ID A0A3Q4GML1_NEOBR Unreviewed; 731 AA. AC A0A3Q4GML1; DT 10-APR-2019, integrated into UniProtKB/TrEMBL. DT 10-APR-2019, sequence version 1. DT 19-JAN-2022, entry version 15. DE RecName: Full=Diacylglycerol kinase {ECO:0000256|RuleBase:RU361128}; DE Short=DAG kinase {ECO:0000256|RuleBase:RU361128}; DE EC=2.7.1.107 {ECO:0000256|RuleBase:RU361128}; OS Neolamprologus brichardi (Fairy cichlid) (Lamprologus brichardi). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids; OC Pseudocrenilabrinae; Lamprologini; Neolamprologus. OX NCBI_TaxID=32507 {ECO:0000313|Ensembl:ENSNBRP00000008003, ECO:0000313|Proteomes:UP000261580}; RN [1] {ECO:0000313|Ensembl:ENSNBRP00000008003} RP IDENTIFICATION. RG Ensembl; RL Submitted (JAN-2019) to UniProtKB. CC -!- CATALYTIC ACTIVITY: CC Reaction=1,2-di-(9Z-octadecenoyl)-sn-glycerol + ATP = 1,2-di-(9Z- CC octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+); CC Xref=Rhea:RHEA:40327, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, CC ChEBI:CHEBI:52333, ChEBI:CHEBI:74546, ChEBI:CHEBI:456216; CC Evidence={ECO:0000256|ARBA:ARBA00023371}; CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40328; CC Evidence={ECO:0000256|ARBA:ARBA00023371}; CC -!- CATALYTIC ACTIVITY: CC Reaction=1,2-didecanoyl-sn-glycerol + ATP = 1,2-didecanoyl-sn-glycero- CC 3-phosphate + ADP + H(+); Xref=Rhea:RHEA:43428, ChEBI:CHEBI:15378, CC ChEBI:CHEBI:18155, ChEBI:CHEBI:30616, ChEBI:CHEBI:78227, CC ChEBI:CHEBI:456216; Evidence={ECO:0000256|ARBA:ARBA00023395}; CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:43429; CC Evidence={ECO:0000256|ARBA:ARBA00023395}; CC -!- CATALYTIC ACTIVITY: CC Reaction=1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol CC + ATP = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero- CC 3-phosphate + ADP + H(+); Xref=Rhea:RHEA:40323, ChEBI:CHEBI:15378, CC ChEBI:CHEBI:30616, ChEBI:CHEBI:75728, ChEBI:CHEBI:77091, CC ChEBI:CHEBI:456216; Evidence={ECO:0000256|ARBA:ARBA00023400}; CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40324; CC Evidence={ECO:0000256|ARBA:ARBA00023400}; CC -!- CATALYTIC ACTIVITY: CC Reaction=a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3- CC phosphate + ADP + H(+); Xref=Rhea:RHEA:10272, ChEBI:CHEBI:15378, CC ChEBI:CHEBI:17815, ChEBI:CHEBI:30616, ChEBI:CHEBI:58608, CC ChEBI:CHEBI:456216; EC=2.7.1.107; CC Evidence={ECO:0000256|ARBA:ARBA00023411}; CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:10273; CC Evidence={ECO:0000256|ARBA:ARBA00023411}; CC -!- PATHWAY: Lipid metabolism; glycerolipid metabolism. CC {ECO:0000256|ARBA:ARBA00005175}. CC -!- SIMILARITY: Belongs to the eukaryotic diacylglycerol kinase family. CC {ECO:0000256|ARBA:ARBA00009280, ECO:0000256|RuleBase:RU361128}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR RefSeq; XP_006794133.1; XM_006794070.1. DR STRING; 32507.XP_006794133.1; -. DR Ensembl; ENSNBRT00000008226; ENSNBRP00000008003; ENSNBRG00000006079. DR GeneID; 102798251; -. DR CTD; 724010; -. DR GeneTree; ENSGT00940000157144; -. DR OMA; MQAPCTI; -. DR UniPathway; UPA00230; -. DR Proteomes; UP000261580; Unplaced. DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW. DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro. DR GO; GO:0004143; F:diacylglycerol kinase activity; IEA:UniProtKB-EC. DR GO; GO:0003951; F:NAD+ kinase activity; IEA:InterPro. DR GO; GO:0046486; P:glycerolipid metabolic process; IEA:UniProtKB-UniPathway. DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro. DR