ID A0A3P9B138_9CICH Unreviewed; 817 AA. AC A0A3P9B138; DT 13-FEB-2019, integrated into UniProtKB/TrEMBL. DT 13-FEB-2019, sequence version 1. DT 05-JUN-2019, entry version 4. DE RecName: Full=Fibroblast growth factor receptor {ECO:0000256|PIRNR:PIRNR000628}; DE EC=2.7.10.1 {ECO:0000256|PIRNR:PIRNR000628}; OS Maylandia zebra (zebra mbuna). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids; OC Pseudocrenilabrinae; Haplochromini; Maylandia; OC Maylandia zebra complex. OX NCBI_TaxID=106582 {ECO:0000313|Ensembl:ENSMZEP00005003660, ECO:0000313|Proteomes:UP000265160}; RN [1] {ECO:0000313|Ensembl:ENSMZEP00005003660, ECO:0000313|Proteomes:UP000265160} RP NUCLEOTIDE SEQUENCE. RX PubMed=25186727; DOI=10.1038/nature13726; RA Brawand D., Wagner C.E., Li Y.I., Malinsky M., Keller I., Fan S., RA Simakov O., Ng A.Y., Lim Z.W., Bezault E., Turner-Maier J., RA Johnson J., Alcazar R., Noh H.J., Russell P., Aken B., Alfoldi J., RA Amemiya C., Azzouzi N., Baroiller J.F., Barloy-Hubler F., Berlin A., RA Bloomquist R., Carleton K.L., Conte M.A., D'Cotta H., Eshel O., RA Gaffney L., Galibert F., Gante H.F., Gnerre S., Greuter L., Guyon R., RA Haddad N.S., Haerty W., Harris R.M., Hofmann H.A., Hourlier T., RA Hulata G., Jaffe D.B., Lara M., Lee A.P., MacCallum I., Mwaiko S., RA Nikaido M., Nishihara H., Ozouf-Costaz C., Penman D.J., Przybylski D., RA Rakotomanga M., Renn S.C.P., Ribeiro F.J., Ron M., Salzburger W., RA Sanchez-Pulido L., Santos M.E., Searle S., Sharpe T., Swofford R., RA Tan F.J., Williams L., Young S., Yin S., Okada N., Kocher T.D., RA Miska E.A., Lander E.S., Venkatesh B., Fernald R.D., Meyer A., RA Ponting C.P., Streelman J.T., Lindblad-Toh K., Seehausen O., RA Di Palma F.; RT "The genomic substrate for adaptive radiation in African cichlid RT fish."; RL Nature 513:375-381(2014). RN [2] {ECO:0000313|Ensembl:ENSMZEP00005003660} RP IDENTIFICATION. RG Ensembl; RL Submitted (DEC-2018) to UniProtKB. CC -!- CATALYTIC ACTIVITY: CC Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L- CC tyrosyl-[protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, CC Rhea:RHEA-COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, CC ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; CC EC=2.7.10.1; Evidence={ECO:0000256|PIRNR:PIRNR000628, CC ECO:0000256|SAAS:SAAS01168082}; CC -!- SIMILARITY: Belongs to the protein kinase superfamily. Tyr protein CC kinase family. Fibroblast growth factor receptor subfamily. CC {ECO:0000256|PIRNR:PIRNR000628}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR Ensembl; ENSMZET00005003813; ENSMZEP00005003660; ENSMZEG00005002787. DR GeneTree; ENSGT00940000159880; -. DR Proteomes; UP000265160; LG19. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW. DR GO; GO:0004714; F:transmembrane receptor protein tyrosine kinase activity; IEA:UniProtKB-EC. DR Gene3D; 2.60.40.10; -; 3. DR InterPro; IPR016248; FGF_rcpt_fam. DR InterPro; IPR041159; FGFR_TM. