ID A0A3Q2I6A8_HORSE Unreviewed; 550 AA. AC A0A3Q2I6A8; DT 10-APR-2019, integrated into UniProtKB/TrEMBL. DT 10-APR-2019, sequence version 1. DT 03-AUG-2022, entry version 13. DE SubName: Full=DiGeorge syndrome critical region gene 2 {ECO:0000313|Ensembl:ENSECAP00000043440}; GN Name=DGCR2 {ECO:0000313|Ensembl:ENSECAP00000043440}; OS Equus caballus (Horse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus. OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000043440, ECO:0000313|Proteomes:UP000002281}; RN [1] {ECO:0000313|Ensembl:ENSECAP00000043440, ECO:0000313|Proteomes:UP000002281} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000043440, RC ECO:0000313|Proteomes:UP000002281}; RX PubMed=19892987; DOI=10.1126/science.1178158; RG Broad Institute Genome Sequencing Platform; RG Broad Institute Whole Genome Assembly Team; RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F., RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O., RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T., RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T., RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S., RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G., RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R., RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A., RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J., RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.; RT "Genome sequence, comparative analysis, and population genetics of the RT domestic horse."; RL Science 326:865-867(2009). RN [2] {ECO:0000313|Ensembl:ENSECAP00000043440} RP IDENTIFICATION. RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000043440}; RG Ensembl; RL Submitted (JAN-2019) to UniProtKB. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR STRING; 9796.ENSECAP00000043440; -. DR Ensembl; ENSECAT00000043558; ENSECAP00000043440; ENSECAG00000014063. DR GeneTree; ENSGT00390000017655; -. DR Proteomes; UP000002281; Chromosome 8. DR Bgee; ENSECAG00000014063; Expressed in oviduct epithelium and 23 other tissues. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0016020; C:membrane; IBA:GO_Central. DR GO; GO:0050890; P:cognition; IEA:Ensembl. DR Gene3D; 3.10.100.10; -; 1. DR InterPro; IPR001304; C-type_lectin-like. DR InterPro; IPR016186; C-type_lectin-like/link_sf. DR InterPro; IPR016187; CTDL_fold. DR InterPro; IPR042378; IDD. DR InterPro; IPR001007; VWF_dom. DR PANTHER; PTHR15256; PTHR15256; 1. DR Pfam; PF00059; Lectin_C; 1. DR SMART; SM00034; CLECT; 1. DR SMART; SM00214; VWC; 1. DR SUPFAM; SSF56436; SSF56436; 1. DR PROSITE; PS01208; VWFC_1; 1. PE 4: Predicted; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000002281}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 348..368 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT DOMAIN 293..332 FT /note="VWFC" FT /evidence="ECO:0000259|PROSITE:PS01208" FT REGION 413..550 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 432..454 FT /note="Pro residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 517..550 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 550 AA; 59863 MW; 7963FF17C759F9ED CRC64; MVQPSGGRAG LLGFKENLTE RHTCGPAPAP PGPSGLTVLC FDITLAPESC PRPVPRRIIS RAHSPLLSLL SEVTGESRPY HGKEAVDPRQ GRARGGEPTH LHAVNVAQPV RFSSKLQTWK CPTGWHHYEG TASCYRVYLS GENYWDAAQT CQRVNGSLAT FSTDQELRFV LAQEWDQPER RGPWSPCGLC VTGVLTSCNG RAPFVFPTGS SEVFLPPDPI FASAMSESDN VFCAQLQCFH FPTLRHHDLH SWHAENCYEK SSFLCKRSQT CVDIKDNVVD EGFYFTPKGD DPCLSCTCHG GEPEMCVAAL CERPQGCQQY RKDPKECCKF MCLDPDGNSL FDSMASGMRL IVSCISSFLI LSLLLFMVHR LRQRRRERIE SLIGANLHHF NLGRRIPGFD YGPDGFGTGL TPLHLSDDGE GGTFHFHDPP PPYTAYKYPD IDQPDDPPPP YEASINPDSV FYDPADDDAF EPAEAGPPTP GDGGGEGASS RCLEQPLPAT GAPLADLEDS ADSSSALLVP PDPTQSGSTS ATEALPGGGH HSRSSLNTVV //