ID A0A3Q2I6A8_HORSE Unreviewed; 462 AA. AC A0A3Q2I6A8; DT 10-APR-2019, integrated into UniProtKB/TrEMBL. DT 13-SEP-2023, sequence version 2. DT 08-NOV-2023, entry version 20. DE SubName: Full=DiGeorge syndrome critical region gene 2 {ECO:0000313|Ensembl:ENSECAP00000043440.2}; GN Name=DGCR2 {ECO:0000313|Ensembl:ENSECAP00000043440.2}; OS Equus caballus (Horse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus. OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000043440.2, ECO:0000313|Proteomes:UP000002281}; RN [1] {ECO:0000313|Ensembl:ENSECAP00000043440.2, ECO:0000313|Proteomes:UP000002281} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000043440.2, RC ECO:0000313|Proteomes:UP000002281}; RX PubMed=19892987; DOI=10.1126/science.1178158; RG Broad Institute Genome Sequencing Platform; RG Broad Institute Whole Genome Assembly Team; RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F., RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O., RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T., RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T., RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S., RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G., RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R., RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A., RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J., RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.; RT "Genome sequence, comparative analysis, and population genetics of the RT domestic horse."; RL Science 326:865-867(2009). RN [2] {ECO:0000313|Ensembl:ENSECAP00000043440.2} RP IDENTIFICATION. RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000043440.2}; RG Ensembl; RL Submitted (JUL-2023) to UniProtKB. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR AlphaFoldDB; A0A3Q2I6A8; -. DR STRING; 9796.ENSECAP00000043440; -. DR PaxDb; 9796-ENSECAP00000043440; -. DR Ensembl; ENSECAT00000043558.2; ENSECAP00000043440.2; ENSECAG00000014063.4. DR GeneTree; ENSGT00390000017655; -. DR InParanoid; A0A3Q2I6A8; -. DR OMA; RYRAQQM; -. DR Proteomes; UP000002281; Chromosome 8. DR Bgee; ENSECAG00000014063; Expressed in oviduct epithelium and 23 other tissues. DR GO; GO:0016020; C:membrane; IBA:GO_Central. DR GO; GO:0050890; P:cognition; IEA:Ensembl. DR CDD; cd03599; CLECT_DGCR2_like; 1. DR Gene3D; 3.10.100.10; Mannose-Binding Protein A, subunit A; 1. DR InterPro; IPR001304; C-type_lectin-like. DR InterPro; IPR016186; C-type_lectin-like/link_sf. DR InterPro; IPR016187; CTDL_fold. DR InterPro; IPR034010; DGCR2-like_CTLD. DR InterPro; IPR042378; IDD. DR InterPro; IPR001007; VWF_dom. DR PANTHER; PTHR15256; INTEGRAL MEMBRANE PROTEIN DGCR2/IDD; 1. DR PANTHER; PTHR15256:SF6; INTEGRAL MEMBRANE PROTEIN DGCR2/IDD; 1. DR Pfam; PF00059; Lectin_C; 1. DR SMART; SM00034; CLECT; 1. DR SMART; SM00214; VWC; 1. DR SUPFAM; SSF56436; C-type lectin-like; 1. DR PROSITE; PS50041; C_TYPE_LECTIN_2; 1. DR PROSITE; PS01208; VWFC_1; 1. PE 4: Predicted; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000002281}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 260..280 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT DOMAIN 36..178 FT /note="C-type lectin" FT /evidence="ECO:0000259|PROSITE:PS50041" FT REGION 325..462 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 344..366 FT /note="Pro residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 429..462 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 462 AA; 51179 MW; F94C1DE993C3BB86 CRC64; MGGIHEYTWP LFPSVSERSL SISQRKCPTG WHHYEGTASC YRVYLSGENY WDAAQTCQRV NGSLATFSTD QELRFVLAQE WDQPERSFAW QDQHKLWVGY QYVVTGRNRS LEGHWEVAFK GSSEVFLPPD PIFASAMSES DNVFCAQLQC FHFPTLRHHD LHSWHAENCY EKSSFLCKRS QTCVDIKDNV VDEGFYFTPK GDDPCLSCTC HGGEPEMCVA ALCERPQGCQ QYRKDPKECC KFMCLDPDGN SLFDSMASGM RLIVSCISSF LILSLLLFMV HRLRQRRRER IESLIGANLH HFNLGRRIPG FDYGPDGFGT GLTPLHLSDD GEGGTFHFHD PPPPYTAYKY PDIDQPDDPP PPYEASINPD SVFYDPADDD AFEPAEAGPP TPGDGGGEGA SSRCLEQPLP ATGAPLADLE DSADSSSALL VPPDPTQSGS TSATEALPGG GHHSRSSLNT VV //