ID A0A3Q4GAV3_NEOBR Unreviewed; 825 AA. AC A0A3Q4GAV3; DT 10-APR-2019, integrated into UniProtKB/TrEMBL. DT 10-APR-2019, sequence version 1. DT 16-OCT-2019, entry version 6. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSNBRP00000005611}; OS Neolamprologus brichardi (Fairy cichlid) (Lamprologus brichardi). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids; OC Pseudocrenilabrinae; Lamprologini; Neolamprologus. OX NCBI_TaxID=32507 {ECO:0000313|Ensembl:ENSNBRP00000005611, ECO:0000313|Proteomes:UP000261580}; RN [1] {ECO:0000313|Ensembl:ENSNBRP00000005611, ECO:0000313|Proteomes:UP000261580} RP NUCLEOTIDE SEQUENCE. RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D., RA MacCallum I., Young S., Walker B.J., Lindblad-Toh K.; RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSNBRP00000005611, ECO:0000313|Proteomes:UP000261580} RP NUCLEOTIDE SEQUENCE. RX PubMed=25186727; DOI=10.1038/nature13726; RA Brawand D., Wagner C.E., Li Y.I., Malinsky M., Keller I., Fan S., RA Simakov O., Ng A.Y., Lim Z.W., Bezault E., Turner-Maier J., RA Johnson J., Alcazar R., Noh H.J., Russell P., Aken B., Alfoldi J., RA Amemiya C., Azzouzi N., Baroiller J.F., Barloy-Hubler F., Berlin A., RA Bloomquist R., Carleton K.L., Conte M.A., D'Cotta H., Eshel O., RA Gaffney L., Galibert F., Gante H.F., Gnerre S., Greuter L., Guyon R., RA Haddad N.S., Haerty W., Harris R.M., Hofmann H.A., Hourlier T., RA Hulata G., Jaffe D.B., Lara M., Lee A.P., MacCallum I., Mwaiko S., RA Nikaido M., Nishihara H., Ozouf-Costaz C., Penman D.J., Przybylski D., RA Rakotomanga M., Renn S.C.P., Ribeiro F.J., Ron M., Salzburger W., RA Sanchez-Pulido L., Santos M.E., Searle S., Sharpe T., Swofford R., RA Tan F.J., Williams L., Young S., Yin S., Okada N., Kocher T.D., RA Miska E.A., Lander E.S., Venkatesh B., Fernald R.D., Meyer A., RA Ponting C.P., Streelman J.T., Lindblad-Toh K., Seehausen O., RA Di Palma F.; RT "The genomic substrate for adaptive radiation in African cichlid RT fish."; RL Nature 513:375-381(2014). RN [3] {ECO:0000313|Ensembl:ENSNBRP00000005611} RP IDENTIFICATION. RG Ensembl; RL Submitted (JAN-2019) to UniProtKB. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor Fz/Smo CC family. {ECO:0000256|SAAS:SAAS00874568}. CC -!- CAUTION: Lacks conserved residue(s) required for the propagation CC of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00090}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR RefSeq; XP_006780762.1; XM_006780699.1. DR RefSeq; XP_006780763.1; XM_006780700.1. DR Ensembl; ENSNBRT00000005777; ENSNBRP00000005611; ENSNBRG00000004418. DR GeneID; 102780724; -. DR GeneTree; ENSGT00940000157206; -. DR Proteomes; UP000261580; Whole Genome Shotgun Assembly. DR GO; GO:0005929; C:cilium; IEA:Ensembl. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0008142; F:oxysterol binding; IEA:Ensembl. DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro. DR GO; GO:0021984; P:adenohypophysis development; IEA:Ensembl. DR GO; GO:0035479; P:angioblast cell migration from lateral mesoderm to midline; IEA:Ensembl. DR GO; GO:0009952; P:anterior/posterior pattern specification; IEA:Ensembl. DR GO; GO:0060844; P:arterial endothelial cell fate commitment; IEA:Ensembl. DR GO; GO:0003231; P:cardiac ventricle development; IEA:Ensembl. DR GO; GO:0010002; P:cardioblast differentiation; IEA:Ensembl. DR GO; GO:0051216; P:cartilage development; IEA:Ensembl. DR GO; GO:0035143; P:caudal fin morphogenesis; IEA:Ensembl. DR GO; GO:0021587; P:cerebellum morphogenesis; IEA:Ensembl. DR GO; GO:0060830; P:ciliary receptor clustering involved in smoothened signaling pathway; IEA:Ensembl. DR GO; GO:0071679; P:commissural neuron axon guidance; IEA:Ensembl. DR GO; GO:0035912; P:dorsal aorta morphogenesis; IEA:Ensembl. DR GO; GO:0031076; P:embryonic camera-type eye development; IEA:Ensembl. DR GO; GO:0048557; P:embryonic digestive tract morphogenesis; IEA:Ensembl. DR GO; GO:0048702; P:embryonic neurocranium morphogenesis; IEA:Ensembl. DR GO; GO:0009880; P:embryonic pattern specification; IEA:Ensembl. DR GO; GO:0048703; P:embryonic viscerocranium morphogenesis; IEA:Ensembl. DR GO; GO:0060956; P:endocardial cell differentiation; IEA:Ensembl. DR GO; GO:0031018; P:endocrine pancreas development; IEA:Ensembl. DR GO; GO:0072175; P:epithelial tube formation; IEA:Ensembl. DR GO; GO:0031017; P:exocrine