ID   A0A3P9B138_9CICH        Unreviewed;       817 AA.
AC   A0A3P9B138;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   03-JUL-2019, entry version 5.
DE   RecName: Full=Fibroblast growth factor receptor {ECO:0000256|PIRNR:PIRNR000628};
DE            EC=2.7.10.1 {ECO:0000256|PIRNR:PIRNR000628};
OS   Maylandia zebra (zebra mbuna).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Haplochromini; Maylandia;
OC   Maylandia zebra complex.
OX   NCBI_TaxID=106582 {ECO:0000313|Ensembl:ENSMZEP00005003660, ECO:0000313|Proteomes:UP000265160};
RN   [1] {ECO:0000313|Ensembl:ENSMZEP00005003660, ECO:0000313|Proteomes:UP000265160}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=25186727; DOI=10.1038/nature13726;
RA   Brawand D., Wagner C.E., Li Y.I., Malinsky M., Keller I., Fan S.,
RA   Simakov O., Ng A.Y., Lim Z.W., Bezault E., Turner-Maier J.,
RA   Johnson J., Alcazar R., Noh H.J., Russell P., Aken B., Alfoldi J.,
RA   Amemiya C., Azzouzi N., Baroiller J.F., Barloy-Hubler F., Berlin A.,
RA   Bloomquist R., Carleton K.L., Conte M.A., D'Cotta H., Eshel O.,
RA   Gaffney L., Galibert F., Gante H.F., Gnerre S., Greuter L., Guyon R.,
RA   Haddad N.S., Haerty W., Harris R.M., Hofmann H.A., Hourlier T.,
RA   Hulata G., Jaffe D.B., Lara M., Lee A.P., MacCallum I., Mwaiko S.,
RA   Nikaido M., Nishihara H., Ozouf-Costaz C., Penman D.J., Przybylski D.,
RA   Rakotomanga M., Renn S.C.P., Ribeiro F.J., Ron M., Salzburger W.,
RA   Sanchez-Pulido L., Santos M.E., Searle S., Sharpe T., Swofford R.,
RA   Tan F.J., Williams L., Young S., Yin S., Okada N., Kocher T.D.,
RA   Miska E.A., Lander E.S., Venkatesh B., Fernald R.D., Meyer A.,
RA   Ponting C.P., Streelman J.T., Lindblad-Toh K., Seehausen O.,
RA   Di Palma F.;
RT   "The genomic substrate for adaptive radiation in African cichlid
RT   fish.";
RL   Nature 513:375-381(2014).
RN   [2] {ECO:0000313|Ensembl:ENSMZEP00005003660}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (DEC-2018) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-
CC         tyrosyl-[protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136,
CC         Rhea:RHEA-COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216;
CC         EC=2.7.10.1; Evidence={ECO:0000256|PIRNR:PIRNR000628,
CC         ECO:0000256|SAAS:SAAS01168082};
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily. Tyr protein
CC       kinase family. Fibroblast growth factor receptor subfamily.
CC       {ECO:0000256|PIRNR:PIRNR000628}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   Ensembl; ENSMZET00005003813; ENSMZEP00005003660; ENSMZEG00005002787.
DR   GeneTree; ENSGT00940000159880; -.
DR   Proteomes; UP000265160; LG19.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0005007; F:fibroblast growth factor-activated receptor activity; IEA:InterPro.
DR   GO; GO:0008284; P:positive regulation of cell population proliferation; IEA:InterPro.
DR   Gene3D; 2.60.40.10; -; 3.
DR   InterPro; IPR016248; FGF_rcpt_fam.
DR   InterPro; IPR041159; FGFR_TM.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR013098; Ig_I-set.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR003598; Ig_sub2.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   InterPro; IPR017441; Protein_kinase_ATP_BS.
DR   InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR   InterPro; IPR008266; Tyr_kinase_AS.
DR   InterPro; IPR020635; Tyr_kinase_cat_dom.
DR   Pfam; PF18123; FGFR3_TM; 1.
DR   Pfam; PF07679; I-set; 1.
DR   Pfam; PF07714; Pkinase_Tyr; 1.
DR   PIRSF; PIRSF000628; FGFR; 1.
DR   PRINTS; PR00109; TYRKINASE.
DR   SMART; SM00409; IG; 3.
DR   SMART; SM00408; IGc2; 3.
DR   SMART; SM00219; TyrKc; 1.
DR   SUPFAM; SSF48726; SSF48726; 3.
DR   SUPFAM; SSF56112; SSF56112; 1.
