ID A0A3Q0QZW9_AMPCI Unreviewed; 205 AA. AC A0A3Q0QZW9; DT 10-APR-2019, integrated into UniProtKB/TrEMBL. DT 10-APR-2019, sequence version 1. DT 12-AUG-2020, entry version 8. DE RecName: Full=Insulin-induced gene protein {ECO:0000256|RuleBase:RU241113}; OS Amphilophus citrinellus (Midas cichlid) (Cichlasoma citrinellum). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; New World cichlids; OC Cichlasomatinae; Heroini; Amphilophus. OX NCBI_TaxID=61819 {ECO:0000313|Ensembl:ENSACIP00000005239}; RN [1] {ECO:0000313|Ensembl:ENSACIP00000005239} RP NUCLEOTIDE SEQUENCE. RA Franchini P.; RL Submitted (AUG-2014) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSACIP00000005239} RP IDENTIFICATION. RG Ensembl; RL Submitted (JAN-2019) to UniProtKB. CC -!- FUNCTION: Mediates feedback control of cholesterol synthesis. CC {ECO:0000256|RuleBase:RU241113}. CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane CC {ECO:0000256|ARBA:ARBA00004477, ECO:0000256|RuleBase:RU241113}; Multi- CC pass membrane protein {ECO:0000256|ARBA:ARBA00004477, CC ECO:0000256|RuleBase:RU241113}. Membrane CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein CC {ECO:0000256|ARBA:ARBA00004141}. CC -!- SIMILARITY: Belongs to the INSIG family. CC {ECO:0000256|ARBA:ARBA00007475, ECO:0000256|RuleBase:RU241113}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR Ensembl; ENSACIT00000005404; ENSACIP00000005239; ENSACIG00000004028. DR GeneTree; ENSGT00580000081600; -. DR Proteomes; UP000261340; Whole Genome Shotgun Assembly. DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0008203; P:cholesterol metabolic process; IEA:UniProtKB-KW. DR InterPro; IPR025929; INSIG_fam. DR PANTHER; PTHR15301; PTHR15301; 1. DR Pfam; PF07281; INSIG; 1. PE 3: Inferred from homology; KW Cholesterol metabolism {ECO:0000256|ARBA:ARBA00022548, KW ECO:0000256|RuleBase:RU241113}; KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824, KW ECO:0000256|RuleBase:RU241113}; KW Lipid metabolism {ECO:0000256|RuleBase:RU241113}; KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU241113}; KW Steroid metabolism {ECO:0000256|ARBA:ARBA00023221, KW ECO:0000256|RuleBase:RU241113}; KW Sterol metabolism {ECO:0000256|ARBA:ARBA00023166}; KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, KW ECO:0000256|RuleBase:RU241113}; KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, KW ECO:0000256|RuleBase:RU241113}. FT TRANSMEM 12..29 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU241113" FT TRANSMEM 49..68 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU241113" FT TRANSMEM 111..128 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU241113" FT TRANSMEM 135..154 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU241113" FT TRANSMEM 166..186 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU241113" SQ SEQUENCE 205 AA; 22583 MW; 10788A6F29EB3AF4 CRC64; HSAGSSVSKR GGAMLFSVGV FLALVLNLLQ VQRNVTLFPP DVISSIFSSA WWVPPCCGTA AAMIGLLYPC IDSRLGEPHK FKREWSSVMR CVAVFVGINH ASAKVDFANN VQLSLTLAAL SIGLWWTFDR SRSGFGLGVC IAFLGTLATQ LLVYNGVFQY TSPDFLYIRS WLPCIFFAGV ITMGNIGRQL ALYEYKFIQE KSHQD //