ID   A0A3Q2GUM8_HORSE        Unreviewed;      1223 AA.
AC   A0A3Q2GUM8;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   05-JUN-2019, entry version 3.
DE   RecName: Full=Calcium-transporting ATPase {ECO:0000256|RuleBase:RU361146};
DE            EC=7.2.2.10 {ECO:0000256|RuleBase:RU361146};
GN   Name=ATP2B2 {ECO:0000313|Ensembl:ENSECAP00000024396,
GN   ECO:0000313|VGNC:VGNC:15654};
OS   Equus caballus (Horse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX   NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000024396, ECO:0000313|Proteomes:UP000002281};
RN   [1] {ECO:0000313|Ensembl:ENSECAP00000024396, ECO:0000313|Proteomes:UP000002281}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000024396,
RC   ECO:0000313|Proteomes:UP000002281};
RX   PubMed=19892987; DOI=10.1126/science.1178158;
RG   Broad Institute Genome Sequencing Platform;
RG   Broad Institute Whole Genome Assembly Team;
RA   Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA   Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H.,
RA   Distl O., Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N.,
RA   Penedo M.C.T., Raison J.M., Sharpe T., Vogel J., Andersson L.,
RA   Antczak D.F., Biagi T., Binns M.M., Chowdhary B.P., Coleman S.J.,
RA   Della Valle G., Fryc S., Guerin G., Hasegawa T., Hill E.W., Jurka J.,
RA   Kiialainen A., Lindgren G., Liu J., Magnani E., Mickelson J.R.,
RA   Murray J., Nergadze S.G., Onofrio R., Pedroni S., Piras M.F.,
RA   Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A., Searle S., Skow L.,
RA   Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J., Vaudin M.,
RA   White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT   "Genome sequence, comparative analysis, and population genetics of the
RT   domestic horse.";
RL   Science 326:865-867(2009).
RN   [2] {ECO:0000313|Ensembl:ENSECAP00000024396}
RP   IDENTIFICATION.
RC   STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000024396};
RG   Ensembl;
RL   Submitted (JAN-2019) to UniProtKB.
CC   -!- FUNCTION: This magnesium-dependent enzyme catalyzes the hydrolysis
CC       of ATP coupled with the transport of calcium.
CC       {ECO:0000256|RuleBase:RU361146}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + Ca(2+)(in) + H2O = ADP + Ca(2+)(out) + H(+) +
CC         phosphate; Xref=Rhea:RHEA:18105, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:29108, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=7.2.2.10;
CC         Evidence={ECO:0000256|RuleBase:RU361146};
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU361146};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU361146}.
CC   -!- SIMILARITY: Belongs to the cation transport ATPase (P-type)
CC       (TC 3.A.3) family. Type IIB subfamily.
CC       {ECO:0000256|RuleBase:RU361146}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU361146}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   Ensembl; ENSECAT00000044011; ENSECAP00000024396; ENSECAG00000023528.
DR   VGNC; VGNC:15654; ATP2B2.
DR   GeneTree; ENSGT00940000161461; -.
DR   Proteomes; UP000002281; Chromosome 16.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0006816; P:calcium ion transport; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.1110.10; -; 1.
DR   Gene3D; 3.40.50.1000; -; 1.
DR   InterPro; IPR030322; ATP2B2.
DR   InterPro; IPR022141; ATP_Ca_trans_C.
DR   InterPro; IPR006068; ATPase_P-typ_cation-transptr_C.
DR   InterPro; IPR004014; ATPase_P-typ_cation-transptr_N.
DR   InterPro; IPR023299; ATPase_P-typ_cyto_dom_N.
DR   InterPro; IPR018303; ATPase_P-typ_P_site.
DR   InterPro; IPR023298; ATPase_P-typ_TM_dom_sf.
DR   InterPro; IPR008250; ATPase_P-typ_transduc_dom_A_sf.
DR   InterPro; IPR036412; HAD-like_sf.
DR   InterPro; IPR023214; HAD_sf.
DR   InterPro; IPR006408; P-type_ATPase_IIB.
DR   InterPro; IPR001757; P_typ_ATPase.
DR   PANTHER; PTHR24093:SF377; PTHR24093:SF377; 1.
DR   Pfam; PF12424; ATP_Ca_trans_C; 1.
DR   Pfam; PF00689; Cation_ATPase_C; 1.
DR   Pfam; PF00690; Cation_ATPase_N; 1.
DR   SMART; SM00831; Cation_ATPase_N; 1.
DR   SUPFAM; SSF56784; SSF56784; 1.
DR   SUPFAM; SSF81653; SSF81653; 1.
DR   SUPFAM; SSF81660; SSF81660; 1.
DR   SUPFAM; SSF81665; SSF81665; 1.
DR   TIGRFAMs; TIGR01517; ATPase-IIB_Ca; 1.
DR   TIGRFAMs; TIGR01494; ATPase_P-type; 3.
