ID A0A3Q2I5Q7_HORSE Unreviewed; 1192 AA. AC A0A3Q2I5Q7; DT 10-APR-2019, integrated into UniProtKB/TrEMBL. DT 10-APR-2019, sequence version 1. DT 03-MAY-2023, entry version 21. DE RecName: Full=Receptor protein-tyrosine kinase {ECO:0000256|ARBA:ARBA00011902, ECO:0000256|PIRNR:PIRNR000619}; DE EC=2.7.10.1 {ECO:0000256|ARBA:ARBA00011902, ECO:0000256|PIRNR:PIRNR000619}; GN Name=EGFR {ECO:0000313|Ensembl:ENSECAP00000043331.1, GN ECO:0000313|VGNC:VGNC:17460}; OS Equus caballus (Horse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus. OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000043331.1, ECO:0000313|Proteomes:UP000002281}; RN [1] {ECO:0000313|Ensembl:ENSECAP00000043331.1, ECO:0000313|Proteomes:UP000002281} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000043331.1, RC ECO:0000313|Proteomes:UP000002281}; RX PubMed=19892987; DOI=10.1126/science.1178158; RG Broad Institute Genome Sequencing Platform; RG Broad Institute Whole Genome Assembly Team; RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F., RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O., RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T., RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T., RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S., RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G., RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R., RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A., RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J., RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.; RT "Genome sequence, comparative analysis, and population genetics of the RT domestic horse."; RL Science 326:865-867(2009). RN [2] {ECO:0000313|Ensembl:ENSECAP00000043331.1} RP IDENTIFICATION. RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000043331.1}; RG Ensembl; RL Submitted (JAN-2023) to UniProtKB. CC -!- CATALYTIC ACTIVITY: CC Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- CC [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA- CC COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, CC ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.1; CC Evidence={ECO:0000256|ARBA:ARBA00001171}; CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single- CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}. CC -!- SIMILARITY: Belongs to the protein kinase superfamily. Tyr protein CC kinase family. EGF receptor subfamily. {ECO:0000256|PIRNR:PIRNR000619}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR AlphaFoldDB; A0A3Q2I5Q7; -. DR Ensembl; ENSECAT00000042132.1; ENSECAP00000043331.1; ENSECAG00000009952.3. DR VGNC; VGNC:17460; EGFR. DR GeneTree; ENSGT00940000155450; -. DR Proteomes; UP000002281; Chromosome 4. DR Bgee; ENSECAG00000009952; Expressed in trophoblast and 20 other tissues. DR ExpressionAtlas; A0A3Q2I5Q7; baseline. DR GO; GO:0016323; C:basolateral plasma membrane; IEA:Ensembl. DR GO; GO:0030054; C:cell junction; IEA:Ensembl. DR GO; GO:0009986; C:cell surface; IEA:Ensembl. DR GO; GO:0031901; C:early endosome membrane; IEA:Ensembl. DR GO; GO:0030139; C:endocytic vesicle; IEA:Ensembl. DR GO; GO:0045121; C:membrane raft; IEA:Ensembl. DR GO; GO:0097489; C:multivesicular body, internal vesicle lumen; IEA:Ensembl. DR GO; GO:0005634; C:nucleus; IEA:Ensembl. DR GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:Ensembl. DR GO; GO:0043235; C:receptor complex; IEA:Ensembl. DR GO; GO:0032587; C:ruffle membrane; IEA:Ensembl. DR GO; GO:0051015; F:actin filament binding; IEA:Ensembl. DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule. DR GO; GO:0003682; F:chromatin binding; IEA:Ensembl. DR GO; GO:0048408; F:epidermal growth factor binding; IEA:Ensembl. DR GO; GO:0005006; F:epidermal growth factor receptor activity; IEA:Ensembl. DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl. DR GO; GO:0019900; F:kinase binding; IEA:Ensembl. DR GO; GO:0030235; F:nitric-oxide synthase regulator activity; IEA:Ensembl. DR GO; GO:0019903; F:protein phosphatase