ID A0A3R1BC11_ECOLX Unreviewed; 337 AA. AC A0A3R1BC11; DT 10-APR-2019, integrated into UniProtKB/TrEMBL. DT 10-APR-2019, sequence version 1. DT 13-SEP-2023, entry version 19. DE RecName: Full=Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase {ECO:0000256|ARBA:ARBA00015486}; DE EC=2.4.2.21 {ECO:0000256|ARBA:ARBA00011991}; DE AltName: Full=N(1)-alpha-phosphoribosyltransferase {ECO:0000256|ARBA:ARBA00030686}; DE Flags: Fragment; GN Name=cobT {ECO:0000313|EMBL:EAB7206097.1}; GN ORFNames=D4U49_27250 {ECO:0000313|EMBL:EAB7206097.1}; OS Escherichia coli. OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; OC Enterobacteriaceae; Escherichia. OX NCBI_TaxID=562 {ECO:0000313|EMBL:EAB7206097.1}; RN [1] {ECO:0000313|EMBL:EAB7206097.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=587367 {ECO:0000313|EMBL:EAB7206097.1}; RA Ashton P.M., Dallman T., Nair S., De Pinna E., Peters T., Grant K.; RL Submitted (SEP-2018) to the EMBL/GenBank/DDBJ databases. CC -!- CATALYTIC ACTIVITY: CC Reaction=5,6-dimethylbenzimidazole + nicotinate beta-D-ribonucleotide = CC alpha-ribazole 5'-phosphate + H(+) + nicotinate; CC Xref=Rhea:RHEA:11196, ChEBI:CHEBI:15378, ChEBI:CHEBI:15890, CC ChEBI:CHEBI:32544, ChEBI:CHEBI:57502, ChEBI:CHEBI:57918; EC=2.4.2.21; CC Evidence={ECO:0000256|ARBA:ARBA00001058}; CC -!- PATHWAY: Nucleoside biosynthesis; alpha-ribazole biosynthesis; alpha- CC ribazole from 5,6-dimethylbenzimidazole: step 1/2. CC {ECO:0000256|ARBA:ARBA00005049}. CC -!- SIMILARITY: Belongs to the CobT family. CC {ECO:0000256|ARBA:ARBA00007110}. CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ CC whole genome shotgun (WGS) entry which is preliminary data. CC {ECO:0000313|EMBL:EAB7206097.1}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AAAFOP010000187; EAB7206097.1; -; Genomic_DNA. DR AlphaFoldDB; A0A3R1BC11; -. DR UniPathway; UPA00061; UER00516. DR GO; GO:0008939; F:nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity; IEA:UniProtKB-EC. DR GO; GO:0009236; P:cobalamin biosynthetic process; IEA:UniProtKB-KW. DR CDD; cd02439; DMB-PRT_CobT; 1. DR Gene3D; 1.10.1610.10; -; 1. DR Gene3D; 3.40.50.10210; -; 1. DR HAMAP; MF_00230; CobT; 1. DR InterPro; IPR003200; Nict_dMeBzImd_PRibTrfase. DR InterPro; IPR017846; Nict_dMeBzImd_PRibTrfase_bact. DR InterPro; IPR023195; Nict_dMeBzImd_PRibTrfase_N. DR InterPro; IPR036087; Nict_dMeBzImd_PRibTrfase_sf. DR NCBIfam; TIGR03160; cobT_DBIPRT; 1. DR PANTHER; PTHR43463; NICOTINATE-NUCLEOTIDE--DIMETHYLBENZIMIDAZOLE PHOSPHORIBOSYLTRANSFERASE; 1. DR PANTHER; PTHR43463:SF1; NICOTINATE-NUCLEOTIDE--DIMETHYLBENZIMIDAZOLE PHOSPHORIBOSYLTRANSFERASE; 1. DR Pfam; PF02277; DBI_PRT; 1. DR SUPFAM; SSF52733; Nicotinate mononucleotide:5,6-dimethylbenzimidazole phosphoribosyltransferase (CobT); 1. PE 3: Inferred from homology; KW Cobalamin biosynthesis {ECO:0000256|ARBA:ARBA00022573}; KW Glycosyltransferase {ECO:0000256|ARBA:ARBA00022676, KW ECO:0000313|EMBL:EAB7206097.1}; KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:EAB7206097.1}. FT NON_TER 337 FT /evidence="ECO:0000313|EMBL:EAB7206097.1" SQ SEQUENCE 337 AA; 34714 MW; C6E54BEA6F64C2D3 CRC64; MQTLADLLNT IPAIDPAAMS RAQRHIDGLL KPVGSLGRLE ALAIQLAGMP GLNGIPHVGK KAVLVMCADH GVWEEGVAIS PKEVTAIQAE NMTRGTTGVC VLAAQAGANV HVVDVGIDSA EPIPGLINMR VARGSGNIAS APAMSRRQAE KLLLDVICYT RELAKNGVTL FGVGELGMAN TTPAAAIVST ITGRDPEEVV GIGANLPTDK LANKIDVVRR AITLNQPNPQ DGVDVLAKVG GFDLVGMAGV MLGAASCGLP VLLDGFLSYA AALAACQMSP AIKPYLIPSH LSAEKGARIA LSHLGLEPYL NMEMRLGEGS GAALAMPIIE AACAIYN //