ID A0A3Q7Y033_URSAR Unreviewed; 866 AA. AC A0A3Q7Y033; DT 10-APR-2019, integrated into UniProtKB/TrEMBL. DT 10-APR-2019, sequence version 1. DT 19-JAN-2022, entry version 14. DE SubName: Full=E3 ubiquitin-protein ligase TRIM37 isoform X4 {ECO:0000313|RefSeq:XP_026373244.1}; GN Name=TRIM37 {ECO:0000313|RefSeq:XP_026373244.1}; OS Ursus arctos horribilis. OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus. OX NCBI_TaxID=116960 {ECO:0000313|Proteomes:UP000286642, ECO:0000313|RefSeq:XP_026373244.1}; RN [1] RP IDENTIFICATION. RG RefSeq; RL Submitted (JAN-2019) to UniProtKB. RN [2] {ECO:0000313|RefSeq:XP_026373244.1} RP IDENTIFICATION. RC TISSUE=Blood {ECO:0000313|RefSeq:XP_026373244.1}; RG RefSeq; RL Submitted (FEB-2021) to UniProtKB. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR RefSeq; XP_026373244.1; XM_026517459.1. DR Proteomes; UP000286642; Genome assembly. DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW. DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro. DR GO; GO:0016567; P:protein ubiquitination; IEA:InterPro. DR CDD; cd03773; MATH_TRIM37; 1. DR Gene3D; 2.60.210.10; -; 1. DR Gene3D; 3.30.40.10; -; 1. DR InterPro; IPR003649; Bbox_C. DR InterPro; IPR002083; MATH/TRAF_dom. DR InterPro; IPR008974; TRAF-like. DR InterPro; IPR037299; TRIM37_MATH. DR InterPro; IPR000315; Znf_B-box. DR InterPro; IPR001841; Znf_RING. DR InterPro; IPR013083; Znf_RING/FYVE/PHD. DR Pfam; PF00917; MATH; 1. DR Pfam; PF00643; zf-B_box; 1. DR SMART; SM00502; BBC; 1. DR SMART; SM00336; BBOX; 1. DR SMART; SM00061; MATH; 1. DR PROSITE; PS50144; MATH; 1. DR PROSITE; PS50119; ZF_BBOX; 1. DR PROSITE; PS50089; ZF_RING_2; 1. PE 4: Predicted; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490}; KW Metal-binding {ECO:0000256|ARBA:ARBA00022723}; KW Reference proteome {ECO:0000313|Proteomes:UP000286642}; KW Zinc {ECO:0000256|ARBA:ARBA00022833}; KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE- KW ProRule:PRU00024}. FT DOMAIN 15..55 FT /note="RING-type" FT /evidence="ECO:0000259|PROSITE:PS50089" FT DOMAIN 90..132 FT /note="B box-type" FT /evidence="ECO:0000259|PROSITE:PS50119" FT DOMAIN 276..403 FT /note="MATH" FT /evidence="ECO:0000259|PROSITE:PS50144" FT REGION 447..477 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 495..515 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 529..561 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 640..711 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 784..866 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COILED 133..181 FT /evidence="ECO:0000256|SAM:Coils" FT COILED 208..228 FT /evidence="ECO:0000256|SAM:Coils" FT COMPBIAS 531..547 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 645..665 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 682..711 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 866 AA; 97214 MW; 1143CBF54C0981C4 CRC64; MDEQSVESIA EVFRCFICME KLRDARLCPH CSKLCCFSCI RRWLTEQRAQ CPHCRAPLQL RELVNCRWAE EVTQQLDTLQ LCSLTKHEEN EKDKCENHHE KLSVFCWTCK KCICHQCALW GGMHGGHTFK PLAEIYEQHV TKVNEEVAKL RRRLMELISL VQEVERNVEA VRNAKDERVR EIRNAVEMMI ARLDTQLKNK LITLMGQKTS LTQETELLES LLQEVEHQLR SCSKSELISK SSEILMMFQQ VHRKPMASFV TTPVPPDFTS ELVPSYDSAT FVLENFSTLR QRADPVYSPP LQVSGLCWRL KVYPDGNGVV RGYYLSVFLE LSAGLPETSK YEYRVEMVHQ SCNDPTKNII REFASDFEVG ECWGYNRFFR LDLLANEGYL NRQNDTVILR FQVRSPTFFQ KCRDQHWYIT QLEAAQTSYI QQINNLKERL TIELSRTQKS RDLSPPDNHL SPQNDDTPEA RAKKSVSCTD MLLQDGPTTA SIREVKEDEE EEEKIQNEDY HHELSDGDLD LDLVGEDEVN HLDGSSSSAS STATSNTEEN DIDEETMSGE NDVEYNNMEL EEGELMEDAA AAGPPGSNHG YVGASSRMSR RAHLCSAATS SLLDIDPLIL IHLLDLKDRS SMENLWGLQP RPPASLLQPT ATNKKSNSPK PARSSVAGSL SLRRAIDSGE NSRSKGDCQT LSEGSPGSSQ SGSRRSSPRA LTHDTISDIL PKSEDRQCQA LGSDAVVVAV FSGLPAVEKR RKMVTLGLFS PLRANAKGGR LEGMQMTDLE NNSETGELQP ILPEGASAAP EEGMSSDSDI ECDTENEEQE EHASMGGFDD SFMAQPPDED THSSFPDGEQ IGPEDLSFNT DGNSGR //