ID A0A3Q2I8F7_HORSE Unreviewed; 712 AA. AC A0A3Q2I8F7; DT 10-APR-2019, integrated into UniProtKB/TrEMBL. DT 10-APR-2019, sequence version 1. DT 07-APR-2021, entry version 10. DE SubName: Full=Dachshund family transcription factor 1 {ECO:0000313|Ensembl:ENSECAP00000044280}; GN Name=DACH1 {ECO:0000313|Ensembl:ENSECAP00000044280, GN ECO:0000313|VGNC:VGNC:16996}; OS Equus caballus (Horse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus. OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000044280, ECO:0000313|Proteomes:UP000002281}; RN [1] {ECO:0000313|Ensembl:ENSECAP00000044280, ECO:0000313|Proteomes:UP000002281} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000044280, RC ECO:0000313|Proteomes:UP000002281}; RX PubMed=19892987; DOI=10.1126/science.1178158; RG Broad Institute Genome Sequencing Platform; RG Broad Institute Whole Genome Assembly Team; RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F., RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O., RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T., RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T., RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S., RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G., RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R., RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A., RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J., RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.; RT "Genome sequence, comparative analysis, and population genetics of the RT domestic horse."; RL Science 326:865-867(2009). RN [2] {ECO:0000313|Ensembl:ENSECAP00000044280} RP IDENTIFICATION. RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000044280}; RG Ensembl; RL Submitted (JAN-2019) to UniProtKB. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR Ensembl; ENSECAT00000063439; ENSECAP00000044280; ENSECAG00000017699. DR VGNC; VGNC:16996; DACH1. DR GeneTree; ENSGT00390000001134; -. DR Proteomes; UP000002281; Chromosome 17. DR ExpressionAtlas; A0A3Q2I8F7; baseline. DR GO; GO:0005737; C:cytoplasm; IEA:Ensembl. DR GO; GO:0005634; C:nucleus; IBA:GO_Central. DR GO; GO:0005667; C:transcription regulator complex; IBA:GO_Central. DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central. DR GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; IEA:Ensembl. DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central. DR GO; GO:0008283; P:cell population proliferation; IEA:Ensembl. DR GO; GO:0046545; P:development of primary female sexual characteristics; IEA:Ensembl. DR GO; GO:0030336; P:negative regulation of cell migration; IEA:Ensembl. DR GO; GO:0060244; P:negative regulation of cell proliferation involved in contact inhibition; IEA:Ensembl. DR GO; GO:2000279; P:negative regulation of DNA biosynthetic process; IEA:Ensembl. DR GO; GO:0048147; P:negative regulation of fibroblast proliferation; IEA:Ensembl. DR GO; GO:0010944; P:negative regulation of transcription by competitive promoter binding; IEA:Ensembl. DR GO; GO:0033262; P:regulation of nuclear cell cycle DNA replication; IEA:Ensembl. DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central. DR GO; GO:0007585; P:respiratory gaseous exchange by respiratory system; IEA:Ensembl. DR GO; GO:0001967; P:suckling behavior; IEA:Ensembl. DR Gene3D; 3.10.260.20; -; 1. DR InterPro; IPR009061; DNA-bd_dom_put_sf. DR InterPro; IPR003380; SKI/SNO/DAC. DR InterPro; IPR037000; Ski_DNA-bd_sf. DR Pfam; PF02437; Ski_Sno; 1. DR SUPFAM; SSF46955; SSF46955; 1. PE 4: Predicted; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Reference proteome {ECO:0000313|Proteomes:UP000002281}. FT DOMAIN 142..235 FT /note="Ski_Sno" FT /evidence="ECO:0000259|Pfam:PF02437" FT REGION 1..62 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 86..125 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 234..267 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 312..364 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 428..540 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COILED 587..612 FT /evidence="ECO:0000256|SAM:Coils" FT COILED 615..670 FT /evidence="ECO:0000256|SAM:Coils" FT COMPBIAS 18..44 FT /note="Polar" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 93..121 FT /note="Polar" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 234..258 FT /note="Polar" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 312..350 FT /note="Polar" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 462..499 FT /note="Polar" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 513..535 FT /note="Polyampholyte" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 712 AA; 76504 MW; 4A564709258C7CAF CRC64; MAVPAALIPP TQLVPPQPPI STSASSSGTT TSTSSATSSP APSIGPPASS GPTLFRPEPI ASAAAASTVQ SELFLSFPKS WKQDAVGPNS PFGRSLHHTQ SRSPTSGQSS SSSSRSPTSA RIRPGKETGV FTGLWXXXXX XXXMVDLRGA KVASFTVEGC ELICLPQAFD LFLKHLVGGL HTVYTKLKRL EITPVVCNVE QVRILRGLGA IQPGVNRCKL ISRKDFETLY NDCTNASSRP GRPPKRTQSV TSPENSHIMP HSVPGLMSPG IIPPTGLTAA AAAAAAATNA AIAEAMKVKK IKLEAMSNYH ASNNQHGADS ENGDMNSSVG NSDGSWDKET LSSFLPQGAQ ASATHPRRPG ARSLAVSHPF HHLQHGHLLP NGLELPFMMM PHPLIPVSLP PASVTMAMSQ MNHLSTIANM AAAAQVQSPP SRVETSVIKE RVPDSPSPAP SLEEGRRPGS HPSSHRSSSV SSSPARTESS SDRIPVHQNG LSMNQMLMGL SPNVLPGPKE GDLAGHDLGH ESKRMHIEKD ETPLSTPTAR DSLDKLSLAG HGQPLPPGFP SPFLFPDGLS SIETLLTNIQ GLLKVAIDNA RAQEKQVQLE KTELKMDFLR ERELRETLEK QLAMEQKNRA IVQKRLKKEK KAKRKLQEAL EFETKRREQA EQTLKQAAST DSLRVLNDSL TPEIEADRSG GRTDAERTIQ VFNKTTTIYD FN //