ID   A0A3Q2UFC3_CHICK        Unreviewed;      1385 AA.
AC   A0A3Q2UFC3;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   19-JAN-2022, entry version 11.
DE   RecName: Full=Anion exchange protein {ECO:0000256|RuleBase:RU362035};
GN   Name=SLC4A2 {ECO:0000313|Ensembl:ENSGALP00000073040};
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031 {ECO:0000313|Ensembl:ENSGALP00000073040, ECO:0000313|Proteomes:UP000000539};
RN   [1] {ECO:0000313|Ensembl:ENSGALP00000073040, ECO:0000313|Proteomes:UP000000539}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Red jungle fowl {ECO:0000313|Ensembl:ENSGALP00000073040,
RC   ECO:0000313|Proteomes:UP000000539};
RX   PubMed=15592404; DOI=10.1038/nature03154;
RG   International Chicken Genome Sequencing Consortium;
RA   Hillier L.W., Miller W., Birney E., Warren W., Hardison R.C., Ponting C.P.,
RA   Bork P., Burt D.W., Groenen M.A.M., Delany M.E., Dodgson J.B.,
RA   Chinwalla A.T., Cliften P.F., Clifton S.W., Delehaunty K.D., Fronick C.,
RA   Fulton R.S., Graves T.A., Kremitzki C., Layman D., Magrini V.,
RA   McPherson J.D., Miner T.L., Minx P., Nash W.E., Nhan M.N., Nelson J.O.,
RA   Oddy L.G., Pohl C.S., Randall-Maher J., Smith S.M., Wallis J.W.,
RA   Yang S.-P., Romanov M.N., Rondelli C.M., Paton B., Smith J., Morrice D.,
RA   Daniels L., Tempest H.G., Robertson L., Masabanda J.S., Griffin D.K.,
RA   Vignal A., Fillon V., Jacobbson L., Kerje S., Andersson L.,
RA   Crooijmans R.P., Aerts J., van der Poel J.J., Ellegren H., Caldwell R.B.,
RA   Hubbard S.J., Grafham D.V., Kierzek A.M., McLaren S.R., Overton I.M.,
RA   Arakawa H., Beattie K.J., Bezzubov Y., Boardman P.E., Bonfield J.K.,
RA   Croning M.D.R., Davies R.M., Francis M.D., Humphray S.J., Scott C.E.,
RA   Taylor R.G., Tickle C., Brown W.R.A., Rogers J., Buerstedde J.-M.,
RA   Wilson S.A., Stubbs L., Ovcharenko I., Gordon L., Lucas S., Miller M.M.,
RA   Inoko H., Shiina T., Kaufman J., Salomonsen J., Skjoedt K., Wong G.K.-S.,
RA   Wang J., Liu B., Wang J., Yu J., Yang H., Nefedov M., Koriabine M.,
RA   Dejong P.J., Goodstadt L., Webber C., Dickens N.J., Letunic I., Suyama M.,
RA   Torrents D., von Mering C., Zdobnov E.M., Makova K., Nekrutenko A.,
RA   Elnitski L., Eswara P., King D.C., Yang S.-P., Tyekucheva S.,
RA   Radakrishnan A., Harris R.S., Chiaromonte F., Taylor J., He J.,
RA   Rijnkels M., Griffiths-Jones S., Ureta-Vidal A., Hoffman M.M., Severin J.,
RA   Searle S.M.J., Law A.S., Speed D., Waddington D., Cheng Z., Tuzun E.,
RA   Eichler E., Bao Z., Flicek P., Shteynberg D.D., Brent M.R., Bye J.M.,
RA   Huckle E.J., Chatterji S., Dewey C., Pachter L., Kouranov A.,
RA   Mourelatos Z., Hatzigeorgiou A.G., Paterson A.H., Ivarie R., Brandstrom M.,
RA   Axelsson E., Backstrom N., Berlin S., Webster M.T., Pourquie O.,
RA   Reymond A., Ucla C., Antonarakis S.E., Long M., Emerson J.J., Betran E.,
RA   Dupanloup I., Kaessmann H., Hinrichs A.S., Bejerano G., Furey T.S.,
RA   Harte R.A., Raney B., Siepel A., Kent W.J., Haussler D., Eyras E.,
RA   Castelo R., Abril J.F., Castellano S., Camara F., Parra G., Guigo R.,
RA   Bourque G., Tesler G., Pevzner P.A., Smit A., Fulton L.A., Mardis E.R.,
RA   Wilson R.K.;
RT   "Sequence and comparative analysis of the chicken genome provide unique
RT   perspectives on vertebrate evolution.";
RL   Nature 432:695-716(2004).