pancreas development; IEA:Ensembl. DR GO; GO:0021508; P:floor plate formation; IEA:Ensembl. DR GO; GO:0021798; P:forebrain dorsal/ventral pattern formation; IEA:Ensembl. DR GO; GO:0021986; P:habenula development; IEA:Ensembl. DR GO; GO:0001947; P:heart looping; IEA:Ensembl. DR GO; GO:0042693; P:muscle cell fate commitment; IEA:Ensembl. DR GO; GO:0030239; P:myofibril assembly; IEA:Ensembl. DR GO; GO:0014033; P:neural crest cell differentiation; IEA:Ensembl. DR GO; GO:0001839; P:neural plate morphogenesis; IEA:Ensembl. DR GO; GO:0060896; P:neural plate pattern specification; IEA:Ensembl. DR GO; GO:0014003; P:oligodendrocyte development; IEA:Ensembl. DR GO; GO:0032474; P:otolith morphogenesis; IEA:Ensembl. DR GO; GO:0045880; P:positive regulation of smoothened signaling pathway; IEA:Ensembl. DR GO; GO:0060041; P:retina development in camera-type eye; IEA:Ensembl. DR GO; GO:0031290; P:retinal ganglion cell axon guidance; IEA:Ensembl. DR GO; GO:0048752; P:semicircular canal morphogenesis; IEA:Ensembl. DR GO; GO:0048741; P:skeletal muscle fiber development; IEA:Ensembl. DR GO; GO:0048745; P:smooth muscle tissue development; IEA:Ensembl. DR GO; GO:0021523; P:somatic motor neuron differentiation; IEA:Ensembl. DR GO; GO:0061053; P:somite development; IEA:Ensembl. DR GO; GO:0021520; P:spinal cord motor neuron cell fate specification; IEA:Ensembl. DR GO; GO:0048795; P:swim bladder morphogenesis; IEA:Ensembl. DR GO; GO:0021537; P:telencephalon development; IEA:Ensembl. DR GO; GO:0001570; P:vasculogenesis; IEA:Ensembl. DR CDD; cd07451; CRD_SMO; 1. DR Gene3D; 1.10.2000.10; -; 1. DR InterPro; IPR015526; Frizzled/SFRP. DR InterPro; IPR000539; Frizzled/Smoothened_TM. DR InterPro; IPR020067; Frizzled_dom. DR InterPro; IPR036790; Frizzled_dom_sf. DR InterPro; IPR017981; GPCR_2-like. DR InterPro; IPR026544; SMO. DR InterPro; IPR041771; SMO_CRD. DR PANTHER; PTHR11309; PTHR11309; 1. DR PANTHER; PTHR11309:SF35; PTHR11309:SF35; 1. DR Pfam; PF01534; Frizzled; 1. DR Pfam; PF01392; Fz; 1. DR PRINTS; PR00489; FRIZZLED. DR SMART; SM00063; FRI; 1. DR SMART; SM01330; Frizzled; 1. DR SUPFAM; SSF63501; SSF63501; 1. DR PROSITE; PS50038; FZ; 1. DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000261580}; KW Developmental protein {ECO:0000256|SAAS:SAAS00427069}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00978052}; KW Membrane {ECO:0000256|SAAS:SAAS00874221, ECO:0000256|SAM:Phobius}; KW Receptor {ECO:0000256|SAAS:SAAS00874335}; KW Reference proteome {ECO:0000313|Proteomes:UP000261580}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00874792, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00874766, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 28 {ECO:0000256|SAM:SignalP}. FT CHAIN 29 825 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5018714969. FT TRANSMEM 208 229 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 241 258 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 290 314 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 334 354 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 374 395 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 427 450 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 497 520 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 42 156 FZ. {ECO:0000259|PROSITE:PS50038}. FT DOMAIN 205 468 G_PROTEIN_RECEP_F2_4. FT {ECO:0000259|PROSITE:PS50261}. SQ SEQUENCE 825 AA; 93230 MW; AEB9FB5FF4E70286 CRC64; MSSKSWSPIV GFYGMLCVWA AWLSGCGAVL SPNGTIFEDT CKKTSTCEVL KYNTCLGSPL PYTHTSLILA EDSSTQEEAF EKLTMWSGLR NAPRCWSVIQ PLLCAVYMPK CENGRVELPS QSLCLTTRSP CSIVDRERGW PSFLKCDKFP VGCSNEVQKL KFNTSGQCEA PLVKTDIQSS WYKDVEGCGI QCDNPLFTEE EHNDMHAYIA YFGTITLLCT FFTLATFLAD WKNSNRYPAV ILFYINACFF VGSIGWLAQF LDGAREEIVC KSDNTMRLGE PSSSETLSCV TIFIIVYYSL MSGVIWFVML TYAWHTSFKA LGTTHQPLSG RTSYFHMVTW SIPFVLTVAI LAIAEVDGDS VSGICFVGYK NYRYRAGFVL APIGVVLVVG GYFLIRGVMT LFSIKSNHPG LLSEKAASKI NETMLRLGIF GFLAFGFVFI TFGCHFYDFF NQAEWERSFR DYVLCEANVT IASQTNKPIP ECTIKNRPSL MVEKINLFSM FGTGIAMSTW VWTKATILIW KRTWCKIIGR SDNEPKRIKK SKMIAKAFAM RKELHKDPEK ELSFSMHTVS HEGPVAGINF DLNEPSNDMS SAWAQHVTKM VARRGAILPQ DISVTPTGTP VPPPEERNRL WMVEAEISPE MIKRKKKKKK RKKEVRPVEE MVDHQVYRQR EFGRSSVPRL PKLPPHPSLV ANLREQQRQQ QKIEEEVLPG SYPDFQPSRR LSCEEKCPYL QYQTSQNGYG HSMLSDPLTF RDRPEDLGLG PRYPPSNWQP SASSRYPGNM DITDGISERM AHVARVPAGR RAGYGPIHSR TNLMEAELMD ADSDF //