ID   A0A3Q4GAV3_NEOBR        Unreviewed;       825 AA.
AC   A0A3Q4GAV3;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   17-JUN-2020, entry version 8.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSNBRP00000005611};
OS   Neolamprologus brichardi (Fairy cichlid) (Lamprologus brichardi).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Lamprologini; Neolamprologus.
OX   NCBI_TaxID=32507 {ECO:0000313|Ensembl:ENSNBRP00000005611};
RN   [1] {ECO:0000313|Ensembl:ENSNBRP00000005611}
RP   NUCLEOTIDE SEQUENCE.
RA   Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA   MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RL   Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSNBRP00000005611}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=25186727; DOI=10.1038/nature13726;
RA   Brawand D., Wagner C.E., Li Y.I., Malinsky M., Keller I., Fan S.,
RA   Simakov O., Ng A.Y., Lim Z.W., Bezault E., Turner-Maier J., Johnson J.,
RA   Alcazar R., Noh H.J., Russell P., Aken B., Alfoldi J., Amemiya C.,
RA   Azzouzi N., Baroiller J.F., Barloy-Hubler F., Berlin A., Bloomquist R.,
RA   Carleton K.L., Conte M.A., D'Cotta H., Eshel O., Gaffney L., Galibert F.,
RA   Gante H.F., Gnerre S., Greuter L., Guyon R., Haddad N.S., Haerty W.,
RA   Harris R.M., Hofmann H.A., Hourlier T., Hulata G., Jaffe D.B., Lara M.,
RA   Lee A.P., MacCallum I., Mwaiko S., Nikaido M., Nishihara H.,
RA   Ozouf-Costaz C., Penman D.J., Przybylski D., Rakotomanga M., Renn S.C.P.,
RA   Ribeiro F.J., Ron M., Salzburger W., Sanchez-Pulido L., Santos M.E.,
RA   Searle S., Sharpe T., Swofford R., Tan F.J., Williams L., Young S., Yin S.,
RA   Okada N., Kocher T.D., Miska E.A., Lander E.S., Venkatesh B., Fernald R.D.,
RA   Meyer A., Ponting C.P., Streelman J.T., Lindblad-Toh K., Seehausen O.,
RA   Di Palma F.;
RT   "The genomic substrate for adaptive radiation in African cichlid fish.";
RL   Nature 513:375-381(2014).
RN   [3] {ECO:0000313|Ensembl:ENSNBRP00000005611}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JAN-2019) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor Fz/Smo family.
CC       {ECO:0000256|SAAS:SAAS00874568}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00090}.
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DR   RefSeq; XP_006780762.1; XM_006780699.1.
DR   RefSeq; XP_006780763.1; XM_006780700.1.
DR   Ensembl; ENSNBRT00000005777; ENSNBRP00000005611; ENSNBRG00000004418.
DR   GeneID; 102780724; -.
DR   GeneTree; ENSGT00940000157206; -.
DR   OMA; DMHAYIA; -.
DR   Proteomes; UP000261580; Whole Genome Shotgun Assembly.
DR   GO; GO:0005929; C:cilium; IEA:Ensembl.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0008142; F:oxysterol binding; IEA:Ensembl.
DR   GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR   GO; GO:0021984; P:adenohypophysis development; IEA:Ensembl.
DR   GO; GO:0035479; P:angioblast cell migration from lateral mesoderm to midline; IEA:Ensembl.
DR   GO; GO:0009952; P:anterior/posterior pattern specification; IEA:Ensembl.
DR   GO; GO:0060844; P:arterial endothelial cell fate commitment; IEA:Ensembl.
DR   GO; GO:0003231; P:cardiac ventricle development; IEA:Ensembl.
DR   GO; GO:0010002; P:cardioblast differentiation; IEA:Ensembl.
DR   GO; GO:0051216; P:cartilage development; IEA:Ensembl.
