ID   A0A3Q2UIM7_CHICK        Unreviewed;      1153 AA.
AC   A0A3Q2UIM7;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   08-MAY-2019, entry version 2.
DE   RecName: Full=Alpha-mannosidase {ECO:0000256|RuleBase:RU361199};
DE            EC=3.2.1.- {ECO:0000256|RuleBase:RU361199};
GN   Name=MAN2A1 {ECO:0000313|Ensembl:ENSGALP00000074207};
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes;
OC   Phasianidae; Phasianinae; Gallus.
OX   NCBI_TaxID=9031 {ECO:0000313|Ensembl:ENSGALP00000074207, ECO:0000313|Proteomes:UP000000539};
RN   [1] {ECO:0000313|Ensembl:ENSGALP00000074207, ECO:0000313|Proteomes:UP000000539}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Red jungle fowl {ECO:0000313|Ensembl:ENSGALP00000074207,
RC   ECO:0000313|Proteomes:UP000000539};
RX   PubMed=15592404; DOI=10.1038/nature03154;
RG   International Chicken Genome Sequencing Consortium;
RA   Hillier L.W., Miller W., Birney E., Warren W., Hardison R.C.,
RA   Ponting C.P., Bork P., Burt D.W., Groenen M.A.M., Delany M.E.,
RA   Dodgson J.B., Chinwalla A.T., Cliften P.F., Clifton S.W.,
RA   Delehaunty K.D., Fronick C., Fulton R.S., Graves T.A., Kremitzki C.,
RA   Layman D., Magrini V., McPherson J.D., Miner T.L., Minx P., Nash W.E.,
RA   Nhan M.N., Nelson J.O., Oddy L.G., Pohl C.S., Randall-Maher J.,
RA   Smith S.M., Wallis J.W., Yang S.-P., Romanov M.N., Rondelli C.M.,
RA   Paton B., Smith J., Morrice D., Daniels L., Tempest H.G.,
RA   Robertson L., Masabanda J.S., Griffin D.K., Vignal A., Fillon V.,
RA   Jacobbson L., Kerje S., Andersson L., Crooijmans R.P., Aerts J.,
RA   van der Poel J.J., Ellegren H., Caldwell R.B., Hubbard S.J.,
RA   Grafham D.V., Kierzek A.M., McLaren S.R., Overton I.M., Arakawa H.,
RA   Beattie K.J., Bezzubov Y., Boardman P.E., Bonfield J.K.,
RA   Croning M.D.R., Davies R.M., Francis M.D., Humphray S.J., Scott C.E.,
RA   Taylor R.G., Tickle C., Brown W.R.A., Rogers J., Buerstedde J.-M.,
RA   Wilson S.A., Stubbs L., Ovcharenko I., Gordon L., Lucas S.,
RA   Miller M.M., Inoko H., Shiina T., Kaufman J., Salomonsen J.,
RA   Skjoedt K., Wong G.K.-S., Wang J., Liu B., Wang J., Yu J., Yang H.,
RA   Nefedov M., Koriabine M., Dejong P.J., Goodstadt L., Webber C.,
RA   Dickens N.J., Letunic I., Suyama M., Torrents D., von Mering C.,
RA   Zdobnov E.M., Makova K., Nekrutenko A., Elnitski L., Eswara P.,
RA   King D.C., Yang S.-P., Tyekucheva S., Radakrishnan A., Harris R.S.,
RA   Chiaromonte F., Taylor J., He J., Rijnkels M., Griffiths-Jones S.,
RA   Ureta-Vidal A., Hoffman M.M., Severin J., Searle S.M.J., Law A.S.,
RA   Speed D., Waddington D., Cheng Z., Tuzun E., Eichler E., Bao Z.,
RA   Flicek P., Shteynberg D.D., Brent M.R., Bye J.M., Huckle E.J.,
RA   Chatterji S., Dewey C., Pachter L., Kouranov A., Mourelatos Z.,
RA   Hatzigeorgiou A.G., Paterson A.H., Ivarie R., Brandstrom M.,
RA   Axelsson E., Backstrom N., Berlin S., Webster M.T., Pourquie O.,
RA   Reymond A., Ucla C., Antonarakis S.E., Long M., Emerson J.J.,
RA   Betran E., Dupanloup I., Kaessmann H., Hinrichs A.S., Bejerano G.,
RA   Furey T.S., Harte R.A., Raney B., Siepel A., Kent W.J., Haussler D.,
RA   Eyras E., Castelo R., Abril J.F., Castellano S., Camara F., Parra G.,
RA   Guigo R., Bourque G., Tesler G., Pevzner P.A., Smit A., Fulton L.A.,
RA   Mardis E.R., Wilson R.K.;
RT   "Sequence and comparative analysis of the chicken genome provide
RT   unique perspectives on vertebrate evolution.";
RL   Nature 432:695-716(2004).
RN   [2] {ECO:0000313|Ensembl:ENSGALP00000074207}
RP   IDENTIFICATION.
RC   STRAIN=Red jungle fowl {ECO:0000313|Ensembl:ENSGALP00000074207};
RG   Ensembl;
RL   Submitted (JAN-2019) to UniProtKB.
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|RuleBase:RU361199};
CC       Note=Binds 1 zinc ion per subunit.