RN   [2] {ECO:0000313|Ensembl:ENSGALP00000073040}
RP   IDENTIFICATION.
RC   STRAIN=Red jungle fowl {ECO:0000313|Ensembl:ENSGALP00000073040};
RG   Ensembl;
RL   Submitted (JAN-2019) to UniProtKB.
CC   -!- FUNCTION: Plasma membrane anion exchange protein of wide distribution.
CC       {ECO:0000256|ARBA:ARBA00002282}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC       ECO:0000256|RuleBase:RU362035}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU362035}.
CC   -!- SIMILARITY: Belongs to the anion exchanger (TC 2.A.31) family.
CC       {ECO:0000256|ARBA:ARBA00010993, ECO:0000256|RuleBase:RU362035}.
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DR   EMBL; AADN05000033; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 9031.ENSGALP00000041970; -.
DR   Ensembl; ENSGALT00000105142; ENSGALP00000073040; ENSGALG00000034284.
DR   GeneTree; ENSGT00940000158259; -.
DR   Proteomes; UP000000539; Chromosome 2.
DR   ExpressionAtlas; A0A3Q2UFC3; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0015301; F:anion:anion antiporter activity; IEA:UniProtKB-KW.
DR   GO; GO:0005452; F:inorganic anion exchanger activity; IEA:InterPro.
DR   Gene3D; 3.40.930.10; -; 1.
DR   InterPro; IPR001717; Anion_exchange.
DR   InterPro; IPR002978; Anion_exchange_2.
DR   InterPro; IPR018241; Anion_exchange_CS.
DR   InterPro; IPR013769; Band3_cytoplasmic_dom.
DR   InterPro; IPR011531; HCO3_transpt_C.
DR   InterPro; IPR003020; HCO3_transpt_euk.
DR   InterPro; IPR016152; PTrfase/Anion_transptr.
DR   PANTHER; PTHR11453; PTHR11453; 1.
DR   PANTHER; PTHR11453:SF14; PTHR11453:SF14; 1.
DR   Pfam; PF07565; Band_3_cyto; 1.
DR   Pfam; PF00955; HCO3_cotransp; 1.
DR   PRINTS; PR00165; ANIONEXCHNGR.
DR   PRINTS; PR01231; HCO3TRNSPORT.
DR   SUPFAM; SSF55804; SSF55804; 1.
DR   TIGRFAMs; TIGR00834; ae; 1.
DR   PROSITE; PS00219; ANION_EXCHANGER_1; 1.
DR   PROSITE; PS00220; ANION_EXCHANGER_2; 1.
PE   3: Inferred from homology;
KW   Anion exchange {ECO:0000256|ARBA:ARBA00022681};
KW   Antiport {ECO:0000256|ARBA:ARBA00022449};
KW   Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW   ECO:0000256|RuleBase:RU362035};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362035};
KW   Methylation {ECO:0000256|ARBA:ARBA00022481};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000539};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU362035};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU362035};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU362035}.