DR   GO; GO:0035143; P:caudal fin morphogenesis; IEA:Ensembl.
DR   GO; GO:0021587; P:cerebellum morphogenesis; IEA:Ensembl.
DR   GO; GO:0060830; P:ciliary receptor clustering involved in smoothened signaling pathway; IEA:Ensembl.
DR   GO; GO:0071679; P:commissural neuron axon guidance; IEA:Ensembl.
DR   GO; GO:0035912; P:dorsal aorta morphogenesis; IEA:Ensembl.
DR   GO; GO:0031076; P:embryonic camera-type eye development; IEA:Ensembl.
DR   GO; GO:0048557; P:embryonic digestive tract morphogenesis; IEA:Ensembl.
DR   GO; GO:0048702; P:embryonic neurocranium morphogenesis; IEA:Ensembl.
DR   GO; GO:0009880; P:embryonic pattern specification; IEA:Ensembl.
DR   GO; GO:0048703; P:embryonic viscerocranium morphogenesis; IEA:Ensembl.
DR   GO; GO:0060956; P:endocardial cell differentiation; IEA:Ensembl.
DR   GO; GO:0031018; P:endocrine pancreas development; IEA:Ensembl.
DR   GO; GO:0072175; P:epithelial tube formation; IEA:Ensembl.
DR   GO; GO:0031017; P:exocrine pancreas development; IEA:Ensembl.
DR   GO; GO:0021508; P:floor plate formation; IEA:Ensembl.
DR   GO; GO:0021798; P:forebrain dorsal/ventral pattern formation; IEA:Ensembl.
DR   GO; GO:0021986; P:habenula development; IEA:Ensembl.
DR   GO; GO:0001947; P:heart looping; IEA:Ensembl.
DR   GO; GO:0042693; P:muscle cell fate commitment; IEA:Ensembl.
DR   GO; GO:0030239; P:myofibril assembly; IEA:Ensembl.
DR   GO; GO:0014033; P:neural crest cell differentiation; IEA:Ensembl.
DR   GO; GO:0001839; P:neural plate morphogenesis; IEA:Ensembl.
DR   GO; GO:0060896; P:neural plate pattern specification; IEA:Ensembl.
DR   GO; GO:0014003; P:oligodendrocyte development; IEA:Ensembl.
DR   GO; GO:0032474; P:otolith morphogenesis; IEA:Ensembl.
DR   GO; GO:0045880; P:positive regulation of smoothened signaling pathway; IEA:Ensembl.
DR   GO; GO:0060041; P:retina development in camera-type eye; IEA:Ensembl.
DR   GO; GO:0031290; P:retinal ganglion cell axon guidance; IEA:Ensembl.
DR   GO; GO:0048752; P:semicircular canal morphogenesis; IEA:Ensembl.
DR   GO; GO:0048741; P:skeletal muscle fiber development; IEA:Ensembl.
DR   GO; GO:0048745; P:smooth muscle tissue development; IEA:Ensembl.
DR   GO; GO:0021523; P:somatic motor neuron differentiation; IEA:Ensembl.
DR   GO; GO:0061053; P:somite development; IEA:Ensembl.
DR   GO; GO:0021520; P:spinal cord motor neuron cell fate specification; IEA:Ensembl.
DR   GO; GO:0048795; P:swim bladder morphogenesis; IEA:Ensembl.
DR   GO; GO:0021537; P:telencephalon development; IEA:Ensembl.
DR   GO; GO:0001570; P:vasculogenesis; IEA:Ensembl.
DR   CDD; cd07451; CRD_SMO; 1.
DR   Gene3D; 1.10.2000.10; -; 1.
DR   InterPro; IPR015526; Frizzled/SFRP.
DR   InterPro; IPR000539; Frizzled/Smoothened_TM.
DR   InterPro; IPR020067; Frizzled_dom.
DR   InterPro; IPR036790; Frizzled_dom_sf.
