ID   A0A3Q2I5Q7_HORSE        Unreviewed;      1192 AA.
AC   A0A3Q2I5Q7;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   03-JUL-2019, entry version 4.
DE   RecName: Full=Receptor protein-tyrosine kinase {ECO:0000256|SAAS:SAAS00593197};
DE            EC=2.7.10.1 {ECO:0000256|SAAS:SAAS00593197};
GN   Name=EGFR {ECO:0000313|Ensembl:ENSECAP00000043331,
GN   ECO:0000313|VGNC:VGNC:17460};
OS   Equus caballus (Horse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX   NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000043331, ECO:0000313|Proteomes:UP000002281};
RN   [1] {ECO:0000313|Ensembl:ENSECAP00000043331, ECO:0000313|Proteomes:UP000002281}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000043331,
RC   ECO:0000313|Proteomes:UP000002281};
RX   PubMed=19892987; DOI=10.1126/science.1178158;
RG   Broad Institute Genome Sequencing Platform;
RG   Broad Institute Whole Genome Assembly Team;
RA   Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA   Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H.,
RA   Distl O., Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N.,
RA   Penedo M.C.T., Raison J.M., Sharpe T., Vogel J., Andersson L.,
RA   Antczak D.F., Biagi T., Binns M.M., Chowdhary B.P., Coleman S.J.,
RA   Della Valle G., Fryc S., Guerin G., Hasegawa T., Hill E.W., Jurka J.,
RA   Kiialainen A., Lindgren G., Liu J., Magnani E., Mickelson J.R.,
RA   Murray J., Nergadze S.G., Onofrio R., Pedroni S., Piras M.F.,
RA   Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A., Searle S., Skow L.,
RA   Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J., Vaudin M.,
RA   White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT   "Genome sequence, comparative analysis, and population genetics of the
RT   domestic horse.";
RL   Science 326:865-867(2009).
RN   [2] {ECO:0000313|Ensembl:ENSECAP00000043331}
RP   IDENTIFICATION.
RC   STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000043331};
RG   Ensembl;
RL   Submitted (JAN-2019) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-
CC         tyrosyl-[protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136,
CC         Rhea:RHEA-COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216;
CC         EC=2.7.10.1; Evidence={ECO:0000256|SAAS:SAAS01123262};
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily. Tyr protein
CC       kinase family. {ECO:0000256|SAAS:SAAS00941529}.
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DR   Ensembl; ENSECAT00000042132; ENSECAP00000043331; ENSECAG00000009952.
DR   VGNC; VGNC:17460; EGFR.
DR   GeneTree; ENSGT00940000155450; -.
DR   Proteomes; UP000002281; Chromosome 4.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004714; F:transmembrane receptor protein tyrosine kinase activity; IEA:UniProtKB-EC.
DR   GO; GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway; IEA:InterPro.
DR   CDD; cd00064; FU; 3.
DR   Gene3D; 3.80.20.20; -; 2.
DR   InterPro; IPR006211; Furin-like_Cys-rich_dom.
DR   InterPro; IPR006212; Furin_repeat.
DR   InterPro; IPR032778; GF_recep_IV.
DR   InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   InterPro; IPR017441; Protein_kinase_ATP_BS.
DR   InterPro; IPR000494; Rcpt_L-dom.
DR   InterPro; IPR036941; Rcpt_L-dom_sf.
DR   InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR   InterPro; IPR008266; Tyr_kinase_AS.
DR   InterPro; IPR020635; Tyr_kinase_cat_dom.
DR   InterPro; IPR016245; Tyr_kinase_EGF/ERB/XmrK_rcpt.
DR   Pfam; PF00757; Furin-like; 1.
DR   Pfam; PF14843; GF_recep_IV; 1.
DR   Pfam; PF07714; Pkinase_Tyr; 1.
DR   Pfam; PF01030; Recep_L_domain; 2.
DR   PIRSF; PIRSF000619; TyrPK_EGF-R; 2.
DR   PRINTS; PR00109; TYRKINASE.
DR   SMART; SM00261; FU; 4.
DR   SMART; SM00219; TyrKc; 1.
DR   SUPFAM; SSF56112; SSF56112; 1.
DR   SUPFAM; SSF57184; SSF57184; 2.