binding; IEA:Ensembl. DR GO; GO:0030297; F:transmembrane receptor protein tyrosine kinase activator activity; IEA:Ensembl. DR GO; GO:0031625; F:ubiquitin protein ligase binding; IEA:Ensembl. DR GO; GO:0000902; P:cell morphogenesis; IEA:Ensembl. DR GO; GO:0098609; P:cell-cell adhesion; IEA:Ensembl. DR GO; GO:0071230; P:cellular response to amino acid stimulus; IEA:Ensembl. DR GO; GO:0071276; P:cellular response to cadmium ion; IEA:Ensembl. DR GO; GO:0071392; P:cellular response to estradiol stimulus; IEA:Ensembl. DR GO; GO:0071363; P:cellular response to growth factor stimulus; IEA:Ensembl. DR GO; GO:0034614; P:cellular response to reactive oxygen species; IEA:Ensembl. DR GO; GO:0021795; P:cerebral cortex cell migration; IEA:Ensembl. DR GO; GO:0048546; P:digestive tract morphogenesis; IEA:Ensembl. DR GO; GO:0001892; P:embryonic placenta development; IEA:Ensembl. DR GO; GO:0050673; P:epithelial cell proliferation; IEA:Ensembl. DR GO; GO:0038134; P:ERBB2-EGFR signaling pathway; IEA:Ensembl. DR GO; GO:0061029; P:eyelid development in camera-type eye; IEA:Ensembl. DR GO; GO:0001942; P:hair follicle development; IEA:Ensembl. DR GO; GO:0060571; P:morphogenesis of an epithelial fold; IEA:Ensembl. DR GO; GO:0043066; P:negative regulation of apoptotic process; IEA:Ensembl. DR GO; GO:1905208; P:negative regulation of cardiocyte differentiation; IEA:Ensembl. DR GO; GO:0042177; P:negative regulation of protein catabolic process; IEA:Ensembl. DR GO; GO:0038083; P:peptidyl-tyrosine autophosphorylation; IEA:Ensembl. DR GO; GO:0090263; P:positive regulation of canonical Wnt signaling pathway; IEA:Ensembl. DR GO; GO:0030307; P:positive regulation of cell growth; IEA:Ensembl. DR GO; GO:0030335; P:positive regulation of cell migration; IEA:Ensembl. DR GO; GO:0045737; P:positive regulation of cyclin-dependent protein serine/threonine kinase activity; IEA:Ensembl. DR GO; GO:0045739; P:positive regulation of DNA repair; IEA:Ensembl. DR GO; GO:0045740; P:positive regulation of DNA replication; IEA:Ensembl. DR GO; GO:0050679; P:positive regulation of epithelial cell proliferation; IEA:Ensembl. DR GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IEA:Ensembl. DR GO; GO:0048146; P:positive regulation of fibroblast proliferation; IEA:Ensembl. DR GO; GO:1900087; P:positive regulation of G1/S transition of mitotic cell cycle; IEA:Ensembl. DR GO; GO:0043406; P:positive regulation of MAP kinase activity; IEA:Ensembl. DR GO; GO:1902895; P:positive regulation of miRNA transcription; IEA:Ensembl. DR GO; GO:1901224; P:positive regulation of NIK/NF-kappaB signaling; IEA:Ensembl. DR GO; GO:0010750; P:positive regulation of nitric oxide mediated signal transduction; IEA:Ensembl. DR GO; GO:0033138; P:positive regulation of peptidyl-serine phosphorylation; IEA:Ensembl. DR GO; GO:0051897; P:positive regulation of protein kinase B signaling; IEA:Ensembl. DR GO; GO:1900020; P:positive regulation of protein kinase C activity; IEA:Ensembl. DR GO; GO:1903078; P:positive regulation of protein localization to plasma membrane; IEA:Ensembl. DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:Ensembl. DR GO; GO:0046328; P:regulation of JNK cascade; IEA:Ensembl. DR GO; GO:0050999; P:regulation of nitric-oxide synthase activity; IEA:Ensembl. DR GO; GO:0050730; P:regulation of peptidyl-tyrosine phosphorylation; IEA:Ensembl. DR GO; GO:0014066; P:regulation of phosphatidylinositol 3-kinase signaling; IEA:Ensembl. DR GO; GO:0070141; P:response to UV-A; IEA:Ensembl. DR GO; GO:0007435; P:salivary gland morphogenesis; IEA:Ensembl. DR CDD; cd00064; FU; 3. DR CDD; cd05108; PTKc_EGFR; 1. DR Gene3D; 6.10.250.2930; -; 1. DR Gene3D; 3.80.20.20; Receptor L-domain; 2. DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1. DR InterPro; IPR044912; Egfr_JX_dom. DR InterPro; IPR006211; Furin-like_Cys-rich_dom. DR InterPro; IPR006212; Furin_repeat. DR InterPro; IPR032778; GF_recep_IV. DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf. DR InterPro; IPR011009; Kinase-like_dom_sf. DR