DR   PROSITE; PS50835; IG_LIKE; 3.
DR   PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|PIRNR:PIRNR000628,
KW   ECO:0000256|SAAS:SAAS00600564};
KW   Complete proteome {ECO:0000313|Proteomes:UP000265160};
KW   Disulfide bond {ECO:0000256|SAAS:SAAS00916669};
KW   Immunoglobulin domain {ECO:0000256|SAAS:SAAS00941986};
KW   Kinase {ECO:0000256|PIRNR:PIRNR000628, ECO:0000256|SAAS:SAAS00601152};
KW   Membrane {ECO:0000256|PIRNR:PIRNR000628,
KW   ECO:0000256|SAAS:SAAS00602125, ECO:0000256|SAM:Phobius};
KW   Nucleotide-binding {ECO:0000256|PIRNR:PIRNR000628,
KW   ECO:0000256|SAAS:SAAS00600689};
KW   Receptor {ECO:0000256|PIRNR:PIRNR000628,
KW   ECO:0000256|SAAS:SAAS00600436};
KW   Reference proteome {ECO:0000313|Proteomes:UP000265160};
KW   Repeat {ECO:0000256|SAAS:SAAS00295312};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transferase {ECO:0000256|PIRNR:PIRNR000628,
KW   ECO:0000256|SAAS:SAAS00601608};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00600943,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00602683,
KW   ECO:0000256|SAM:Phobius};
KW   Tyrosine-protein kinase {ECO:0000256|PIRNR:PIRNR000628,
KW   ECO:0000256|SAAS:SAAS00582553}.
FT   SIGNAL        1     41       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        42    817       Fibroblast growth factor receptor.
FT                                {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5018227582.
FT   TRANSMEM    381    401       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       51    140       Ig-like. {ECO:0000259|PROSITE:PS50835}.
FT   DOMAIN      155    254       Ig-like. {ECO:0000259|PROSITE:PS50835}.
FT   DOMAIN      263    352       Ig-like. {ECO:0000259|PROSITE:PS50835}.
FT   DOMAIN      477    756       Protein kinase. {ECO:0000259|PROSITE:
FT                                PS50011}.
FT   REGION      781    817       Disordered. {ECO:0000256|MobiDB-lite:
FT                                A0A3P9B138}.
FT   ACT_SITE    622    622       Proton acceptor. {ECO:0000256|PIRSR:
FT                                PIRSR000628-1}.
SQ   SEQUENCE   817 AA;  91504 MW;  C5D97EDE06C62DB1 CRC64;
     MLSKLESGLA ALRLTSSPRG MTALWCSLWL SLLLPLTVVP AGLPTAQPTD PVSSETAFLE
     DYVLGIGDTL EMSCDPEEQE DHTEPIVWLK DGAGLVPCNR IRLGQRILRI INVSYDDSGV
     YSCHLARSNT LLSNYTIRVT DSLSSGDDED YDEDPEGAEA PYWTRPERMD KKLLAVPAAN
     TVKFRCAASG NPPPTIHWLK NGKEFKGEQR MGGIKLRHQQ WSLVMESAVP SDRGNYTCVV
     QNKYGSISHT YQLDVLERSP HRPILQAGLP ANQTVVVGSN VEFHCKVYSD AQPHIQWLKH
     IEVNGSRLGP DGVPYVNVLK SVVSKHIETH SKLKLSNVTE KDAGKYWCRA SNFVGKSENA
     FWLNIYKPAV SPQKEDYYAD ILIYVTGCVL FILAVVIAIL CRMRMTTQKT LPTPPVQKLS
     KFPLKRQVSL DSNSSMNSNT PLVRIARLSS SDGPMLANVS ELELPSDPKW EFPRTRLTLG
     KPLGEGCFGQ VVMAEAVGID KEKPNKSLTV AVKMLKDDAT DKDLSDLVSE MEMMKMIGKH
     KNIINLLGAC TQDGPLYVLV EYASKGNLRE YLRARRPPGM DYSFDTCKIP DEQLTFKDLV
     SCAYQVARGM EYLASQKCIH RDLAARNVLV TEDNVMKIAD FGLARDVHNI DYYKKTTNGR
     LPVKWMAPEA LFDRVYTHQS DVWSYGVLLW EIFTLGGSPY PGIPVEELFK LLKEGHRMDK
     PANCTHELYM IMRECWHAVP SQRPTFRQLV EDHDRILSMT STDEYLDLSV PFEQYSPTCQ
     DSNSTCSSGD DSVFAHDPLP DEPCLPKQLP SNGVIRT
//