ID A0A3Q2I8F7_HORSE Unreviewed; 714 AA. AC A0A3Q2I8F7; DT 10-APR-2019, integrated into UniProtKB/TrEMBL. DT 13-SEP-2023, sequence version 2. DT 24-JAN-2024, entry version 22. DE SubName: Full=Dachshund family transcription factor 1 {ECO:0000313|Ensembl:ENSECAP00000044280.2}; GN Name=DACH1 {ECO:0000313|Ensembl:ENSECAP00000044280.2, GN ECO:0000313|VGNC:VGNC:16996}; OS Equus caballus (Horse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus. OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000044280.2, ECO:0000313|Proteomes:UP000002281}; RN [1] {ECO:0000313|Ensembl:ENSECAP00000044280.2, ECO:0000313|Proteomes:UP000002281} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000044280.2, RC ECO:0000313|Proteomes:UP000002281}; RX PubMed=19892987; DOI=10.1126/science.1178158; RG Broad Institute Genome Sequencing Platform; RG Broad Institute Whole Genome Assembly Team; RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F., RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O., RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T., RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T., RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S., RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G., RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R., RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A., RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J., RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.; RT "Genome sequence, comparative analysis, and population genetics of the RT domestic horse."; RL Science 326:865-867(2009). RN [2] {ECO:0000313|Ensembl:ENSECAP00000044280.2} RP IDENTIFICATION. RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000044280.2}; RG Ensembl; RL Submitted (JUL-2023) to UniProtKB. CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}. CC -!- SIMILARITY: Belongs to the DACH/dachshund family. CC {ECO:0000256|ARBA:ARBA00038192}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR STRING; 9796.ENSECAP00000044280; -. DR PaxDb; 9796-ENSECAP00000044280; -. DR Ensembl; ENSECAT00000063439.2; ENSECAP00000044280.2; ENSECAG00000017699.4. DR VGNC; VGNC:16996; DACH1. DR GeneTree; ENSGT00390000001134; -. DR InParanoid; A0A3Q2I8F7; -. DR OMA; DMGHEAK; -. DR Proteomes; UP000002281; Chromosome 17. DR Bgee; ENSECAG00000017699; Expressed in brainstem and 23 other cell types or tissues. DR GO; GO:0005829; C:cytosol; IEA:Ensembl. DR GO; GO:0005794; C:Golgi apparatus; IEA:Ensembl. DR GO; GO:0016607; C:nuclear speck; IEA:Ensembl. DR GO; GO:0005634; C:nucleus; IBA:GO_Central. DR GO; GO:0005667; C:transcription regulator complex; IBA:GO_Central. DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central. DR GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; IEA:Ensembl. DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central. DR GO; GO:0046545; P:development of primary female sexual characteristics; IEA:Ensembl. DR GO; GO:0030336; P:negative regulation of cell migration; IEA:Ensembl. DR GO; GO:0060244; P:negative regulation of cell proliferation involved in contact inhibition; IEA:Ensembl. DR GO; GO:2000279; P:negative regulation of DNA biosynthetic process; IEA:Ensembl. DR GO; GO:0048147; P:negative regulation of fibroblast proliferation; IEA:Ensembl. DR GO; GO:0010944; P:negative regulation of transcription by competitive promoter binding; IEA:Ensembl. DR GO; GO:0033262; P:regulation of nuclear cell cycle DNA replication; IEA:Ensembl. DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central. DR GO; GO:0007585; P:respiratory gaseous exchange by respiratory system; IEA:Ensembl. DR GO; GO:0001967; P:suckling behavior; IEA:Ensembl. DR GO; GO:0044342; P:type B pancreatic cell proliferation; IEA:Ensembl. DR CDD; cd21081; DHD_Dac; 1. DR Gene3D; 3.10.260.20; Ski; 1. DR InterPro; IPR009061; DNA-bd_dom_put_sf. DR InterPro; IPR003380; SKI/SNO/DAC. DR InterPro; IPR037000; Ski_DNA-bd_sf. DR PANTHER; PTHR12577; DACHSHUND; 1. DR PANTHER; PTHR12577:SF14; DACHSHUND HOMOLOG 1; 1. DR Pfam; PF02437; Ski_Sno; 1. DR SUPFAM; SSF46955; Putative DNA-binding domain; 1. PE 3: Inferred from homology; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Reference proteome {ECO:0000313|Proteomes:UP000002281}. FT DOMAIN 142..235 FT /note="SKI/SNO/DAC" FT /evidence="ECO:0000259|Pfam:PF02437" FT REGION 1..62 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 86..125 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 234..267 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 312..364 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 428..540 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COILED 587..670 FT /evidence="ECO:0000256|SAM:Coils" FT COMPBIAS 18..44 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 93..121 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 234..258 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 312..350 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 462..499 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 513..535 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 714 AA; 76581 MW; 735D3EEE3BC72090 CRC64; MAVPAALIPP TQLVPPQPPI STSASSSGTT TSTSSATSSP APSIGPPASS GPTLFRPEPI ASAAAASTVQ SELFLSFPKS WKQDAVGPNS PFGRSLHHTQ SRSPTSGQSS SSSSRSPTSA RIRPGKETGV FTGLWXXXXX XXXMVDLRGA KVASFTVEGC ELICLPQAFD LFLKHLVGGL HTVYTKLKRL EITPVVCNVE QVRILRGLGA IQPGVNRCKL ISRKDFETLY NDCTNASSRP GRPPKRTQSV TSPENSHIMP HSVPGLMSPG IIPPTGLTAA AAAAAAATNA AIAEAMKVKK IKLEAMSNYH ASNNQHGADS ENGDMNSSVG NSDGSWDKET LSSFLPQGAQ ASATHPRRPG ARSLAVSHPF HHLQHGHLLP NGLELPFMMM PHPLIPVSLP PASVTMAMSQ MNHLSTIANM AAAAQVQSPP SRVETSVIKE RVPDSPSPAP SLEEGRRPGS HPSSHRSSSV SSSPARTESS SDRIPVHQNG LSMNQMLMGL SPNVLPGPKE GDLAGHDLGH ESKRMHIEKD ETPLSTPTAR DSLDKLSLAG HGQPLPPGFP SPFLFPDGLS SIETLLTNIQ GLLKVAIDNA RAQEKQVQLE KTELKMDFLR ERELRETLEK QLAMEQKNRA IVQKRLKKEK KAKRKLQEAL EFETKRREQA EQTLKQAAST DSLRVLNDSL TPEIEADRSG GRTDAERTIQ GRNLQKAINL DLAI //