLLDGFLSYA AALAACQMSP AIKPYLIPSH LSAEKGARIA LSHLGLEPYL NMEMRLGEGS GAALAMPIIE AACAIYN //