ID A0A3Q1LSX9_BOVIN Unreviewed; 1095 AA. AC A0A3Q1LSX9; DT 10-APR-2019, integrated into UniProtKB/TrEMBL. DT 10-APR-2019, sequence version 1. DT 02-JUN-2021, entry version 14. DE SubName: Full=Formin like 2 {ECO:0000313|Ensembl:ENSBTAP00000063529}; GN Name=FMNL2 {ECO:0000313|Ensembl:ENSBTAP00000063529, GN ECO:0000313|VGNC:VGNC:29047}; OS Bos taurus (Bovine). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; OC Bovinae; Bos. OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000063529, ECO:0000313|Proteomes:UP000009136}; RN [1] {ECO:0000313|Ensembl:ENSBTAP00000063529, ECO:0000313|Proteomes:UP000009136} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000063529, RC ECO:0000313|Proteomes:UP000009136}; RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A., RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C., RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.; RT "ARS-UCD1.2."; RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSBTAP00000063529} RP IDENTIFICATION. RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000063529}; RG Ensembl; RL Submitted (JAN-2019) to UniProtKB. CC -!- SIMILARITY: Belongs to the formin homology family. CC {ECO:0000256|ARBA:ARBA00023449}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR SMR; A0A3Q1LSX9; -. DR Ensembl; ENSBTAT00000073284; ENSBTAP00000063529; ENSBTAG00000026851. DR VGNC; VGNC:29047; FMNL2. DR GeneTree; ENSGT00940000155515; -. DR OMA; MMPGFSP; -. DR Reactome; R-BTA-5663220; RHO GTPases Activate Formins. DR Proteomes; UP000009136; Chromosome 2. DR ExpressionAtlas; A0A3Q1LSX9; baseline and differential. DR GO; GO:0005829; C:cytosol; IBA:GO_Central. DR GO; GO:0051015; F:actin filament binding; IBA:GO_Central. DR GO; GO:0031267; F:small GTPase binding; IEA:InterPro. DR GO; GO:0016477; P:cell migration; IBA:GO_Central. DR GO; GO:0030866; P:cortical actin cytoskeleton organization; IBA:GO_Central. DR GO; GO:0008360; P:regulation of cell shape; IBA:GO_Central. DR Gene3D; 1.20.58.2220; -; 1. DR InterPro; IPR016024; ARM-type_fold. DR InterPro; IPR015425; FH2_Formin. DR InterPro; IPR042201; FH2_Formin_sf. DR InterPro; IPR010472; FH3_dom. DR InterPro; IPR043592; FMNL. DR InterPro; IPR027656; FMNL2. DR InterPro; IPR014768; GBD/FH3_dom. DR InterPro; IPR010473; GTPase-bd. DR PANTHER; PTHR45857; PTHR45857; 1. DR PANTHER; PTHR45857:SF5; PTHR45857:SF5; 1. DR Pfam; PF06367; Drf_FH3; 1. DR Pfam; PF06371; Drf_GBD; 2. DR Pfam; PF02181; FH2; 1. DR SMART; SM01139; Drf_FH3; 1. DR SMART; SM01140; Drf_GBD; 1. DR SMART; SM00498; FH2; 1. DR SUPFAM; SSF48371; SSF48371; 1. DR PROSITE; PS51444; FH2; 1. DR PROSITE; PS51232; GBD_FH3; 1. PE 3: Inferred from homology; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Reference proteome {ECO:0000313|Proteomes:UP000009136}. FT DOMAIN 23..469 FT /note="GBD/FH3" FT /evidence="ECO:0000259|PROSITE:PS51232" FT DOMAIN 617..1008 FT /note="FH2" FT /evidence="ECO:0000259|PROSITE:PS51444" FT REGION 521..602 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COILED 93..113 FT /evidence="ECO:0000256|SAM:Coils" FT COILED 381..478 FT /evidence="ECO:0000256|SAM:Coils" FT COILED 897..917 FT /evidence="ECO:0000256|SAM:Coils" FT COILED 982..1013 FT /evidence="ECO:0000256|SAM:Coils" FT COMPBIAS 521..537 FT /note="Pro residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 546..600 FT /note="Pro residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 1095 AA; 124214 MW; 410E9DE51208AB03 CRC64; MGNAGSMDSQ QTDFRAHNVP LKLPMPEPGE LEERFAIVLN AMNLPPDKAR LLRQYDNEKK WELICDQERF QVKNPPHTYI QKLKGYLDPA VTRKKFRRRV QESTQVLREL EISLRTNHIG WVREFLNEEN KGLDVLVEYL SFAQYAVTFD FESVESTVES SVDKSKPWSR SIEDLHRGSN LPSPVGNSVS RSGRHSALRY NTLPSRRTLK NSRLVSKKDD VHVCIMCLRA IMNYQYGFNM VMSHPHAVNE IALSLNNKNP RTKALVLELL AAVCLVRGGH EIILSAFDNF KEVCGEKQRF EKLMEHFRNE DNNIDFMVAS MQFINIVVHS VEDMNFRVHL QYEFTKLGLD EYLDKLKHTE SDKLQVQIQA YLDNVFDVGA LLEDAETKNA ALERVEELEE NISHLSEKLQ DTENEAMSKI VELEKQLMQR NKELDVVREI YKDANTQVHT LRKMVKEKEE AIQRQSTLEK KIHELEKQGT IKIQKKGDGD IAILPVVASG TLPTGSEVAV GNFVGPVMGA PSSGPLPPPP PPLPLSSDAP EAVQNGPATP PVPPPPPPPP PPPPPPPPPP PPPLPGPAAE TLPAPPLPPP PPPSAPPLPG TSSPTVVFNS GLAAVKIKKP IKTKFRMPVF NWVALKPNQI NGTVFNEIDD ERILEDLNVD EFEEIFKTKA QGPAIDLSSS KQKITQKGSN KVTLLEANRA KNLAITLRKA GKTAEEICKA IHVFDLKTLP VDFVECLMRF LPTENEVKVL RLYERERKPL ENLSDEDRFM MQFSKIERLM QKMTIMAFIG NFTESIQMLT PQLHSIIAAS VSIKSSQKLK KILEIILALG NYMNSSKRGA VYGFKLQSLD LLLDTKSTDR KQTLLHYISN VVKEKYQQVS LFYNELHYVE KAAAVSLENV LLDVKELQRG MDLTKREYTM HDHNTLLKEF IFNNEGKLKK LQDDAKIAQD AFDDVVKYFG ENPKTTPPSV FFPVFVRFVK AYKQAEEENE LRKKQEQALM EKLLEQEALL EQQDPKSPSH KSKRQQQELI AELRRRQVKD NRHVYEGKDG AIEDIITALK KNNITKFPNV HSRVRISSST PVVEDTQSWQ ASLFT //