ID A0A3P9B2J2_9CICH Unreviewed; 289 AA. AC A0A3P9B2J2; DT 13-FEB-2019, integrated into UniProtKB/TrEMBL. DT 13-FEB-2019, sequence version 1. DT 12-AUG-2020, entry version 8. DE RecName: Full=Aldo_ket_red domain-containing protein {ECO:0000259|Pfam:PF00248}; OS Maylandia zebra (zebra mbuna). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids; OC Pseudocrenilabrinae; Haplochromini; Maylandia; Maylandia zebra complex. OX NCBI_TaxID=106582 {ECO:0000313|Ensembl:ENSMZEP00005004130}; RN [1] {ECO:0000313|Ensembl:ENSMZEP00005004130} RP NUCLEOTIDE SEQUENCE. RX PubMed=25186727; DOI=10.1038/nature13726; RA Brawand D., Wagner C.E., Li Y.I., Malinsky M., Keller I., Fan S., RA Simakov O., Ng A.Y., Lim Z.W., Bezault E., Turner-Maier J., Johnson J., RA Alcazar R., Noh H.J., Russell P., Aken B., Alfoldi J., Amemiya C., RA Azzouzi N., Baroiller J.F., Barloy-Hubler F., Berlin A., Bloomquist R., RA Carleton K.L., Conte M.A., D'Cotta H., Eshel O., Gaffney L., Galibert F., RA Gante H.F., Gnerre S., Greuter L., Guyon R., Haddad N.S., Haerty W., RA Harris R.M., Hofmann H.A., Hourlier T., Hulata G., Jaffe D.B., Lara M., RA Lee A.P., MacCallum I., Mwaiko S., Nikaido M., Nishihara H., RA Ozouf-Costaz C., Penman D.J., Przybylski D., Rakotomanga M., Renn S.C.P., RA Ribeiro F.J., Ron M., Salzburger W., Sanchez-Pulido L., Santos M.E., RA Searle S., Sharpe T., Swofford R., Tan F.J., Williams L., Young S., Yin S., RA Okada N., Kocher T.D., Miska E.A., Lander E.S., Venkatesh B., Fernald R.D., RA Meyer A., Ponting C.P., Streelman J.T., Lindblad-Toh K., Seehausen O., RA Di Palma F.; RT "The genomic substrate for adaptive radiation in African cichlid fish."; RL Nature 513:375-381(2014). RN [2] {ECO:0000313|Ensembl:ENSMZEP00005004130} RP IDENTIFICATION. RG Ensembl; RL Submitted (DEC-2018) to UniProtKB. CC -!- SIMILARITY: Belongs to the aldo/keto reductase family. CC {ECO:0000256|ARBA:ARBA00007905}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR RefSeq; XP_004554395.1; XM_004554338.2. DR Ensembl; ENSMZET00005004301; ENSMZEP00005004130; ENSMZEG00005003180. DR GeneID; 101483021; -. DR KEGG; mze:101483021; -. DR GeneTree; ENSGT00940000164916; -. DR Proteomes; UP000265160; LG3. DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro. DR CDD; cd06660; Aldo_ket_red; 1. DR Gene3D; 3.20.20.100; -; 1. DR InterPro; IPR018170; Aldo/ket_reductase_CS. DR InterPro; IPR020471; Aldo/keto_reductase. DR InterPro; IPR023210; NADP_OxRdtase_dom. DR InterPro; IPR036812; NADP_OxRdtase_dom_sf. DR PANTHER; PTHR43827; PTHR43827; 1. DR Pfam; PF00248; Aldo_ket_red; 1. DR PIRSF; PIRSF000097; AKR; 1. DR PRINTS; PR00069; ALDKETRDTASE. DR SUPFAM; SSF51430; SSF51430; 1. DR PROSITE; PS00798; ALDOKETO_REDUCTASE_1; 1. PE 3: Inferred from homology; KW Reference proteome {ECO:0000313|Proteomes:UP000265160}. FT DOMAIN 20..275 FT /note="Aldo_ket_red" FT /evidence="ECO:0000259|Pfam:PF00248" FT ACT_SITE 54 FT /note="Proton donor" FT /evidence="ECO:0000256|PIRSR:PIRSR000097-1" FT BINDING 115 FT /note="Substrate" FT /evidence="ECO:0000256|PIRSR:PIRSR000097-2" FT SITE 83 FT /note="Lowers pKa of active site Tyr" FT /evidence="ECO:0000256|PIRSR:PIRSR000097-3" SQ SEQUENCE 289 AA; 31662 MW; 7C44D0EFA88D93D5 CRC64; MSSTTTSSVT LNTGVQMPLL GLGTYKLHGS EEVYRAVDAA LAAGYRAFDS AAVYRNEADM GRSLRELLHK HGLTRQDVFI TSKLGPKDQG ERAMEGALHS LSQLDLGYID LYLIHWPGTQ GLAVADQSNP GNRAQSWATL EELHGQGKLK AIGVSNYTVA HMRELMQSCK VPPAVLQVEF HPRLCQAELK SVCEEYGVCF QAYSSLGQGD LVTDPVVLEV AKQYQRTPAQ VLLRWAVQQG VAVLPKSSNA DRIQENARLF DFTLSDADMD RLSALDCGQK YCWDPSGVA //