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR013098; Ig_I-set. DR InterPro; IPR003599; Ig_sub. DR InterPro; IPR003598; Ig_sub2. DR InterPro; IPR011009; Kinase-like_dom_sf. DR InterPro; IPR000719; Prot_kinase_dom. DR InterPro; IPR017441; Protein_kinase_ATP_BS. DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom. DR InterPro; IPR008266; Tyr_kinase_AS. DR InterPro; IPR020635; Tyr_kinase_cat_dom. DR Pfam; PF18123; FGFR3_TM; 1. DR Pfam; PF07679; I-set; 1. DR Pfam; PF07714; Pkinase_Tyr; 1. DR PIRSF; PIRSF000628; FGFR; 1. DR PRINTS; PR00109; TYRKINASE. DR SMART; SM00409; IG; 3. DR SMART; SM00408; IGc2; 3. DR SMART; SM00219; TyrKc; 1. DR SUPFAM; SSF48726; SSF48726; 3. DR SUPFAM; SSF56112; SSF56112; 1. DR PROSITE; PS50835; IG_LIKE; 3. DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1. DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1. DR PROSITE; PS00109; PROTEIN_KINASE_TYR; 1. PE 3: Inferred from homology; KW ATP-binding {ECO:0000256|PIRNR:PIRNR000628, KW ECO:0000256|SAAS:SAAS00600564}; KW Complete proteome {ECO:0000313|Proteomes:UP000265160}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00916669}; KW Immunoglobulin domain {ECO:0000256|SAAS:SAAS00941986}; KW Kinase {ECO:0000256|PIRNR:PIRNR000628, ECO:0000256|SAAS:SAAS00601152}; KW Membrane {ECO:0000256|PIRNR:PIRNR000628, KW ECO:0000256|SAAS:SAAS00602125, ECO:0000256|SAM:Phobius}; KW Nucleotide-binding {ECO:0000256|PIRNR:PIRNR000628, KW ECO:0000256|SAAS:SAAS00600689}; KW Receptor {ECO:0000256|PIRNR:PIRNR000628, KW ECO:0000256|SAAS:SAAS00600436}; KW Repeat {ECO:0000256|SAAS:SAAS00295312}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transferase {ECO:0000256|PIRNR:PIRNR000628, KW ECO:0000256|SAAS:SAAS00601608}; KW Transmembrane {ECO:0000256|SAAS:SAAS00600943, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00602683, KW ECO:0000256|SAM:Phobius}; KW Tyrosine-protein kinase {ECO:0000256|PIRNR:PIRNR000628, KW ECO:0000256|SAAS:SAAS00582553}. FT SIGNAL 1 41 {ECO:0000256|SAM:SignalP}. FT CHAIN 42 817 Fibroblast growth factor receptor. FT {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5018227582. FT TRANSMEM 381 401 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 51 140 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 155 254 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 263 352 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 477 756 Protein kinase. {ECO:0000259|PROSITE: FT PS50011}. FT REGION 781 817 Disordered. {ECO:0000256|MobiDB-lite: FT A0A3P9B138}. FT ACT_SITE 622 622 Proton acceptor. {ECO:0000256|PIRSR: FT PIRSR000628-1}. SQ SEQUENCE 817 AA; 91504 MW; C5D97EDE06C62DB1 CRC64; MLSKLESGLA ALRLTSSPRG MTALWCSLWL SLLLPLTVVP AGLPTAQPTD PVSSETAFLE DYVLGIGDTL EMSCDPEEQE DHTEPIVWLK DGAGLVPCNR IRLGQRILRI INVSYDDSGV YSCHLARSNT LLSNYTIRVT DSLSSGDDED YDEDPEGAEA PYWTRPERMD KKLLAVPAAN TVKFRCAASG NPPPTIHWLK NGKEFKGEQR MGGIKLRHQQ WSLVMESAVP SDRGNYTCVV QNKYGSISHT YQLDVLERSP HRPILQAGLP ANQTVVVGSN VEFHCKVYSD AQPHIQWLKH IEVNGSRLGP DGVPYVNVLK SVVSKHIETH SKLKLSNVTE KDAGKYWCRA SNFVGKSENA FWLNIYKPAV SPQKEDYYAD ILIYVTGCVL FILAVVIAIL CRMRMTTQKT LPTPPVQKLS KFPLKRQVSL DSNSSMNSNT PLVRIARLSS SDGPMLANVS ELELPSDPKW EFPRTRLTLG KPLGEGCFGQ VVMAEAVGID KEKPNKSLTV AVKMLKDDAT DKDLSDLVSE MEMMKMIGKH KNIINLLGAC TQDGPLYVLV EYASKGNLRE YLRARRPPGM DYSFDTCKIP DEQLTFKDLV SCAYQVARGM EYLASQKCIH RDLAARNVLV TEDNVMKIAD FGLARDVHNI DYYKKTTNGR LPVKWMAPEA LFDRVYTHQS DVWSYGVLLW EIFTLGGSPY PGIPVEELFK LLKEGHRMDK PANCTHELYM IMRECWHAVP SQRPTFRQLV EDHDRILSMT STDEYLDLSV PFEQYSPTCQ DSNSTCSSGD DSVFAHDPLP DEPCLPKQLP SNGVIRT //