DR   PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|PIRSR:PIRSR000619-2,
KW   ECO:0000256|SAAS:SAAS00245980};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002281};
KW   Kinase {ECO:0000256|SAAS:SAAS00594439};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Nucleotide-binding {ECO:0000256|SAAS:SAAS00244405};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transferase {ECO:0000256|SAAS:SAAS00595469};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Tyrosine-protein kinase {ECO:0000256|SAAS:SAAS00594505}.
FT   SIGNAL        1     24       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        25   1192       Receptor protein-tyrosine kinase.
FT                                {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5018752115.
FT   TRANSMEM    646    668       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      712    979       Protein kinase. {ECO:0000259|PROSITE:
FT                                PS50011}.
FT   NP_BIND     718    726       ATP. {ECO:0000256|PIRSR:PIRSR000619-2}.
FT   REGION     1078   1122       Disordered. {ECO:0000256|MobiDB-lite:
FT                                A0A3Q2I5Q7}.
FT   COMPBIAS   1081   1095       Polar. {ECO:0000256|MobiDB-lite:
FT                                A0A3Q2I5Q7}.
FT   ACT_SITE    837    837       Proton acceptor. {ECO:0000256|PIRSR:
FT                                PIRSR000619-1}.
FT   BINDING     745    745       ATP. {ECO:0000256|PIRSR:PIRSR000619-2}.
SQ   SEQUENCE   1192 AA;  132850 MW;  A131BB33E5064309 CRC64;
     MRHSGTVGAA LLVLLAAYFQ ASPALEEKKV CQGTSNRLTQ LGTFEDHFLS LQRMFNNCEV
     VLGNLEITYM QKNYDLSFLK TIQEVAGYVL IALNTVEKIP LENLQIIRGN VLYENTHALS
     VLSNYGANKV GLRELPMRNL QEILQGAVRF SNNPILCNME TIQWRDIVNS DFLSNMSVDF
     QNQLGSCQKC DPACPNGSCW GVGKENCQKL TKTICAQQCS GRCRGRSPSD CCHNQCAAGC
     TGPRESDCLV CRKFRDEATC KDTCPPLMLY NPTTYQMDVN PDGKYSFGAT CVKKCPRNYV
     VTDHGSCVRA CSSDSYEVEE DGVRKCKKCE GPCRKVCNGI GIGEFKDTLS INATNIKHFK
     NCTSISGDLH ILPVAFRGDS FTRTPPLDPK ELDILQTVKE ITGFLLIQAW PENRTDLHAF
     ENLEIIRGRT KQHGQFSLAV VGLDITSLGL RSLKEISDGD VIISGNRNLC YANTIKWKKL
     FGTSSQKTKI INNRSEKDCK TVGHVCNLLC SSEGCWGPEP RDCVSCQNVS RGKECVEKCN
     ILEGEPREFV ENSECIQCHP ECLPQAMNIT CTGRGPDNCI KCAHYIDGPH CVKTCPSGIM
     GENNTLVWKF ADANHVCHLC HPNCTYGCAG PGLEGCARNG PKIPSIATGI VGGLLLVVVV
     ALGIGLFLRR RHIVRKRTLR RLLQERELVE PLTPSGEAPN QALLRILKET EFKKIKVLGS
     GAFGTVYKGL WIPEGEKVKI PVAIKELREA TSPKANKEIL DEAYVMASVD NPHVCRLLGI
     CLTSTVQLIT QLMPFGCLLD YVREHKDNIG SQYLLNWCVQ IAKGMNYLED RRLVHRDLAA
     RNVLVKTPQH VKITDFGLAK LLGAEEKEYH AEGGKVPIKW MALESILHRI YTHQSDVWSY
     GVTVWELMTF GSKPYDGIPA SEISTILEKG ERLPQPPICT IDVYMIMVKC WMIDADSRPK
     FRELIIEFSK MARDPQRYLV IQGDERMHLP SPTDSNFYRT LMDEEDMEDV VDADEYLIPQ
     QGFFHSPSTS RTPLISSLSC PLKEDSFLQR YSSDPTGTVT EDNIDDTFLP APEYVNQSVP
     KRPAGSVQNP VYHNQPLNPA PGRDPHYQNP HSNAMDNPEY LNTTHPDCVN SVLDGTALWA
     QKGNHQISLD NPDYQQDFFP KEAKSNGIFK GPAAENAEYL RVAPPSSEFI GA
//