DR   PROSITE; PS00154; ATPASE_E1_E2; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|RuleBase:RU361146,
KW   ECO:0000256|SAAS:SAAS00832164};
KW   Calcium {ECO:0000256|RuleBase:RU361146};
KW   Calcium transport {ECO:0000256|RuleBase:RU361146};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002281};
KW   Ion transport {ECO:0000256|RuleBase:RU361146};
KW   Membrane {ECO:0000256|RuleBase:RU361146,
KW   ECO:0000256|SAAS:SAAS00832173};
KW   Nucleotide-binding {ECO:0000256|RuleBase:RU361146,
KW   ECO:0000256|SAAS:SAAS00832168};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW   Transmembrane {ECO:0000256|RuleBase:RU361146,
KW   ECO:0000256|SAAS:SAAS00832175};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361146,
KW   ECO:0000256|SAAS:SAAS00832181};
KW   Transport {ECO:0000256|RuleBase:RU361146}.
FT   TRANSMEM     98    121       Helical. {ECO:0000256|RuleBase:RU361146}.
FT   TRANSMEM    151    170       Helical. {ECO:0000256|RuleBase:RU361146}.
FT   TRANSMEM    382    403       Helical. {ECO:0000256|RuleBase:RU361146}.
FT   TRANSMEM    423    449       Helical. {ECO:0000256|RuleBase:RU361146}.
FT   TRANSMEM    935    953       Helical. {ECO:0000256|RuleBase:RU361146}.
FT   TRANSMEM   1011   1031       Helical. {ECO:0000256|RuleBase:RU361146}.
FT   TRANSMEM   1043   1064       Helical. {ECO:0000256|RuleBase:RU361146}.
FT   DOMAIN       47    123       Cation_ATPase_N. {ECO:0000259|SMART:
FT                                SM00831}.
FT   REGION        1     24       Disordered. {ECO:0000256|MobiDB-lite:
FT                                A0A3Q2GUM8}.
FT   REGION      296    358       Disordered. {ECO:0000256|MobiDB-lite:
FT                                A0A3Q2GUM8}.
FT   REGION     1174   1223       Disordered. {ECO:0000256|MobiDB-lite:
FT                                A0A3Q2GUM8}.
FT   COMPBIAS      1     21       Polar. {ECO:0000256|MobiDB-lite:
FT                                A0A3Q2GUM8}.
FT   COMPBIAS   1175   1223       Polar. {ECO:0000256|MobiDB-lite:
FT                                A0A3Q2GUM8}.
SQ   SEQUENCE   1223 AA;  135019 MW;  7AFD67653CD5579D CRC64;
     MGDMTNSDFY SKNQRNESSH GGEFGCTMEE LRSLMELRGT EAVVKIKETY GDTEAICRRL
     KTSPVEGLPG TAPDLEKRKQ IFGQNFIPPK KPKTFLQLVW EALQDVTLII LEIAAIISLG
     LSFYHPPGEG NEGCATAQGG AEDEGEAEAG WIEGAAILLS VICVVLVTAF NDWSKEKQFR
     GLQSRIEQEQ KFTVVRAGQV VQIPVAEIVV GDIAQVKYGD LLPADGLFIQ GNDLKIDESS
     LTGESDQVRK SVDKDPMLLS GTHVMEGSGR MVVTAVGVNS QTGIIFTLLG AGGEEEEKKD
     KKGVKKGDGL QLPGKMQDGN VDASQSKAKQ QDGAAAMEMQ PLKSAEGGDA DDKKKANMHK
     KEKSVLQGKL TKLAVQIGKA GLVMSAITVI ILVLYFTVDT FVVNKKPWLP ECTPVYVQYF
     VKFFIIGVTV LVVAVPEGLP LAVTISLAYS VKKMMKDNNL VRHLDACETM GNATAICSDK
     TGTLTTNRMT VVQAYVGDVH YKEIPDPSSI NAKTMELLVN AIAINSAYTT KILPPEKEGA
     LPRQVGNKTE CGLLGFVLDL KQDYEPVRSQ MPEEKLYKVY TFNSVRKSMS TVIKLPDESF
     RMYSKGASEI VLKKCCKILS GAGEPRVFRP RDRDEMVKKV IEPMACDGLR TICVAYRDFP
     SSPEPDWDNE NDILNDLTCI CVVGIEDPVR PEVPEAIRKC QRAGITVRMV TGDNINTARA
     IAIKCGIIHP GEDFLCLEGK EFNRRIRNEK GEIEQERIDK IWPKLRVLAR SSPTDKHTLV
     KGIIDSTHTE QRQVVAVTGD GTNDGPALKK ADVGFAMGIA GTDVAKEASD IILTDDNFSS
     IVKAVMWGRN VYDSISKFLQ FQLTVNVVAV IVAFTGACIT QDSPLKAVQM LWVNLIMDTF
     ASLALATEPP TETLLLRKPY GRNKPLISRT MMKNILGHAV YQLTLIFTLL FVGEKMFQID
     SGRNAPLHSP PSEHYTIIFN TFVMMQLFNE VNARKIHGER NVFDGIFRNP IFCAIVLGTF
     AIQIVIVQFG GKPFSCSPLQ LDQWMWCIFI GLGELVWGQV IATIPTSRLK FLKEAGRLTQ
     KEEIPEEELN EDVEEIDHAE RELRRGQILW FRGLNRIQTQ IRVVKAFRSS LYEGLEKPES
     RTSIHNFMAH PEFRIEDSQP HIPLIDDTDL EEDAALKQNS SPPSSLNKNN SAIDSGINLT
     TDTSKSATSS SPGSPIHSLE TSL
//