ID A0A3P8XWK5_ESOLU Unreviewed; 1344 AA. AC A0A3P8XWK5; DT 13-FEB-2019, integrated into UniProtKB/TrEMBL. DT 13-FEB-2019, sequence version 1. DT 07-OCT-2020, entry version 9. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSELUP00000008843}; OS Esox lucius (Northern pike). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Esociformes; OC Esocidae; Esox. OX NCBI_TaxID=8010 {ECO:0000313|Ensembl:ENSELUP00000008843}; RN [1] {ECO:0000313|Ensembl:ENSELUP00000008843} RP NUCLEOTIDE SEQUENCE. RX PubMed=25069045; RA Rondeau E.B., Minkley D.R., Leong J.S., Messmer A.M., Jantzen J.R., RA von Schalburg K.R., Lemon C., Bird N.H., Koop B.F.; RT "The genome and linkage map of the northern pike (Esox lucius): conserved RT synteny revealed between the salmonid sister group and the Neoteleostei."; RL PLoS ONE 9:e102089-e102089(2014). RN [2] {ECO:0000313|Ensembl:ENSELUP00000008843} RP IDENTIFICATION. RG Ensembl; RL Submitted (DEC-2018) to UniProtKB. CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein CC {ECO:0000256|ARBA:ARBA00004141}. CC -!- SIMILARITY: Belongs to the transient receptor (TC 1.A.4) family. LTrpC CC subfamily. TRPM2 sub-subfamily. {ECO:0000256|ARBA:ARBA00009501}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR Ensembl; ENSELUT00000004883; ENSELUP00000008843; ENSELUG00000009466. DR GeneTree; ENSGT00940000156404; -. DR OMA; EGYVDDC; -. DR Proteomes; UP000265140; LG20. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. DR GO; GO:0047631; F:ADP-ribose diphosphatase activity; IEA:InterPro. DR GO; GO:0005262; F:calcium channel activity; IEA:UniProtKB-KW. DR GO; GO:0019722; P:calcium-mediated signaling; IEA:GOC. DR GO; GO:0006979; P:response to oxidative stress; IEA:InterPro. DR InterPro; IPR005821; Ion_trans_dom. DR InterPro; IPR015797; NUDIX_hydrolase-like_dom_sf. DR InterPro; IPR029594; TRPM2. DR InterPro; IPR041491; TRPM_SLOG. DR PANTHER; PTHR13800:SF2; PTHR13800:SF2; 3. DR Pfam; PF00520; Ion_trans; 1. DR Pfam; PF18139; LSDAT_euk; 1. DR SUPFAM; SSF55811; SSF55811; 1. PE 3: Inferred from homology; KW Calcium {ECO:0000256|ARBA:ARBA00022837}; KW Calcium channel {ECO:0000256|ARBA:ARBA00022673}; KW Calcium transport {ECO:0000256|ARBA:ARBA00022568}; KW Cell membrane {ECO:0000256|ARBA:ARBA00022475}; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Ion channel {ECO:0000256|ARBA:ARBA00022673}; KW Ion transport {ECO:0000256|ARBA:ARBA00023065}; KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000265140}; KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}. FT TRANSMEM 666..684 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 717..737 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 786..805 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 811..833 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 853..873 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 940..965 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT DOMAIN 112..318 FT /note="LSDAT_euk" FT /evidence="ECO:0000259|Pfam:PF18139" FT DOMAIN 717..976 FT /note="Ion_trans" FT /evidence="ECO:0000259|Pfam:PF00520" FT COILED 571..591 FT /evidence="ECO:0000256|SAM:Coils" SQ SEQUENCE 1344 AA; 153397 MW; 77466A422AF2A9FF CRC64; MGESLLLEPS LAHSLAVSAA KTSKLSLCPS TQHYLASWIK DNIQKEECCF YVQGDREGVC MCGYLKIHHV DDSIKPESNQ AVTWDRHNHV RQVPTDAFGD ISFGGLGQKT GKYVRVSSDT KPEVLYQLLT EHWKLPPPNL IISVTGGAKN FYMKPQLKAQ FRRGLIKVAQ TTGAWIITGG THTGVMKHTG QAVRDYILSN NSTEGQIVTI GIATWGVIHN RKPLVHPQGR FPAYYSQDVQ TQGHMSCLDN NHSHFLLVDD GTNGRYGVEI ELRSRLERLI SQQPLGNKES GVRIPVVCVV LEGGPGTLNV LEHIYSTPFF QIQDMIQMSQ LLTVFRISED DHGDVDVAIL QALLKANRSS GSEGRESWER QLELAVAWNR VDIAKSDIFT EESQWKSSDL HEAMFSALLG NKHQFVRLFL ENGVCLRQFL QEDTTLCHLY THLPTSCFFL RLLVKRIQTE RTAAPLNISL RLVSDEIRHL LGSFTQPLYP LPGLAISYLK EDVSLQSKVP LKQQFSSVPG LGPDRGGASH RDPVRDLFLW AILQNKKELA EIAWEQCLDC MSAALAASKI LKKLAEEDEE EDDEAKEMRE LANYYERHAI GVFSECHSCD EDRARRMLIR SSPSWGHTTC LRLALEANDK SFIAHSGVQT LLTQIWCGEL AVDNPLWRVL LCMVFFPLTY IGFLRYSDPL TRTPPGLKPL NCSMRLVSLF TSPQVKFYWN IVFYFGFLLL FSVVLMIDFQ TTPSWRECLL YVWIFSLVCE EIRQLFHDPD GFPFNKKAKM YIKDMWNILD VLSILLFIIG LVFRLTTSLF YAGKVILCID FIIFCLRLMA IFIVSKTLGP KIIIVKRMIL DMFFFLFLLS IWVLAFGVAK QGILINNEDR LNWIVRGAVY EPYLIIFGNM PSDIDTTQFD ISACTVNGTD PLKPKCPVLN EDQRPAFPEW LTIILLCVYL LFANILLLNL LIAIFNYTFQ EVQDNTDNIW KFQRYELSPS HLFHLPLAPL PPPPGTSSTS PWHLFHLPLV HFFSEELSKE EEEELLSWES FMKDNYLQST RQQHSQDMDQ RQELTHPGHA LRFSVQVSQS AEALQWIMDA LKSQGFNAII DAPQLASPGK HCKDESADPK TKEVEKKSYH VNARRLVYPG SNITRFPVPE EKVPWEVEFS LYSPPVLNED GQVQSDRNPQ GRTGMRGRGS LCCLGPNHIL ELVLTRWRDT DGSVLEFLSV WNREESLWEL PGGLVQSDEP LSDRLQSIFG QRIYNRIKQL YVLQVYEGYV DDIRNTDSAW LETTVLNIHL DRTDHQLADI NRMTVSSLGC DEVVQWLEVN TSTRMSSYQK DSLRRVAELH LWNM //