ID A0A3Q2I5Q7_HORSE Unreviewed; 1192 AA. AC A0A3Q2I5Q7; DT 10-APR-2019, integrated into UniProtKB/TrEMBL. DT 10-APR-2019, sequence version 1. DT 12-OCT-2022, entry version 18. DE RecName: Full=Receptor protein-tyrosine kinase {ECO:0000256|ARBA:ARBA00011902, ECO:0000256|PIRNR:PIRNR000619}; DE EC=2.7.10.1 {ECO:0000256|ARBA:ARBA00011902, ECO:0000256|PIRNR:PIRNR000619}; GN Name=EGFR {ECO:0000313|Ensembl:ENSECAP00000043331, GN ECO:0000313|VGNC:VGNC:17460}; OS Equus caballus (Horse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus. OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000043331, ECO:0000313|Proteomes:UP000002281}; RN [1] {ECO:0000313|Ensembl:ENSECAP00000043331, ECO:0000313|Proteomes:UP000002281} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000043331, RC ECO:0000313|Proteomes:UP000002281}; RX PubMed=19892987; DOI=10.1126/science.1178158; RG Broad Institute Genome Sequencing Platform; RG Broad Institute Whole Genome Assembly Team; RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F., RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O., RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T., RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T., RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S., RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G., RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R., RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A., RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J., RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.; RT "Genome sequence, comparative analysis, and population genetics of the RT domestic horse."; RL Science 326:865-867(2009). RN [2] {ECO:0000313|Ensembl:ENSECAP00000043331} RP IDENTIFICATION. RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000043331}; RG Ensembl; RL Submitted (JAN-2019) to UniProtKB. CC -!- CATALYTIC ACTIVITY: CC Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- CC [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA- CC COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, CC ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.1; CC Evidence={ECO:0000256|ARBA:ARBA00001171}; CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single- CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}. CC -!- SIMILARITY: Belongs to the protein kinase superfamily. Tyr protein CC kinase family. EGF receptor subfamily. {ECO:0000256|PIRNR:PIRNR000619}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR Ensembl; ENSECAT00000042132.1; ENSECAP00000043331.1; ENSECAG00000009952.3. DR VGNC; VGNC:17460; EGFR. DR GeneTree; ENSGT00940000155450; -. DR Proteomes; UP000002281; Chromosome 4. DR Bgee; ENSECAG00000009952; Expressed in trophoblast and 20 other tissues. DR ExpressionAtlas; A0A3Q2I5Q7; baseline. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0098590; C:plasma membrane region; IEA:UniProt. DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule. DR GO; GO:0004714; F:transmembrane receptor protein tyrosine kinase activity; IEA:UniProtKB-EC. DR GO; GO:0042127; P:regulation of cell population proliferation; IEA:UniProt. DR GO; GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway; IEA:InterPro. DR CDD; cd00064; FU; 3. DR Gene3D; 3.80.20.20; -; 2. DR Gene3D; 6.10.250.2930; -; 1. DR InterPro; IPR044912; Egfr_JX_dom. DR InterPro; IPR006211; Furin-like_Cys-rich_dom. DR InterPro; IPR006212; Furin_repeat. DR InterPro; IPR032778; GF_recep_IV. DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf. DR InterPro; IPR011009; Kinase-like_dom_sf. DR InterPro; IPR000719; Prot_kinase_dom. DR InterPro; IPR017441; Protein_kinase_ATP_BS. DR InterPro; IPR000494; Rcpt_L-dom. DR