ID A0A3Q1MV72_BOVIN Unreviewed; 507 AA. AC A0A3Q1MV72; DT 10-APR-2019, integrated into UniProtKB/TrEMBL. DT 10-APR-2019, sequence version 1. DT 27-NOV-2024, entry version 24. DE RecName: Full=Amino acid transporter {ECO:0000256|RuleBase:RU361216}; GN Name=SLC1A2 {ECO:0000313|Ensembl:ENSBTAP00000058834.1, GN ECO:0000313|VGNC:VGNC:34712}; OS Bos taurus (Bovine). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; OC Bovinae; Bos. OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000058834.1, ECO:0000313|Proteomes:UP000009136}; RN [1] {ECO:0000313|Ensembl:ENSBTAP00000058834.1, ECO:0000313|Proteomes:UP000009136} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000058834.1, RC ECO:0000313|Proteomes:UP000009136}; RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A., RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C., RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.; RT "ARS-UCD1.2."; RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSBTAP00000058834.1} RP IDENTIFICATION. RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000058834.1}; RG Ensembl; RL Submitted (AUG-2024) to UniProtKB. CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141, CC ECO:0000256|RuleBase:RU361216}; Multi-pass membrane protein CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU361216}. CC -!- SIMILARITY: Belongs to the dicarboxylate/amino acid:cation symporter CC (DAACS) (TC 2.A.23) family. {ECO:0000256|RuleBase:RU361216}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR RefSeq; XP_010811096.1; XM_010812794.2. DR RefSeq; XP_010821202.1; XM_010822900.2. DR AlphaFoldDB; A0A3Q1MV72; -. DR Ensembl; ENSBTAT00000075326.2; ENSBTAP00000058834.1; ENSBTAG00000012628.5. DR GeneID; 541119; -. DR CTD; 6506; -. DR VEuPathDB; HostDB:ENSBTAG00000012628; -. DR VGNC; VGNC:34712; SLC1A2. DR GeneTree; ENSGT00940000155379; -. DR Proteomes; UP000009136; Chromosome 15. DR Bgee; ENSBTAG00000012628; Expressed in prefrontal cortex and 42 other cell types or tissues. DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell. DR GO; GO:0015293; F:symporter activity; IEA:UniProtKB-UniRule. DR GO; GO:0070778; P:L-aspartate transmembrane transport; IGI:ARUK-UCL. DR GO; GO:0015813; P:L-glutamate transmembrane transport; IGI:ARUK-UCL. DR GO; GO:0070633; P:transepithelial transport; IGI:ARUK-UCL. DR GO; GO:0150104; P:transport across blood-brain barrier; IGI:ARUK-UCL. DR Gene3D; 1.10.3860.10; Sodium:dicarboxylate symporter; 2. DR InterPro; IPR050746; DAACS. DR InterPro; IPR001991; Na-dicarboxylate_symporter. DR InterPro; IPR018107; Na-dicarboxylate_symporter_CS. DR InterPro; IPR036458; Na:dicarbo_symporter_sf. DR PANTHER; PTHR11958:SF93; EXCITATORY AMINO ACID TRANSPORTER 2; 1. DR PANTHER; PTHR11958; SODIUM/DICARBOXYLATE SYMPORTER-RELATED; 1. DR Pfam; PF00375; SDF; 2. DR PRINTS; PR00173; EDTRNSPORT. DR SUPFAM; SSF118215; Proton glutamate symport protein; 1. DR PROSITE; PS00713; NA_DICARBOXYL_SYMP_1; 1. DR PROSITE; PS00714; NA_DICARBOXYL_SYMP_2; 1. PE 3: Inferred from homology; KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180}; KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361216}; KW Reference proteome {ECO:0000313|Proteomes:UP000009136}; KW Symport {ECO:0000256|ARBA:ARBA00022847, ECO:0000256|RuleBase:RU361216}; KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, KW ECO:0000256|RuleBase:RU361216}; KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, KW ECO:0000256|RuleBase:RU361216}; KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU361216}. FT TRANSMEM 56..78 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU361216" FT TRANSMEM 99..119 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU361216" FT TRANSMEM 131..153 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU361216" FT TRANSMEM 250..267 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU361216" FT TRANSMEM 287..309 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU361216" SQ SEQUENCE 507 AA; 54761 MW; 0CE2A48976C14C62 CRC64; MPALRGQRIP GDESMVSANN MPKQVEVRMH DSHLSAEEPK PRHLGLRLCD KLGKNLLLTL TVFGVILGAV CGGLLRLASP IHPDVVMLIA FPGDILMRML KMLILPLIIS SLITGLSGLD AKASGRLGTR AMVYYMSTTI IAAVLGVILV LAIHPGNPKL KKQLGPGKKN DEVSSLDAFL DLIRNLFPEN LVQACFQQIQ TVTKKVLVAP PSDEDGNATN AVLSLLNETV TEVPEETQVV IKKGLEFKDG MNVLGLIGFF IAFGIAMGKM GEQAKLMVEF FNILNEIVMK LVIMIMCAGT LPVTFRCLEE NLGIDKRVTR FVLPVGATIN MDGTALYEAV AAIFIAQMNG VVLDGGQIVT VSLTATLASV GAASIPSAGL VTMLLILTAV GLPTEDISLL VAVDWLLDRM RTSVNVVGDS FGAGIVYHLS KSELDTIDSQ HRVHEDIEMT KTQSIYDDLK NHRESNSNQC VYAAHNSVIV DECKVTLAAN GKSADCSVEE EPWKHEK //