CC       {ECO:0000256|RuleBase:RU361199};
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 38 family.
CC       {ECO:0000256|RuleBase:RU361199}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AC187116; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC193561; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_003643094.1; XM_003643046.3.
DR   Ensembl; ENSGALT00000100341; ENSGALP00000074207; ENSGALG00000000255.
DR   GeneID; 415611; -.
DR   GeneTree; ENSGT00950000182799; -.
DR   Proteomes; UP000000539; Chromosome Z.
DR   Gene3D; 1.20.1270.50; -; 1.
DR   Gene3D; 2.60.40.1180; -; 1.
DR   Gene3D; 3.20.110.10; -; 1.
DR   InterPro; IPR011013; Gal_mutarotase_sf_dom.
DR   InterPro; IPR011330; Glyco_hydro/deAcase_b/a-brl.
DR   InterPro; IPR011682; Glyco_hydro_38_C.
DR   InterPro; IPR015341; Glyco_hydro_38_cen.
DR   InterPro; IPR037094; Glyco_hydro_38_cen_sf.
DR   InterPro; IPR000602; Glyco_hydro_38_N.
DR   InterPro; IPR027291; Glyco_hydro_38_N_sf.
DR   InterPro; IPR028995; Glyco_hydro_57/38_cen_sf.
DR   InterPro; IPR013780; Glyco_hydro_b.
DR   Pfam; PF09261; Alpha-mann_mid; 1.
DR   Pfam; PF07748; Glyco_hydro_38C; 1.
DR   Pfam; PF01074; Glyco_hydro_38N; 1.
DR   SMART; SM00872; Alpha-mann_mid; 1.
DR   SUPFAM; SSF74650; SSF74650; 1.
DR   SUPFAM; SSF88688; SSF88688; 1.
DR   SUPFAM; SSF88713; SSF88713; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000000539};
KW   Glycosidase {ECO:0000256|RuleBase:RU361199};
KW   Hydrolase {ECO:0000256|RuleBase:RU361199};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Metal-binding {ECO:0000256|RuleBase:RU361199};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000539};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Zinc {ECO:0000256|RuleBase:RU361199}.
FT   TRANSMEM      7     26       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      504    591       Alpha-mann_mid. {ECO:0000259|SMART:
FT                                SM00872}.
FT   COILED       48     68       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1153 AA;  131995 MW;  9D925BF6EF83051C CRC64;
     MKLSRQFTVL GSAVFCVVIF SLYLMLDRGH FDHPKSPRRE GTFPKGQLSI LQEKIDHLER
     LLAENNEIIS NIRDSVINLS ESVKDGQKNP VTINFSQGSQ LDLFRSAPTL LSVDSEDCLF
     ASKSGSHSSD VQMLDVYDIL PFDNPDGGVW KQGFDITYNE NEWDSAPLQV FVVPHSHNDP
     GWLKTFDDYF RDQTQHILNN MVIKLQEDNR RKFIWSEISY FSKWWDGIDS QRRDAVKRLI
     KDGQFEIVTG GWVMPDEASA HYFSLIDQLI EGHQWLERNL GVKPKSGWAV DPFGHSPTMA
     YLLKRAGFSN MLIQRIHYSV KKYFSAQKTL EFFWRQNWDL GSSTDILCHM MPFYSYDVPH
     TCGPDPKICC QFDFKRLPGG RVSCPWRVPP EAIHSGNIQH RAWMILDQYR KKSKLFRTKV
     LLAPLGDDFR YAESSEWDQQ YQNYQKLFDY MNTHPEFHVK AQFGTLSDYF EALRKESNLG
     EGSSSPLFPV LSGDFFTYAD RDHHYWSGYF TSRPFYKRLD RVLESHLRAA EILYSLALIQ
     SHKYNKMSVF PSVDNYKLLT EARRNLGLFQ HHDAITGTSK DWVVVDYGTR LFHSLMNVKK
     VIIDSAHILI LKDKGAYNYD TSTPFLKMDD VQSSQDSLPH KTVIKLTSQP RYLLIHNPTD
     QERFSVVSVI VSSPRVKLLS PLGKPVTVQI SAVWDGATTV SHEAYQVSFL AHLPPLGLGV
     YQLLEVPSSE ANLAEYNIYM SGRDSVQEKS DRIFKIKEMQ NSVDNIILEN SYMKLWFSGT
     SGLLEKINTK EDGKNHQMKV EFAWYGTTSN RDKSGAYLFL PDGDAKPYIF TDPPTVRVAH
     GKIFSEVVCF FHHVTHTMRL YNVQGLEGQS LEVSNIVDIR GEYNRELAMR ISSDINSRNR
     FYVDLNGYQI QPRLTMSKLP LQANIYPMTT MAYIQDSGVR LTLHSAQSLG VASLKNGQLE
     VIMDRRLMQD DNRGLGQGVQ DNKITANVFR LLLERRHGTD VNEEKASVSF PSLLSHMTSS
     FLNHPVIPMT TNADSGVPEM LNMFSPLMSS MPCDIHIVNL RTIQSKVDTE PSDEAALILH
     RKGFDCRFSN RDVGLLCSTT QGKVRVHKLF NKFSVESLTP ASLSLMHSPP DARNMSEINM
     SSMEINTFRI RLR
//