ID A0A3Q0L3L9_VIBVU Unreviewed; 299 AA. AC A0A3Q0L3L9; DT 13-FEB-2019, integrated into UniProtKB/TrEMBL. DT 13-FEB-2019, sequence version 1. DT 29-MAY-2024, entry version 20. DE RecName: Full=Hydrogen peroxide-inducible genes activator {ECO:0000256|ARBA:ARBA00040580}; GN OrderedLocusNames=VV1_1375 {ECO:0000313|EMBL:AAO09824.1}; OS Vibrio vulnificus (strain CMCP6). OC Bacteria; Pseudomonadota; Gammaproteobacteria; Vibrionales; Vibrionaceae; OC Vibrio. OX NCBI_TaxID=216895 {ECO:0000313|EMBL:AAO09824.1, ECO:0000313|Proteomes:UP000002275}; RN [1] {ECO:0000313|Proteomes:UP000002275} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=CMCP6 {ECO:0000313|Proteomes:UP000002275}; RA Rhee J.H., Kim S.Y., Chung S.S., Kim J.J., Moon Y.H., Jeong H., Choy H.E.; RT "Complete genome sequence of Vibrio vulnificus CMCP6."; RL Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|EMBL:AAO09824.1, ECO:0000313|Proteomes:UP000002275} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=CMCP6 {ECO:0000313|EMBL:AAO09824.1, RC ECO:0000313|Proteomes:UP000002275}; RX PubMed=14500463; DOI=10.1128/IAI.71.10.5461-5471.2003; RA Kim Y.R., Lee S.E., Kim C.M., Kim S.Y., Shin E.K., Shin D.H., Chung S.S., RA Choy H.E., Progulske-Fox A., Hillman J.D., Handfield M., Rhee J.H.; RT "Characterization and pathogenic significance of Vibrio vulnificus antigens RT preferentially expressed in septicemic patients."; RL Infect. Immun. 71:5461-5471(2003). RN [3] {ECO:0000313|EMBL:AAO09824.1, ECO:0000313|Proteomes:UP000002275} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=CMCP6 {ECO:0000313|EMBL:AAO09824.1, RC ECO:0000313|Proteomes:UP000002275}; RX PubMed=21245845; DOI=10.1038/msb.2010.115; RA Kim H.U., Kim S.Y., Jeong H., Kim T.Y., Kim J.J., Choy H.E., Yi K.Y., RA Rhee J.H., Lee S.Y.; RT "Integrative genome-scale metabolic analysis of Vibrio vulnificus for drug RT targeting and discovery."; RL Mol. Syst. Biol. 7:460-460(2011). CC -!- SIMILARITY: Belongs to the LysR transcriptional regulatory family. CC {ECO:0000256|ARBA:ARBA00009437}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AE016795; AAO09824.1; -; Genomic_DNA. DR RefSeq; WP_011079350.1; NC_004459.3. DR AlphaFoldDB; A0A3Q0L3L9; -. DR KEGG; vvu:VV1_1375; -. DR Proteomes; UP000002275; Chromosome 1. DR GO; GO:0032993; C:protein-DNA complex; IEA:TreeGrafter. DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro. DR CDD; cd08411; PBP2_OxyR; 1. DR Gene3D; 3.40.190.10; Periplasmic binding protein-like II; 2. DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1. DR InterPro; IPR005119; LysR_subst-bd. DR InterPro; IPR000847; Tscrpt_reg_HTH_LysR. DR InterPro; IPR036388; WH-like_DNA-bd_sf. DR InterPro; IPR036390; WH_DNA-bd_sf. DR PANTHER; PTHR30346:SF26; HYDROGEN PEROXIDE-INDUCIBLE GENES ACTIVATOR; 1. DR PANTHER; PTHR30346; TRANSCRIPTIONAL DUAL REGULATOR HCAR-RELATED; 1. DR Pfam; PF00126; HTH_1; 1. DR Pfam; PF03466; LysR_substrate; 1. DR PRINTS; PR00039; HTHLYSR. DR SUPFAM; SSF53850; Periplasmic binding protein-like II; 1. DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1. DR PROSITE; PS50931; HTH_LYSR; 1. PE 3: Inferred from homology; FT DOMAIN 1..58 FT /note="HTH lysR-type" FT /evidence="ECO:0000259|PROSITE:PS50931" SQ SEQUENCE 299 AA; 33165 MW; 03CDC64A07521CFC CRC64; MNIRDFEYLV ALAEHKHFRK AAEACFVSQP TLSGQIRKLE EEIGTTLLER SSRRVLFTDA GLQLVEQAKN ILKEVKTFKE MASGQSGAMT GPMHIGFIPT LGPYLLPKIV PQLKERFPEL ELFLHEAQTQ QLVRQLEDGK LDCLVLASVA ETEPFKEIEV YNEPLSVAVP CHHEWAALEQ LDMLELNGKT VLALGDGHCL RDQALGFCFA AGARDDERFK ATSLETLRNM VAAGAGITLL PELSVPKEKQ KDGVCYIKAV NPVPSRTIVV VYRPGSPLRA RFEQLAATIK ELLVSGSEQ //