DR   InterPro; IPR017981; GPCR_2-like.
DR   InterPro; IPR026544; SMO.
DR   InterPro; IPR041771; SMO_CRD.
DR   PANTHER; PTHR11309; PTHR11309; 1.
DR   PANTHER; PTHR11309:SF35; PTHR11309:SF35; 1.
DR   Pfam; PF01534; Frizzled; 1.
DR   Pfam; PF01392; Fz; 1.
DR   PRINTS; PR00489; FRIZZLED.
DR   SMART; SM00063; FRI; 1.
DR   SMART; SM01330; Frizzled; 1.
DR   SUPFAM; SSF63501; SSF63501; 1.
DR   PROSITE; PS50038; FZ; 1.
DR   PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
PE   3: Inferred from homology;
KW   Developmental protein {ECO:0000256|SAAS:SAAS00427069};
KW   Disulfide bond {ECO:0000256|SAAS:SAAS00978052};
KW   Membrane {ECO:0000256|SAAS:SAAS00874221, ECO:0000256|SAM:Phobius};
KW   Receptor {ECO:0000256|SAAS:SAAS00874335};
KW   Reference proteome {ECO:0000313|Proteomes:UP000261580};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00874792, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00874766,
KW   ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..28
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           29..825
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5018714969"
FT   TRANSMEM        208..229
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        241..258
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        290..314
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        334..354
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        374..395
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        427..450
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        497..520
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          42..156
FT                   /note="FZ"
FT                   /evidence="ECO:0000259|PROSITE:PS50038"
FT   DOMAIN          205..468
FT                   /note="G_PROTEIN_RECEP_F2_4"
FT                   /evidence="ECO:0000259|PROSITE:PS50261"
SQ   SEQUENCE   825 AA;  93230 MW;  AEB9FB5FF4E70286 CRC64;
     MSSKSWSPIV GFYGMLCVWA AWLSGCGAVL SPNGTIFEDT CKKTSTCEVL KYNTCLGSPL
     PYTHTSLILA EDSSTQEEAF EKLTMWSGLR NAPRCWSVIQ PLLCAVYMPK CENGRVELPS
     QSLCLTTRSP CSIVDRERGW PSFLKCDKFP VGCSNEVQKL KFNTSGQCEA PLVKTDIQSS
     WYKDVEGCGI QCDNPLFTEE EHNDMHAYIA YFGTITLLCT FFTLATFLAD WKNSNRYPAV
     ILFYINACFF VGSIGWLAQF LDGAREEIVC KSDNTMRLGE PSSSETLSCV TIFIIVYYSL
     MSGVIWFVML TYAWHTSFKA LGTTHQPLSG RTSYFHMVTW SIPFVLTVAI LAIAEVDGDS
     VSGICFVGYK NYRYRAGFVL APIGVVLVVG GYFLIRGVMT LFSIKSNHPG LLSEKAASKI
     NETMLRLGIF GFLAFGFVFI TFGCHFYDFF NQAEWERSFR DYVLCEANVT IASQTNKPIP
     ECTIKNRPSL MVEKINLFSM FGTGIAMSTW VWTKATILIW KRTWCKIIGR SDNEPKRIKK
     SKMIAKAFAM RKELHKDPEK ELSFSMHTVS HEGPVAGINF DLNEPSNDMS SAWAQHVTKM
     VARRGAILPQ DISVTPTGTP VPPPEERNRL WMVEAEISPE MIKRKKKKKK RKKEVRPVEE
     MVDHQVYRQR EFGRSSVPRL PKLPPHPSLV ANLREQQRQQ QKIEEEVLPG SYPDFQPSRR
     LSCEEKCPYL QYQTSQNGYG HSMLSDPLTF RDRPEDLGLG PRYPPSNWQP SASSRYPGNM
     DITDGISERM AHVARVPAGR RAGYGPIHSR TNLMEAELMD ADSDF
//