ID A0A3Q0J3B3_DIACI Unreviewed; 1056 AA. AC A0A3Q0J3B3; DT 13-FEB-2019, integrated into UniProtKB/TrEMBL. DT 13-FEB-2019, sequence version 1. DT 03-MAY-2023, entry version 16. DE RecName: Full=exodeoxyribonuclease III {ECO:0000256|ARBA:ARBA00012115}; DE EC=3.1.11.2 {ECO:0000256|ARBA:ARBA00012115}; GN Name=LOC108251834 {ECO:0000313|RefSeq:XP_026682906.1}; OS Diaphorina citri (Asian citrus psyllid). OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; OC Neoptera; Paraneoptera; Hemiptera; Sternorrhyncha; Psylloidea; Liviidae; OC Diaphorina. OX NCBI_TaxID=121845 {ECO:0000313|Proteomes:UP000079169, ECO:0000313|RefSeq:XP_026682906.1}; RN [1] {ECO:0000313|RefSeq:XP_026682906.1} RP IDENTIFICATION. RG RefSeq; RL Submitted (JAN-2023) to UniProtKB. CC -!- CATALYTIC ACTIVITY: CC Reaction=Exonucleolytic cleavage in the 3'- to 5'-direction to yield CC nucleoside 5'-phosphates.; EC=3.1.11.2; CC Evidence={ECO:0000256|ARBA:ARBA00000493}; CC -!- SIMILARITY: Belongs to the DNA repair enzymes AP/ExoA family. CC {ECO:0000256|ARBA:ARBA00007092}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR RefSeq; XP_026682906.1; XM_026827105.1. DR AlphaFoldDB; A0A3Q0J3B3; -. DR STRING; 121845.A0A3Q0J3B3; -. DR KEGG; dci:108251834; -. DR OrthoDB; 161558at2759; -. DR Proteomes; UP000079169; Unplaced. DR GO; GO:0004518; F:nuclease activity; IEA:InterPro. DR GO; GO:0006281; P:DNA repair; IEA:InterPro. DR CDD; cd09087; Ape1-like_AP-endo; 1. DR Gene3D; 3.60.10.10; Endonuclease/exonuclease/phosphatase; 1. DR InterPro; IPR004808; AP_endonuc_1. DR InterPro; IPR036691; Endo/exonu/phosph_ase_sf. DR InterPro; IPR005135; Endo/exonuclease/phosphatase. DR PANTHER; PTHR22748; AP ENDONUCLEASE; 1. DR PANTHER; PTHR22748:SF6; DNA-(APURINIC OR APYRIMIDINIC SITE) ENDONUCLEASE; 1. DR Pfam; PF03372; Exo_endo_phos; 1. DR SUPFAM; SSF56219; DNase I-like; 1. DR TIGRFAMs; TIGR00195; exoDNase_III; 1. DR TIGRFAMs; TIGR00633; xth; 1. DR PROSITE; PS51435; AP_NUCLEASE_F1_4; 1. PE 3: Inferred from homology; KW Reference proteome {ECO:0000313|Proteomes:UP000079169}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1..22 FT /evidence="ECO:0000256|SAM:SignalP" FT CHAIN 23..1056 FT /note="exodeoxyribonuclease III" FT /evidence="ECO:0000256|SAM:SignalP" FT /id="PRO_5018152902" FT DOMAIN 773..1047 FT /note="Endonuclease/exonuclease/phosphatase" FT /evidence="ECO:0000259|Pfam:PF03372" FT REGION 307..326 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 421..518 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 539..571 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 480..501 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 554..571 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 1056 AA; 120817 MW; EA8491196BCB1610 CRC64; MDLFRLGNEV IVLVLDLLCV YCTLVSDNSS VPCLIQDNGA ILSSKPPFPS LKYSYSTFRW NETRPTTMFV TINRRHEYDF LYSDRECQVV RKKRVSPSRE MHLKDILATF DSEDGAIVVD ASRRDRKELK EPTLPEDLFD DLECESLHVS ELKDENDENI GAQSQVIHDS LFKHRNRTES HSPEPLKMTN PREDYDFFSD FNVKPIRKTS ANKSVKADDL KNVLNLFASE DGGYVPVLKK SVEISQEKEP TLPAILMGNS ELHVSEMEEN NDDSNIKLHR EVKSDVNEDQ ESNIKIVRDL DSEVINSEQT VDRTESSEDK YSKSQHGDLN DIYFPSNLYH KKTFKTTAGS SENILLKGLL MNRKSTQPRH SISTSKNRSP TQNEIDMIVE NFISVQRKFS LNTVRPVTHF LNVSNEESYE KYTFRKRKGK TKTTRIKTTK YSDKSTKRRG RPKKTTTPSG GIISSPSKNT RKHDKKYTTN SESIQTSVSN IRDSTSRNLK TKSVNIEDKS ESASTATLKT IGKEDKDFIS RPVKSSRVST KIQLDHSVKK SQKQGLTKYE SQPSSTSTST DVLPAHKMSL APERKIAQFN NRNKLVLLHT KTTHVKTVPS ENVQNTKGKF ELLKEIKFER TGSEDTSEDV EESGFFTVEP IPDSNLYNEW EYRPPKRKVK TSTFSLKSLK NLDDKLSYIR EVCGEHMPVN VTKKASRKNV FSFKLNEIHV GTGKIENRLG CDSSNETSYA EVEEVPIIDF NDPFRILEHK RRQDQYPWNF KIGSWNVNGI RAWSQKDGFS FMRQHDLNVF CIQEIRCPLE KLPECPEGYH AFWFPGTRQG YAGVAVLSKT KPVRVTHGFS MKVGGVVHTH GFNRGSNEHG SDMESGPSHP ELTTIQYADA SGIDDGRVMT VEYEQFYLVN VYAPAAKEDL SMLSVKLLWN SFLRGHLKSL NEIKPVVLAG DLNVAHNHID VALPLTNLGK SGFTIQERNY FSNFLDLGFL DVHRHLYPNH RIYTYWPYYD RPSKMKGWRL DYFLISKQLK SHLSDLEIHG DVEGSDHAPQ ILYLNL //