InterPro; IPR000719; Prot_kinase_dom. DR InterPro; IPR017441; Protein_kinase_ATP_BS. DR InterPro; IPR000494; Rcpt_L-dom. DR InterPro; IPR036941; Rcpt_L-dom_sf. DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom. DR InterPro; IPR008266; Tyr_kinase_AS. DR InterPro; IPR020635; Tyr_kinase_cat_dom. DR InterPro; IPR016245; Tyr_kinase_EGF/ERB/XmrK_rcpt. DR PANTHER; PTHR24416:SF91; EPIDERMAL GROWTH FACTOR RECEPTOR; 1. DR PANTHER; PTHR24416; TYROSINE-PROTEIN KINASE RECEPTOR; 1. DR Pfam; PF00757; Furin-like; 1. DR Pfam; PF14843; GF_recep_IV; 1. DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1. DR Pfam; PF01030; Recep_L_domain; 2. DR PIRSF; PIRSF000619; TyrPK_EGF-R; 2. DR PRINTS; PR00109; TYRKINASE. DR SMART; SM00261; FU; 4. DR SMART; SM00219; TyrKc; 1. DR SUPFAM; SSF57184; Growth factor receptor domain; 2. DR SUPFAM; SSF52058; L domain-like; 2. DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1. DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1. DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1. DR PROSITE; PS00109; PROTEIN_KINASE_TYR; 1. PE 3: Inferred from homology; KW ATP-binding {ECO:0000256|PIRNR:PIRNR000619, ECO:0000256|PIRSR:PIRSR000619- KW 2}; Kinase {ECO:0000256|PIRNR:PIRNR000619}; KW Membrane {ECO:0000256|PIRNR:PIRNR000619, ECO:0000256|SAM:Phobius}; KW Nucleotide-binding {ECO:0000256|PIRNR:PIRNR000619, ECO:0000256|PROSITE- KW ProRule:PRU10141}; Receptor {ECO:0000256|PIRNR:PIRNR000619}; KW Reference proteome {ECO:0000313|Proteomes:UP000002281}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transferase {ECO:0000256|PIRNR:PIRNR000619}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, KW ECO:0000256|SAM:Phobius}; KW Tyrosine-protein kinase {ECO:0000256|ARBA:ARBA00023137, KW ECO:0000256|PIRNR:PIRNR000619}. FT SIGNAL 1..24 FT /evidence="ECO:0000256|SAM:SignalP" FT CHAIN 25..1192 FT /note="Receptor protein-tyrosine kinase" FT /evidence="ECO:0000256|SAM:SignalP" FT /id="PRO_5018752115" FT TRANSMEM 646..668 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT DOMAIN 712..979 FT /note="Protein kinase" FT /evidence="ECO:0000259|PROSITE:PS50011" FT REGION 1078..1122 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 1081..1095 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT ACT_SITE 837 FT /note="Proton acceptor" FT /evidence="ECO:0000256|PIRSR:PIRSR000619-1" FT BINDING 718..726 FT /ligand="ATP" FT /ligand_id="ChEBI:CHEBI:30616" FT /evidence="ECO:0000256|PIRSR:PIRSR000619-2" FT BINDING 745 FT /ligand="ATP" FT /ligand_id="ChEBI:CHEBI:30616" FT /evidence="ECO:0000256|PIRSR:PIRSR000619-2, FT ECO:0000256|PROSITE-ProRule:PRU10141" SQ SEQUENCE 1192 AA; 132850 MW; A131BB33E5064309 CRC64; MRHSGTVGAA LLVLLAAYFQ ASPALEEKKV CQGTSNRLTQ LGTFEDHFLS LQRMFNNCEV VLGNLEITYM QKNYDLSFLK TIQEVAGYVL IALNTVEKIP LENLQIIRGN VLYENTHALS VLSNYGANKV GLRELPMRNL QEILQGAVRF SNNPILCNME TIQWRDIVNS DFLSNMSVDF QNQLGSCQKC DPACPNGSCW GVGKENCQKL TKTICAQQCS GRCRGRSPSD CCHNQCAAGC TGPRESDCLV CRKFRDEATC KDTCPPLMLY NPTTYQMDVN PDGKYSFGAT CVKKCPRNYV VTDHGSCVRA CSSDSYEVEE DGVRKCKKCE GPCRKVCNGI GIGEFKDTLS INATNIKHFK NCTSISGDLH ILPVAFRGDS FTRTPPLDPK ELDILQTVKE ITGFLLIQAW PENRTDLHAF ENLEIIRGRT KQHGQFSLAV VGLDITSLGL RSLKEISDGD VIISGNRNLC YANTIKWKKL FGTSSQKTKI INNRSEKDCK TVGHVCNLLC SSEGCWGPEP RDCVSCQNVS RGKECVEKCN ILEGEPREFV ENSECIQCHP ECLPQAMNIT CTGRGPDNCI KCAHYIDGPH CVKTCPSGIM GENNTLVWKF ADANHVCHLC HPNCTYGCAG PGLEGCARNG PKIPSIATGI VGGLLLVVVV ALGIGLFLRR RHIVRKRTLR RLLQERELVE PLTPSGEAPN QALLRILKET EFKKIKVLGS GAFGTVYKGL WIPEGEKVKI PVAIKELREA TSPKANKEIL DEAYVMASVD NPHVCRLLGI CLTSTVQLIT QLMPFGCLLD YVREHKDNIG SQYLLNWCVQ IAKGMNYLED RRLVHRDLAA RNVLVKTPQH VKITDFGLAK LLGAEEKEYH AEGGKVPIKW MALESILHRI YTHQSDVWSY GVTVWELMTF GSKPYDGIPA SEISTILEKG ERLPQPPICT IDVYMIMVKC WMIDADSRPK FRELIIEFSK MARDPQRYLV IQGDERMHLP SPTDSNFYRT LMDEEDMEDV VDADEYLIPQ QGFFHSPSTS RTPLISSLSC PLKEDSFLQR YSSDPTGTVT EDNIDDTFLP APEYVNQSVP KRPAGSVQNP VYHNQPLNPA PGRDPHYQNP HSNAMDNPEY LNTTHPDCVN SVLDGTALWA QKGNHQISLD NPDYQQDFFP KEAKSNGIFK GPAAENAEYL RVAPPSSEFI GA //