FT   TRANSMEM        750..771
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362035"
FT   TRANSMEM        792..815
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362035"
FT   TRANSMEM        835..860
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362035"
FT   TRANSMEM        867..885
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362035"
FT   TRANSMEM        929..946
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362035"
FT   TRANSMEM        962..982
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362035"
FT   TRANSMEM        1019..1038
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362035"
FT   TRANSMEM        1059..1083
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362035"
FT   TRANSMEM        1119..1138
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362035"
FT   TRANSMEM        1145..1164
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362035"
FT   TRANSMEM        1197..1225
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362035"
FT   DOMAIN          391..664
FT                   /note="Band_3_cyto"
FT                   /evidence="ECO:0000259|Pfam:PF07565"
FT   DOMAIN          721..1196
FT                   /note="HCO3_cotransp"
FT                   /evidence="ECO:0000259|Pfam:PF00955"
FT   REGION          1..274
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          335..358
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          519..543
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1255..1281
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1295..1385
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        33..82
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        226..240
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        337..358
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1385 AA;  151602 MW;  F5685134E30BBDD4 CRC64;
     MSRSPVSSEL HHIVSSAIES PEPPAPGPAS PPLAEEEEKD LNKALGVERF EEILSDAHPR
     SVEEPGRIYG EEDFEYHRQS SLHIHHPLSA HLPPDARRKK GVPKKGRKKR GRAAAPGENP
     PIEEGEEDEE EACDTETERS GRGAAGRPRR GGAGRGGAGR GAVPGRATPL GAVLPAGGRG
     DRAPCGGAPG PPGAARPHGG APRSHGPRGS QVSGAAPGVR AGAVRDGRAP RCHRCVRCSP
     GAEEGRAADG GAVPEDGGSP GRPAGRAQPG HRSYNLHERR RIGSMTGAEQ AQYQKVPTDE
     SEAQTLASAD LDYMKSHRFE DVPGVRRHLV RKSAKAQVVH VGKEHREQSA RPRRSDRQPH
     EVFVELNELV LDKNQELQWK ETARWIKFEE DVEEETDRWG KPHVASLSFR SLLELRKTLS
     HGAVLLDLDQ KTLPGVAHQV VEQMVITDQI RAEDRANVLR ALLLKHSHPS DEKEFSFPRN
     ISAGSLGSLL VHHHSTNHVG EGGEPAVTEP LIAGHGAEHD ARVDVERERE VPTPAPPAGI
     TRSKSKHELK LLEKIPDNAE ATVVLVGCVE FLDQPTMAFV RLQEAVELDS VLEVPVPVRF
     LFVLLGPSST HMDYHEIGRS ISTLMSDKQF HEAAYLADDR HDLLTAINEF LDCSVVLPPS
     EVQGEELLRS VAHFQREMLK KREEQEKRML LEPKSPEEKA LLKLKVAEDE DEDDPLRRTG
     RPFGGLIRDV RRRYPHYLSD FRDALNPQCI AAVIFIYFAA LSPAITFGGL LGEKTQDLIG
     VSELIISTSL QGVLFCLLGA QPLLVIGFSG PLLVFEEAFF TFCTSNGLEY LVGRVWIGFW
     LILIVLLMVA CEGSFLVRFV SRFTQEIFAF LISLIFIYET FSKLGKIFQE HPLHGCAQPN
     GTTWSNGTAA PNGTAQRGAA KVTGQPNTAL LSLVLMAGTF FIAFFLRKFK NSRFFPGRIR
     RLIGDFGVPI AILVMVLVDY SIRDTYTQKL SVPSGFSVTA PDKRGWVINP LGERSDFPVW
     MMVASGLPAV LVFILIFMET QITTLIISKK ERMLQKGSGF HLDLLLIVAM GGFFALFGLP
     WLAAATVRSV THANALTVMS KAVAPGDKPK IQEVKEQRVT GLLVAVLVGL SIVIGELLRQ
     IPLAVLFGIF LYMGVTSLNG IQFYERLQLL LMPPKHHPDV PYVKKVRTLR MHLFTGLQLA
     CLAVLWAVMS TVASLAFPFI LILTVPLRMC LLSRIFTDRE MKCVSTRPAL GGAMGAAPAA
     AHPVPPSWMR TRRSPSWTSG KAWMSTTRCR CRCEPRRQAA RRAQPGPPAR PPPDTPRLRG
     SAGETPPRSR PPLASAAVGG PLGHVLTAPR GGAPSRSPAA PQVCALPRPR APARRSAVPP
     EPRFY
//