ID   A0A3Q4GAV3_NEOBR        Unreviewed;       825 AA.
AC   A0A3Q4GAV3;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   08-MAY-2019, entry version 2.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSNBRP00000005611};
OS   Neolamprologus brichardi (Fairy cichlid) (Lamprologus brichardi).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Lamprologini; Neolamprologus.
OX   NCBI_TaxID=32507 {ECO:0000313|Ensembl:ENSNBRP00000005611};
RN   [1] {ECO:0000313|Ensembl:ENSNBRP00000005611}
RP   NUCLEOTIDE SEQUENCE.
RA   Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA   MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RL   Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSNBRP00000005611}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=25186727; DOI=10.1038/nature13726;
RA   Brawand D., Wagner C.E., Li Y.I., Malinsky M., Keller I., Fan S.,
RA   Simakov O., Ng A.Y., Lim Z.W., Bezault E., Turner-Maier J.,
RA   Johnson J., Alcazar R., Noh H.J., Russell P., Aken B., Alfoldi J.,
RA   Amemiya C., Azzouzi N., Baroiller J.F., Barloy-Hubler F., Berlin A.,
RA   Bloomquist R., Carleton K.L., Conte M.A., D'Cotta H., Eshel O.,
RA   Gaffney L., Galibert F., Gante H.F., Gnerre S., Greuter L., Guyon R.,
RA   Haddad N.S., Haerty W., Harris R.M., Hofmann H.A., Hourlier T.,
RA   Hulata G., Jaffe D.B., Lara M., Lee A.P., MacCallum I., Mwaiko S.,
RA   Nikaido M., Nishihara H., Ozouf-Costaz C., Penman D.J., Przybylski D.,
RA   Rakotomanga M., Renn S.C.P., Ribeiro F.J., Ron M., Salzburger W.,
RA   Sanchez-Pulido L., Santos M.E., Searle S., Sharpe T., Swofford R.,
RA   Tan F.J., Williams L., Young S., Yin S., Okada N., Kocher T.D.,
RA   Miska E.A., Lander E.S., Venkatesh B., Fernald R.D., Meyer A.,
RA   Ponting C.P., Streelman J.T., Lindblad-Toh K., Seehausen O.,
RA   Di Palma F.;
RT   "The genomic substrate for adaptive radiation in African cichlid
RT   fish.";
RL   Nature 513:375-381(2014).
RN   [3] {ECO:0000313|Ensembl:ENSNBRP00000005611}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JAN-2019) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor Fz/Smo
CC       family. {ECO:0000256|SAAS:SAAS00874568}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00090}.
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DR   RefSeq; XP_006780762.1; XM_006780699.1.
DR   RefSeq; XP_006780763.1; XM_006780700.1.
DR   Ensembl; ENSNBRT00000005777; ENSNBRP00000005611; ENSNBRG00000004418.
DR   GeneID; 102780724; -.
DR   GeneTree; ENSGT00940000157206; -.
DR   CDD; cd15030; 7tmF_SMO_homolog; 1.
DR   CDD; cd07451; CRD_SMO; 1.
DR   Gene3D; 1.10.2000.10; -; 1.
DR   InterPro; IPR015526; Frizzled/SFRP.
DR   InterPro; IPR000539; Frizzled/Smoothened_TM.
DR   InterPro; IPR020067; Frizzled_dom.
DR   InterPro; IPR036790; Frizzled_dom_sf.
DR   InterPro; IPR017981; GPCR_2-like.
DR   InterPro; IPR026544; SMO.
DR   InterPro; IPR035683; SMO_7TM.
DR   InterPro; IPR041771; SMO_CRD.
DR   PANTHER; PTHR11309; PTHR11309; 1.
DR   PANTHER; PTHR11309:SF35; PTHR11309:SF35; 1.
DR   Pfam; PF01534; Frizzled; 1.
DR   Pfam; PF01392; Fz; 1.
DR   PRINTS; PR00489; FRIZZLED.
DR   SMART; SM00063; FRI; 1.
DR   SMART; SM01330; Frizzled; 1.
DR   SUPFAM; SSF63501; SSF63501; 1.
DR   PROSITE; PS50038; FZ; 1.
DR   PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
PE   3: Inferred from homology;
KW   Developmental protein {ECO:0000256|SAAS:SAAS00427069};
KW   Disulfide bond {ECO:0000256|SAAS:SAAS00978052};
KW   Membrane {ECO:0000256|SAAS:SAAS00874221, ECO:0000256|SAM:Phobius};
KW   Receptor {ECO:0000256|SAAS:SAAS00874335};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00874792,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00874766,
KW   ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     28       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        29    825       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5018714969.
FT   TRANSMEM    208    229       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    241    258       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    290    314       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    334    354       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    374    395       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    427    450       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    497    520       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       42    156       FZ. {ECO:0000259|PROSITE:PS50038}.
FT   DOMAIN      205    468       G_PROTEIN_RECEP_F2_4.
FT                                {ECO:0000259|PROSITE:PS50261}.
SQ   SEQUENCE   825 AA;  93230 MW;  AEB9FB5FF4E70286 CRC64;
     MSSKSWSPIV GFYGMLCVWA AWLSGCGAVL SPNGTIFEDT CKKTSTCEVL KYNTCLGSPL
     PYTHTSLILA EDSSTQEEAF EKLTMWSGLR NAPRCWSVIQ PLLCAVYMPK CENGRVELPS
     QSLCLTTRSP CSIVDRERGW PSFLKCDKFP VGCSNEVQKL KFNTSGQCEA PLVKTDIQSS
     WYKDVEGCGI QCDNPLFTEE EHNDMHAYIA YFGTITLLCT FFTLATFLAD WKNSNRYPAV
     ILFYINACFF VGSIGWLAQF LDGAREEIVC KSDNTMRLGE PSSSETLSCV TIFIIVYYSL
     MSGVIWFVML TYAWHTSFKA LGTTHQPLSG RTSYFHMVTW SIPFVLTVAI LAIAEVDGDS
     VSGICFVGYK NYRYRAGFVL APIGVVLVVG GYFLIRGVMT LFSIKSNHPG LLSEKAASKI
     NETMLRLGIF GFLAFGFVFI TFGCHFYDFF NQAEWERSFR DYVLCEANVT IASQTNKPIP
     ECTIKNRPSL MVEKINLFSM FGTGIAMSTW VWTKATILIW KRTWCKIIGR SDNEPKRIKK
     SKMIAKAFAM RKELHKDPEK ELSFSMHTVS HEGPVAGINF DLNEPSNDMS SAWAQHVTKM
     VARRGAILPQ DISVTPTGTP VPPPEERNRL WMVEAEISPE MIKRKKKKKK RKKEVRPVEE
     MVDHQVYRQR EFGRSSVPRL PKLPPHPSLV ANLREQQRQQ QKIEEEVLPG SYPDFQPSRR
     LSCEEKCPYL QYQTSQNGYG HSMLSDPLTF RDRPEDLGLG PRYPPSNWQP SASSRYPGNM
     DITDGISERM AHVARVPAGR RAGYGPIHSR TNLMEAELMD ADSDF
//