GO; GO:0007205; P:protein kinase C-activating G protein-coupled receptor signaling pathway; IEA:InterPro. DR CDD; cd00029; C1; 1. DR CDD; cd00051; EFh; 1. DR Gene3D; 1.10.238.110; -; 1. DR Gene3D; 3.40.50.10330; -; 1. DR InterPro; IPR017438; ATP-NAD_kinase_N. DR InterPro; IPR029477; DAG_kinase_typeI_N. DR InterPro; IPR037607; DGK. DR InterPro; IPR038199; DGK_typeI_N_sf. DR InterPro; IPR000756; Diacylglycerol_kin_accessory. DR InterPro; IPR001206; Diacylglycerol_kinase_cat_dom. DR InterPro; IPR011992; EF-hand-dom_pair. DR InterPro; IPR018247; EF_Hand_1_Ca_BS. DR InterPro; IPR002048; EF_hand_dom. DR InterPro; IPR016064; NAD/diacylglycerol_kinase_sf. DR InterPro; IPR002219; PE/DAG-bd. DR PANTHER; PTHR11255; PTHR11255; 1. DR Pfam; PF00130; C1_1; 2. DR Pfam; PF14513; DAG_kinase_N; 1. DR Pfam; PF00609; DAGK_acc; 1. DR Pfam; PF00781; DAGK_cat; 1. DR Pfam; PF13499; EF-hand_7; 1. DR SMART; SM00109; C1; 2. DR SMART; SM00045; DAGKa; 1. DR SMART; SM00046; DAGKc; 1. DR SMART; SM00054; EFh; 2. DR SUPFAM; SSF111331; SSF111331; 1. DR SUPFAM; SSF47473; SSF47473; 2. DR PROSITE; PS50146; DAGK; 1. DR PROSITE; PS00018; EF_HAND_1; 2. DR PROSITE; PS50222; EF_HAND_2; 2. DR PROSITE; PS00479; ZF_DAG_PE_1; 1. DR PROSITE; PS50081; ZF_DAG_PE_2; 2. PE 3: Inferred from homology; KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU361128}; KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PROSITE- KW ProRule:PRU00448}; KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000256|RuleBase:RU361128}; KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098}; KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00448}; KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, KW ECO:0000256|RuleBase:RU361128}; KW Reference proteome {ECO:0000313|Proteomes:UP000261580}; KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU361128}; KW Zinc {ECO:0000256|ARBA:ARBA00022833}; KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}. FT DOMAIN 113..148 FT /note="EF-hand" FT /evidence="ECO:0000259|PROSITE:PS50222" FT DOMAIN 158..193 FT /note="EF-hand" FT /evidence="ECO:0000259|PROSITE:PS50222" FT DOMAIN 207..257 FT /note="Phorbol-ester/DAG-type" FT /evidence="ECO:0000259|PROSITE:PS50081" FT DOMAIN 272..322 FT /note="Phorbol-ester/DAG-type" FT /evidence="ECO:0000259|PROSITE:PS50081" FT DOMAIN 376..510 FT /note="DAGKc" FT /evidence="ECO:0000259|PROSITE:PS50146" FT CA_BIND 126..137 FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00448" FT CA_BIND 171..182 FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00448" SQ SEQUENCE 731 AA; 81944 MW; B0B1B991C30C47E4 CRC64; MSSPTNPEVK ELNPVDFIQL QQYIEYNNLK VKDVLREFYA DGSLARHRHG ECINEEGFRL FLKTYLEVED FPVDLCQRLF RSFQNSEPGQ EDSTKEVFLK DVSCYFSLLE DGQPRDKLEF AFRLYDRDGN GVLDSSEVDR IIAQMMHAAE YLDWDVSELK PVLKDMMTAI DADSSGTVSL DEWVQGGMNN VPLLVLLGLK MTQKDGQHLW RMKNFNKPVY CNVCHSMLLG LRKQGLCCTS CKYTVHGRCA NKNPAPCART YVKSKKEIGV STHDWVSGNC DSRKCDKCQK KIKSLQGLTG KHCVWCHTMR HDQCVDQEST QCTCGLLRDH ILPPWAIYPV IKERPNNVKN GCSGSGDDSE LNTTPDGQVL QICPVLNAHP LLVFVNPKSG GKQGERVLRK FQFLLNPRQV YNLSNGGPGP GLSFFRNLKE YRILVCGGDG TVGWILDAID KGNLLVRPPV AVLPLGTGND LARCLRWGGG YDGEDLNRIL KDIEGSSQVL MDRWSVQVIT DENQEEGDPV PYEIINNYFS IGVDASIAHR FHTMREKHPQ KFNSRMKNKL WYFEFATSET ISASCKKLSE NLTIECCGTA LDLSGVSLEG VAILNIPSMH GGSNLWGETK KVDTKGLTAQ EEPEVIVNPE ILKVTSQDLS DRRLEVVGLE GAMEMGQIYT GLKSAVRLAK TSQITIRTKK ALPMQIDGEP WMQPPCTIQI THKNQACMLM GPPAKPSGFF K //