InterPro; IPR036941; Rcpt_L-dom_sf. DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom. DR InterPro; IPR008266; Tyr_kinase_AS. DR InterPro; IPR020635; Tyr_kinase_cat_dom. DR InterPro; IPR016245; Tyr_kinase_EGF/ERB/XmrK_rcpt. DR Pfam; PF00757; Furin-like; 1. DR Pfam; PF14843; GF_recep_IV; 1. DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1. DR Pfam; PF01030; Recep_L_domain; 2. DR PIRSF; PIRSF000619; TyrPK_EGF-R; 2. DR PRINTS; PR00109; TYRKINASE. DR SMART; SM00261; FU; 4. DR SMART; SM00219; TyrKc; 1. DR SUPFAM; SSF56112; SSF56112; 1. DR SUPFAM; SSF57184; SSF57184; 2. DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1. DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1. DR PROSITE; PS00109; PROTEIN_KINASE_TYR; 1. PE 3: Inferred from homology; KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PIRNR:PIRNR000619}; KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000256|PIRNR:PIRNR000619}; KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PIRNR:PIRNR000619}; KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, KW ECO:0000256|PIRNR:PIRNR000619}; KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553}; KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|PIRNR:PIRNR000619}; KW Reference proteome {ECO:0000313|Proteomes:UP000002281}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PIRNR:PIRNR000619}; KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, KW ECO:0000256|SAM:Phobius}; KW Tyrosine-protein kinase {ECO:0000256|ARBA:ARBA00023137, KW ECO:0000256|PIRNR:PIRNR000619}. FT SIGNAL 1..24 FT /evidence="ECO:0000256|SAM:SignalP" FT CHAIN 25..1192 FT /note="Receptor protein-tyrosine kinase" FT /evidence="ECO:0000256|SAM:SignalP" FT /id="PRO_5018752115" FT TRANSMEM 646..668 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT DOMAIN 712..979 FT /note="Protein kinase" FT /evidence="ECO:0000259|PROSITE:PS50011" FT REGION 1078..1122 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 1081..1095 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT ACT_SITE 837 FT /note="Proton acceptor" FT /evidence="ECO:0000256|PIRSR:PIRSR000619-1" FT BINDING 718..726 FT /ligand="ATP" FT /ligand_id="ChEBI:CHEBI:30616" FT /evidence="ECO:0000256|PIRSR:PIRSR000619-2" FT BINDING 745 FT /ligand="ATP" FT /ligand_id="ChEBI:CHEBI:30616" FT /evidence="ECO:0000256|PIRSR:PIRSR000619-2, FT ECO:0000256|PROSITE-ProRule:PRU10141" SQ SEQUENCE 1192 AA; 132850 MW; A131BB33E5064309 CRC64; MRHSGTVGAA LLVLLAAYFQ ASPALEEKKV CQGTSNRLTQ LGTFEDHFLS LQRMFNNCEV VLGNLEITYM QKNYDLSFLK TIQEVAGYVL IALNTVEKIP LENLQIIRGN VLYENTHALS VLSNYGANKV GLRELPMRNL QEILQGAVRF SNNPILCNME TIQWRDIVNS DFLSNMSVDF QNQLGSCQKC DPACPNGSCW GVGKENCQKL TKTICAQQCS GRCRGRSPSD CCHNQCAAGC TGPRESDCLV CRKFRDEATC KDTCPPLMLY NPTTYQMDVN PDGKYSFGAT CVKKCPRNYV VTDHGSCVRA CSSDSYEVEE DGVRKCKKCE GPCRKVCNGI GIGEFKDTLS INATNIKHFK NCTSISGDLH ILPVAFRGDS FTRTPPLDPK ELDILQTVKE ITGFLLIQAW PENRTDLHAF ENLEIIRGRT KQHGQFSLAV VGLDITSLGL RSLKEISDGD VIISGNRNLC YANTIKWKKL FGTSSQKTKI INNRSEKDCK TVGHVCNLLC SSEGCWGPEP RDCVSCQNVS RGKECVEKCN ILEGEPREFV ENSECIQCHP ECLPQAMNIT CTGRGPDNCI KCAHYIDGPH CVKTCPSGIM GENNTLVWKF ADANHVCHLC HPNCTYGCAG PGLEGCARNG PKIPSIATGI VGGLLLVVVV ALGIGLFLRR RHIVRKRTLR RLLQERELVE PLTPSGEAPN QALLRILKET EFKKIKVLGS GAFGTVYKGL WIPEGEKVKI PVAIKELREA TSPKANKEIL DEAYVMASVD NPHVCRLLGI CLTSTVQLIT QLMPFGCLLD YVREHKDNIG SQYLLNWCVQ IAKGMNYLED RRLVHRDLAA RNVLVKTPQH VKITDFGLAK LLGAEEKEYH AEGGKVPIKW MALESILHRI YTHQSDVWSY GVTVWELMTF GSKPYDGIPA SEISTILEKG ERLPQPPICT IDVYMIMVKC WMIDADSRPK FRELIIEFSK MARDPQRYLV IQGDERMHLP SPTDSNFYRT LMDEEDMEDV VDADEYLIPQ QGFFHSPSTS RTPLISSLSC PLKEDSFLQR YSSDPTGTVT EDNIDDTFLP APEYVNQSVP KRPAGSVQNP VYHNQPLNPA PGRDPHYQNP HSNAMDNPEY LNTTHPDCVN SVLDGTALWA QKGNHQISLD NPDYQQDFFP KEAKSNGIFK GPAAENAEYL RVAPPSSEFI GA //